Výsledky vyhledávání

[From gene to disease; 'maturity-onset diabetes of the young' (MODY), monogenetic inheritable forms of diabetes mellitus]

Autor: J A, Maassen, H H, Lemkes, M, Losekoot

Publikováno v: Nederlands tijdschrift voor geneeskunde. 145(28)

Maturity-onset diabetes of the young (MODY) exhibits an autosomal dominant pattern of inheritance and can be divided in at least five subtypes (MODY 1 to 5), each subtype being caused by mutations in a specific gene. The unambiguous molecular diagnos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::92db5cbb84832072ad8e814b2d4a9cb7
https://pubmed.ncbi.nlm.nih.gov/11484433

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Elevated matrix metalloproteinase-2 and -9 in urine, but not in serum, are markers of type 1 diabetic nephropathy

Autor: M, Diamant, R, Hanemaaijer, J H, Verheijen, J W, Smit, J K, Radder, H H, Lemkes

Publikováno v: Diabetic medicine : a journal of the British Diabetic Association. 18(5)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a7164f452752f25c53ca1c902ca96630
https://pubmed.ncbi.nlm.nih.gov/11472458

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The DD genotype of the ACE gene polymorphism is associated with progression of diabetic nephropathy to end stage renal failure in IDDM

Autor: L J, Vleming, J W, van der Pijl, H H, Lemkes, R G, Westendorp, J A, Maassen, M R, Daha, L A, van Es, C, van Kooten

Publikováno v: Clinical nephrology. 51(3)

The insertion-deletion (I/D) polymorphism of the angiotensin converting enzyme gene is a diallelic polymorphism that constitutes a genetic influence on the progression of renal diseases such as IgA nephropathy. Patients with the DD genotype have an a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4d88fa53114a5b1187e20f80206aa60b
https://pubmed.ncbi.nlm.nih.gov/10099885

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Parental history of hypertension and parental history of diabetes and microvascular complications in insulin-dependent diabetes mellitus: the EURODIAB IDDM Complications Study

Autor: G, Roglic, H M, Colhoun, L K, Stevens, H H, Lemkes, C, Manes, J H, Fuller

Publikováno v: Diabetic medicine : a journal of the British Diabetic Association. 15(5)

Diabetic nephropathy clusters in families, suggesting an inherited predisposition. Parental history of hypertension and of Type 2 diabetes mellitus have been associated with nephropathy in offspring with Type 1 diabetes in some studies but not in oth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::57ad3e994b384538b632181ee0d06220
https://pubmed.ncbi.nlm.nih.gov/9737814

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Large electrodes improve nerve conduction repeatability in controls as well as in patients with diabetic neuropathy

Autor: A M, Tjon-A-Tsien, H H, Lemkes, A J, van der Kamp-Huyts, J G, van Dijk

Publikováno v: Musclenerve. 19(6)

Recording site is an important cause of variability of compound muscle action potential (CMAP) and conduction parameters, which can be reduced by using large electrodes. Repeatability of CMAP and conduction parameters of conventional and large electr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::eb3e8d6438f0c9d8fc818e522a06bd4b
https://pubmed.ncbi.nlm.nih.gov/8609917

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Effect of sulphated glycosaminoglycans on albuminuria in patients with overt diabetic (type 1) nephropathy

Autor: J T, Tamsma, F J, van der Woude, H H, Lemkes

Publikováno v: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 11(1)

Decreased expression of heparan sulphate has been shown in the glomerular basement membrane of patients with over diabetic nephropathy. Low- molecular-weight heparin (LMWH) is a highly sulphated glycosaminoglycan with strong structural and functional

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::90f9515de6d6483804bc343d79ed8cf7
https://pubmed.ncbi.nlm.nih.gov/9306374

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Heteroplasmy levels of a mitochondrial gene mutation associated with diabetes mellitus decrease in leucocyte DNA upon aging

Autor: L M, 't Hart, J J, Jansen, H H, Lemkes, P, de Knijff, J A, Maassen

Publikováno v: Human mutation. 7(3)

We showed previously that a mutation in the mitochondrial tRNALeu(UUR) gene at position 3243 associates with maternally inherited diabetes and deafness (MIDD). This mutation shows heteroplasmy in DNA from peripheral blood and other tissues. To examin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::95aaa93a20692ed1f2ab17574848e2a6
https://pubmed.ncbi.nlm.nih.gov/8829651

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