Výsledky vyhledávání - "H I, Mosberg"

Structure-based design, synthesis, and pharmacologic evaluation of peptide RGS4 inhibitors

Autor: Y, Jin, H, Zhong, J R, Omnaas, R R, Neubig, H I, Mosberg

Publikováno v: The journal of peptide research : official journal of the American Peptide Society. 63(2)

Regulators of G-protein signaling (RGS) proteins form a multifunctional signaling family. A key role of RGS proteins is binding to the G-protein Galpha-subunit and acting as GTPase-activating proteins (GAPs), thereby rapidly terminating G protein-cou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::61d10f1ba5d583022acf391f763a1ec9
https://pubmed.ncbi.nlm.nih.gov/15009535

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Complementarity of delta opioid ligand pharmacophore and receptor models

Autor: H I, Mosberg

Publikováno v: Biopolymers. 51(6)

The elaboration of a pharmacophore model for the delta opioid receptor selective ligand JOM-13 (Tyr-c[D-Cys-Phe-D-Pen]OH) and the parallel, independent development of a structural model of the delta receptor are summarized. Although the backbone conf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::08ec98d730dc3feee285cff48a161bfb
https://pubmed.ncbi.nlm.nih.gov/10797231

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Modifications of the cyclic mu receptor selective tetrapeptide Tyr-c[D-Cys-Phe-D-Pen]NH2 (Et): effects on opioid receptor binding and activation

Autor: I J, McFadyen, J C, Ho, H I, Mosberg, J R, Traynor

Publikováno v: The journal of peptide research : official journal of the American Peptide Society. 55(3)

The previously described cyclic mu opioid receptor-selective tetrapeptide Tyr-c[D-Cys-Phe-D-Pen]NH2 (Et) (JOM-6) was modified at residues 1 and 3 by substitution with various natural and synthetic amino acids, and/or by alteration of the cyclic syste

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::aa09ba262ea7f3e34ff90955dca50ee7
https://pubmed.ncbi.nlm.nih.gov/10727108

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Prediction of protein structure: the problem of fold multiplicity

Autor: A L, Lomize, I D, Pogozheva, H I, Mosberg

Publikováno v: Proteins.

Three-dimensional (3D) models of four CASP3 targets were calculated using a simple modeling procedure that includes prediction of regular secondary structure, analysis of possible beta-sheet topologies, assembly of amphiphilic helices and beta-sheets

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7036356e43e6a9beb03f86168038a588
https://pubmed.ncbi.nlm.nih.gov/10526369

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Structural organization of G-protein-coupled receptors

Autor: A L, Lomize, I D, Pogozheva, H I, Mosberg

Publikováno v: Journal of computer-aided molecular design. 13(4)

Atomic-resolution structures of the transmembrane 7-alpha-helical domains of 26 G-protein-coupled receptors (GPCRs) (including opsins, cationic amine, melatonin, purine, chemokine, opioid, and glycoprotein hormone receptors and two related proteins,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a56253bddd68b3c32ad362b8607d1105
https://pubmed.ncbi.nlm.nih.gov/10425600

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Discriminative stimulus effects of a centrally administered, delta-opioid peptide (D-Pen2-D-Pen5-enkephalin) in pigeons

Autor: D C, Jewett, H I, Mosberg, J H, Woods

Publikováno v: Psychopharmacology. 127(3)

The present study assessed the discriminative stimulus effects of the delta-opioid agonist [D-Pen2-D-Pen5]enkephalin (DPDPE) in pigeons. Food-restricted pigeons were trained to discriminate between i.c.v injections of 100 micrograms [D-Pen2-D-Pen5]en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::268b5f6c373e6ed39f85a07a2aa559fc
https://pubmed.ncbi.nlm.nih.gov/8912400

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Development of a model for the delta-opioid receptor pharmacophore. 4. Residue 3 dehydrophenylalanine analogues of Tyr-c[D-Cys-Phe-D-Pen]OH (JOM-13) confirm required gauche orientation of aromatic side chain

Autor: H I, Mosberg, R K, Dua, I D, Pogozheva, A L, Lomize

Publikováno v: Biopolymers. 39(3)

We have previously proposed a model for the delta-opioid receptor binding conformation of the high affinity tetrapeptide Tyr-c[D-Cys-Phe-D-Pen]OH (JOM-13) based on experimental and theoretical conformational analysis of this peptide and a correlation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cd6c9bb8163ed6a1878a789dc6813296
https://pubmed.ncbi.nlm.nih.gov/8756510

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Development of a model for the delta-opioid receptor pharmacophore: 3. Comparison of the cyclic tetrapeptide, Tyr-c[D-Cys-Phe-D-Pen]OH with other conformationally constrained delta-receptor selective ligands

Autor: A L, Lomize, I D, Pogozheva, H I, Mosberg

Publikováno v: Biopolymers. 38(2)

We have previously proposed a model of the delta-opioid receptor bound conformation for the cyclic tetrapeptide, Tyr-c[D-Cys-Phe-D-Pen]OH (JOM-13) based on its conformational analysis and from conformation-affinity relationships observed for its anal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fd2b7c76b54a2ad941893abf93b212d3
https://pubmed.ncbi.nlm.nih.gov/8589255

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