Zobrazeno 1 - 10 of 142 pro vyhledávání: '"H H, Bailey"'
2
Phase I clinical and pharmacokinetic study of perillyl alcohol administered four times a day
Autor: G H, Ripple, M N, Gould, R Z, Arzoomanian, D, Alberti, C, Feierabend, K, Simon, K, Binger, K D, Tutsch, M, Pomplun, A, Wahamaki, R, Marnocha, G, Wilding, H H, Bailey
Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 6(2)
We conducted a phase I dose-escalation trial of perillyl alcohol (POH; NSC 641066) given p.o. on a continuous four times a day basis to characterize the maximum tolerated dose, toxicities, pharmacokinetic profile, and antitumor activity. Sixteen eval
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3a1c0d6db0b48760ae5c7c71abf51478
https://pubmed.ncbi.nlm.nih.gov/10690515
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3
Paclitaxel, carboplatin, and hexamethyl-melamine (taxchex) as first-line therapy for ovarian cancer
Autor: E M, Hartenbach, L S, Harris, H H, Bailey, E A, Grosen, E, Larrison, D, Chen, L B, Twiggs, J C, Schink
Publikováno v: The cancer journal from Scientific American. 5(6)
The addition of hexamethylmelamine to therapy with cisplatin, cyclophosphamide, and doxorubicin significantly enhanced outcomes of patients with advanced ovarian cancer. Hexamethylmelamine, also known as altretamine, has potent antineoplastic activit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b2a9aab0900a2dce88bb52bb74abb549
https://pubmed.ncbi.nlm.nih.gov/10606473
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6
Transfection of complementary DNAs for the heavy and light subunits of human gamma-glutamylcysteine synthetase results in an elevation of intracellular glutathione and resistance to melphalan
Autor: R T, Mulcahy, H H, Bailey, J J, Gipp
Publikováno v: Cancer research. 55(21)
Although glutathione (GSH) has long been implicated in resistance to certain common chemotherapeutic agents, including alkylating agents, platinum analogues, and doxorubicin, evidence establishing a direct role in the resistant phenotype has been lac
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a16d1ece9152525a3b5edd3fb128e946
https://pubmed.ncbi.nlm.nih.gov/7585502
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8
Increase in gamma-glutamylcysteine synthetase activity and steady-state messenger RNA levels in melphalan-resistant DU-145 human prostate carcinoma cells expressing elevated glutathione levels
Autor: H H, Bailey, J J, Gipp, M, Ripple, G, Wilding, R T, Mulcahy
Publikováno v: Cancer research. 52(18)
The biochemical and molecular basis for the elevation of glutathione (GSH) levels commonly detected in many drug-resistant cells has not been elucidated. In a series of L-phenylalanine mustard-resistant human prostate carcinoma cell lines (DU-145), r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2d544b526bd9b8e06649b89e0f975cf3
https://pubmed.ncbi.nlm.nih.gov/1355406
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