Zobrazeno 1 - 10
of 524
pro vyhledávání: '"H Gümüş"'
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-12 (2023)
Abstract Recent studies show that rare, deleterious variants (RDVs) in certain genes are critical determinants of heritable cancer risk. To more comprehensively understand RDVs, we performed the largest-to-date germline variant calling analysis in a
Externí odkaz:
https://doaj.org/article/47e06faee0814247a1d715838f2deb86
Autor:
Yingjun Liu, Assunta Senatore, Silvia Sorce, Mario Nuvolone, Jingjing Guo, Zeynep H. Gümüş, Adriano Aguzzi
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-11 (2022)
Cultured brain slices from mice spontaneously upregulate senescence-associated genes over time and reproduce the transcriptional characteristics of aged brains; prions accelerate brain aging in brain slice cultures, animal models and human patients.
Externí odkaz:
https://doaj.org/article/cb415b47ad15403abc498a12c517ce80
Autor:
Berk Turhan, Zeynep H. Gümüş
Publikováno v:
Frontiers in Bioinformatics, Vol 2 (2022)
How we interact with computer graphics has not changed significantly from viewing 2D text and images on a flatscreen since their invention. Yet, recent advances in computing technology, internetworked devices and gaming are driving the design and dev
Externí odkaz:
https://doaj.org/article/3b0d871e79db44c29f8af8e17deb104e
Autor:
Ninad Oak, Andrew D. Cherniack, R. Jay Mashl, TCGA Analysis Network, Fred R. Hirsch, Li Ding, Rameen Beroukhim, Zeynep H. Gümüş, Sharon E. Plon, Kuan-lin Huang
Publikováno v:
Genome Medicine, Vol 12, Iss 1, Pp 1-15 (2020)
Abstract Background Distinct prevalence of inherited genetic predisposition may partially explain the difference of cancer risks across ancestries. Ancestry-specific analyses of germline genomes are required to inform cancer genetic risk and prognosi
Externí odkaz:
https://doaj.org/article/de60882de0a144c695b5152ddc10189b
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 1000-1011 (2020)
K-Ras is the most frequently mutated protein in human cancers. However, until very recently, its oncogenic mutants were viewed as undruggable. To develop inhibitors that directly target oncogenic K-Ras mutants, we need to understand both their mutant
Externí odkaz:
https://doaj.org/article/66dd03eefda54d57bfbe7b6d583d818a
Autor:
Yingjun Liu, Assunta Senatore, Silvia Sorce, Mario Nuvolone, Jingjing Guo, Zeynep H. Gümüş, Adriano Aguzzi
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/9311f4fd87ce44a1aaed5734925595f4
Publikováno v:
Journal of Applied Spectroscopy. 89:1150-1157
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a2244dab5f151ca04fb1944cde6748d
https://doi.org/10.1007/s10812-023-01481-2
https://doi.org/10.1007/s10812-023-01481-2
Autor:
Daniela Michlmayr, Eun-Young Kim, Adeeb H. Rahman, Rohit Raghunathan, Seunghee Kim-Schulze, Yan Che, Selim Kalayci, Zeynep H. Gümüş, Guillermina Kuan, Angel Balmaseda, Andrew Kasarskis, Steven M. Wolinsky, Mayte Suaréz-Fariñas, Eva Harris
Publikováno v:
Cell Reports, Vol 31, Iss 4, Pp - (2020)
Summary: Zika virus (ZIKV) is an emerging, mosquito-borne flavivirus responsible for recent epidemics across the Americas, and it is closely related to dengue virus (DENV). Here, we study samples from 46 DENV-naive and 43 DENV-immune patients with RT
Externí odkaz:
https://doaj.org/article/e1a425fa68a244c0842218a03703f886
Autor:
Irina S. Moreira, Panagiotis I. Koukos, Rita Melo, Jose G. Almeida, Antonio J. Preto, Joerg Schaarschmidt, Mikael Trellet, Zeynep H. Gümüş, Joaquim Costa, Alexandre M. J. J. Bonvin
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract We present SpotOn, a web server to identify and classify interfacial residues as Hot-Spots (HS) and Null-Spots (NS). SpotON implements a robust algorithm with a demonstrated accuracy of 0.95 and sensitivity of 0.98 on an independent test set
Externí odkaz:
https://doaj.org/article/bcfd8d40f8554bfebb790c4ceb05f28f
Autor:
Dajun Sang, Sudarshan Pinglay, Rafal P Wiewiora, Myvizhi E Selvan, Hua Jane Lou, John D Chodera, Benjamin E Turk, Zeynep H Gümüş, Liam J Holt
Publikováno v:
eLife, Vol 8 (2019)
Protein kinases are crucial to coordinate cellular decisions and therefore their activities are strictly regulated. Previously we used ancestral reconstruction to determine how CMGC group kinase specificity evolved (Howard et al., 2014). In the prese
Externí odkaz:
https://doaj.org/article/cf1238b4c14c4d008114e3f1e72dbd96