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Palmitoylation of the β4-Subunit Regulates Surface Expression of Large Conductance Calcium-activated Potassium Channel Splice Variants*

Autor: H.-G. Knaus, Lie Chen, Heather McClafferty, Michael J. Shipston, Lijun Tian, Peter Ruth, Franziska Steeb, Danlei Bi

Publikováno v: The Journal of Biological Chemistry
Chen, L, Bi, D, Tian, L, McClafferty, H, Steeb, F, Ruth, P, Knaus, H G & Shipston, M J 2013, ' Palmitoylation of the β4-Subunit Regulates Surface Expression of Large Conductance Calcium-activated Potassium Channel Splice Variants ', Journal of Biological Chemistry, vol. 288, no. 18, pp. 13136-13144 . https://doi.org/10.1074/jbc.M113.461830

Background: The role of post-translational modification of regulatory β-subunits in the control of large conductance potassium (BK) channels is largely unknown. Results: β4-subunit palmitoylation controls surface trafficking of BK channel α-subuni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f3e00ca86fb8c4e9ad3ed700c7ea401
http://europepmc.org/articles/PMC3642354

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Palmitoylation of the S0-S1 Linker Regulates Cell Surface Expression of Voltage- and Calcium-activated Potassium (BK) Channels

Autor: Iain Rowe, Heather McClafferty, Nina Geiger, H.-G. Knaus, Owen Jeffries, Lijun Tian, Peter Ruth, Danlei Bi, Michael J. Shipston, Lie Chen

Publikováno v: The Journal of Biological Chemistry
Jeffries, O, Geiger, N, Rowe, I C M, Tian, L J, McClafferty, H, Chen, L, Bi, D L, Knaus, H G, Ruth, P & Shipston, M J 2010, ' Palmitoylation of the S0-S1 Linker Regulates Cell Surface Expression of Voltage-and Calcium-activated Potassium (BK) Channels ', Journal of Biological Chemistry, vol. 285, no. 43, pp. 33307-33314 . https://doi.org/10.1074/jbc.M110.153940

S-Palmitoylation is rapidly emerging as an important post-translational mechanism to regulate ion channels. We have previously demonstrated that large conductance calcium-and voltage-activated potassium (BK) channels are palmitoylated within an alter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee08b4545c3db20696eef3bd87aa2629
https://doi.org/10.1074/jbc.m110.153940

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A Novel Isoform of SK2 Assembles with Other SK Subunits in Mouse Brain

Autor: Claudia A. Sailer, John P. Adelman, Timothy Strassmaier, Chris T. Bond, H.-G. Knaus, James Maylie

Publikováno v: Journal of Biological Chemistry. 280:21231-21236

The SK2 subtype of small conductance Ca2+-activated K+ channels is widely distributed throughout the central nervous system and modulates neuronal excitability by contributing to the afterhyperpolarization that follows an action potential. Western bl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::396e039de9e6e09ad53794296770fb06
https://doi.org/10.1074/jbc.m413125200

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Subcellular expression and neuroprotective effects of SK channels in human dopaminergic neurons

Autor: H-G. Knaus, Hans Zischka, Nikolaus Plesnila, Matthias Höllerhage, Carsten Culmsee, Günter U. Höglinger, A de Andrade, Lilja Meissner, Amalia M. Dolga, P Christophersen

Publikováno v: Cell Death & Disease
Cell death & disease 5(1), e999-e999 (2014). doi:10.1038/cddis.2013.530

Small-conductance Ca(2+)-activated K(+) channel activation is an emerging therapeutic approach for treatment of neurological diseases, including stroke, amyotrophic lateral sclerosis and schizophrenia. Our previous studies showed that activation of S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acf9e3f82cac3b3215981b433de92087
https://pubmed.ncbi.nlm.nih.gov/24434522

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High affinity interaction of mibefradil with voltage-gated calcium and sodium channels

Autor: P, Eller, S, Berjukov, S, Wanner, I, Huber, S, Hering, H G, Knaus, G, Toth, S D, Kimball, J, Striessnig

Publikováno v: British journal of pharmacology. 130(3)

Mibefradil is a novel Ca(2+) antagonist which blocks both high-voltage activated and low voltage-activated Ca(2+) channels. Although L-type Ca(2+) channel block was demonstrated in functional experiments its molecular interaction with the channel has

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::14c43f52b473e221a10203701fd96a4c
https://pubmed.ncbi.nlm.nih.gov/10821797

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Purification and functional reconstitution of high-conductance calcium-activated potassium channel from smooth muscle

Autor: M L, Garcia, K M, Giangiacomo, M, Hanner, H G, Knaus, O B, McManus, W A, Schmalhofer, G J, Kaczorowski

Publikováno v: Methods in enzymology. 294

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d83b8f4008573fffbe305f7b6c9ecfe3
https://pubmed.ncbi.nlm.nih.gov/9916233

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Scorpion toxins as tools for studying potassium channels

Autor: M L, Garcia, M, Hanner, H G, Knaus, R, Slaughter, G J, Kaczorowski

Publikováno v: Methods in enzymology. 294

The search for peptidyl inhibitors of K+ channels is a very active area of investigation. In addition to scorpion venoms, other venom sources have been investigated; all of these sources have yielded novel peptides with interesting properties. For in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::77dffd028976a0d25a2197ec9f0790a2
https://pubmed.ncbi.nlm.nih.gov/9916251

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