Zobrazeno 1 - 10
of 38
pro vyhledávání: '"H H, Szeto"'
Publikováno v:
Clinical Pharmacology & Therapeutics. 96:629-633
Mitochondrial medicine is an evolving discipline whose importance derives from the central function of mitochondria in adenosine triphosphate (ATP) production, generation of reactive oxygen species, and cell death by necrosis or apoptosis. Consequent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::828f56afcabe9dd2a53896e3901fc86d
https://doi.org/10.1038/clpt.2014.177
https://doi.org/10.1038/clpt.2014.177
Autor:
Alex V. Birk, H H Szeto
Publikováno v:
Clinical Pharmacology & Therapeutics. 96:672-683
The mitochondrial electron transport chain (ETC) plays a central role in energy generation in the cell. Mitochondrial dysfunctions diminish adenosine triphosphate (ATP) production and result in insufficient energy to maintain cell function. As energy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ff48c7aa5353cc6527815c5dd975fe1
https://doi.org/10.1038/clpt.2014.174
https://doi.org/10.1038/clpt.2014.174
Publikováno v:
British journal of pharmacology. 171(8)
Cardiolipin plays an important role in mitochondrial respiration and cardiolipin peroxidation is associated with age-related diseases. Hydrophobic interactions between cytochrome c and cardiolipin converts cytochrome c from an electron carrier to a p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3f54e6307326cf4359e1406b8b91cbd6
https://pubmed.ncbi.nlm.nih.gov/24134698
https://pubmed.ncbi.nlm.nih.gov/24134698
Publikováno v:
Klinische Neurophysiologie. 35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76a1ae2a1d6030f44e3a07ca6796426f
https://doi.org/10.1055/s-2004-832171
https://doi.org/10.1055/s-2004-832171
Publikováno v:
Proceedings of the 20th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Vol.20 Biomedical Engineering Towards the Year 2000 and Beyond (Cat. No.98CH36286).
The fetal sheep brain develops cyclic electrocortical activity from approximately 0.8 gestation alternating between NREM and REM sleep. The aim of this study was to investigate developmental changes of the electrocorticogram (ECoG) after the occurren
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd2d4a02c67eba2895e0f883f3509a74
https://doi.org/10.1109/iembs.1998.747005
https://doi.org/10.1109/iembs.1998.747005
Autor:
H H, Szeto, J L, Lovelace, G, Fridland, Y, Soong, J, Fasolo, D, Wu, D M, Desiderio, P W, Schiller
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 298(1)
Recent evidence suggests that highly selective mu-opioid agonists may provide good analgesia with less development of tolerance and dependence. H-Tyr-D-Arg-Phe-Lys-NH2 (DALDA) and H-Dmt-D-Arg-Phe-Lys-NH2 ([Dmt1]DALDA) were found to display high bindi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b4a2b42f589d4415442876230f9ab35e
https://pubmed.ncbi.nlm.nih.gov/11408525
https://pubmed.ncbi.nlm.nih.gov/11408525
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 297(1)
DALDA (H-Tyr-D-Arg-Phe-Lys-NH(2)) and [Dmt(1)]DALDA (H-Dmt-D-Arg-Phe-Lys-NH(2)) (Dmt = 2',6'-dimethyltyrosine) are potent and highly selective mu-opioid agonists (K(i)(delta)/K(i)(mu)10,000 and K(i)(kappa)/K(i)(mu)100). Both peptides carry a 3+ charg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a193959907d4922dd317c16441463d10
https://pubmed.ncbi.nlm.nih.gov/11259564
https://pubmed.ncbi.nlm.nih.gov/11259564
Autor:
H H, Szeto, J F, Clapp, D M, Desiderio, P W, Schiller, O O, Grigoriants, Y, Soong, D, Wu, N, Olariu, J L, Tseng, R, Becklin
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 284(1)
Although synthetic opioid peptide analogs have been used extensively to study the functional roles of opioid receptors, little is known about their in vivo disposition. Our goal was to develop novel opioid drugs with limited transfer across the place
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8ab15de4075d93f12f4fcae84f4db623
https://pubmed.ncbi.nlm.nih.gov/9435161
https://pubmed.ncbi.nlm.nih.gov/9435161
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 281(1)
The role of receptor subtypes in opioid modulation of the hypothalamic-pituitary-adrenal (HPA) axis is well understood in the adult but has not been investigated in the developing fetus. Because the fetal HPA axis plays an important role in the devel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1f1423d9a599bc5941fcd4a3725ba839
https://pubmed.ncbi.nlm.nih.gov/9103489
https://pubmed.ncbi.nlm.nih.gov/9103489
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 280(1)
We previously reported that U50488H, a kappa-selective opioid agonist, stimulates the release of adrenocorticotropin (ACTH) in the ovine fetus via the release of hypothalamic arginine vasopressin and corticotropin releasing factor. In this study we e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b200f79972c268b7458f2e91fd3414c9
https://pubmed.ncbi.nlm.nih.gov/8996223
https://pubmed.ncbi.nlm.nih.gov/8996223