Zobrazeno 1 - 10
of 190
pro vyhledávání: '"H Frucht"'
Autor:
E B Goosenberg, James M. Gallo, P F Engstrom, Thomas C. Hamilton, Christine E. Szarka, T Halbherr, A M Balshem, G R Pfeiffer, F Green, Kang Shen Yao, M L Clapper, Peter J. O'Dwyer, H Frucht, Samuel Litwin, James M. Brennan
Publikováno v:
Journal of Clinical Investigation. 98:1210-1217
Prolonged exposure to mutagenic substances is strongly associated with an individual's risk of developing colorectal cancer. Clinical investigation of oltipraz as a chemopreventive agent is supported by its induction of the expression of detoxication
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::583b12884fe11ac78fbd57e6b2bbca8a
https://doi.org/10.1172/jci118904
https://doi.org/10.1172/jci118904
Autor:
N. Y. Jiang, Jacques-Pierre Moreau, Jia-Ming Qian, Sun Hyuk Kim, H. Frucht, David H. Coy, R. T. Jensen, Lu-Wa Wang, Jaw-Town Lin
Publikováno v:
Journal of Biological Chemistry. 266:16441-16447
During a search for possible cyclization points in shortened, potent bombesin agonists and antagonists, it was found that the joining of amino acid residues in positions 6 and 14 by various means resulted in retention of significant binding affinity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c318deb23865f05015b33d0c50a4b8d3
https://doi.org/10.1016/s0021-9258(18)55319-9
https://doi.org/10.1016/s0021-9258(18)55319-9
Publikováno v:
Journal of Clinical Investigation. 86:1904-1912
Cholera toxin (CT) inhibited the in vitro growth of three of four human small-cell lung carcinoma (SCLC) cell lines with a 50% inhibitory concentration of 27-242 ng/ml. Loss of surface membrane ruffling and the capacity of [Tyr4]-bombesin, vasopressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03703fbe1f3037f799cac763a539068f
https://doi.org/10.1172/jci114923
https://doi.org/10.1172/jci114923
Autor:
C E, Szarka, K S, Yao, G R, Pfeiffer, A M, Balshem, S, Litwin, H, Frucht, E B, Goosenberg, P F, Engstrom, M L, Clapper, P J, O'Dwyer
Publikováno v:
Cancer detection and prevention. 25(4)
The dithiolethione oltipraz is being developed as a chemopreventive agent for many malignancies, including colorectal cancer, on the basis of its in vivo protective activity against chemically induced tumors in a variety of animal models. This protec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::402e93dc2bb253cdb8c6c4822212d3c6
https://pubmed.ncbi.nlm.nih.gov/11531012
https://pubmed.ncbi.nlm.nih.gov/11531012
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 5(9)
We have demonstrated previously cell surface receptors for gastrointestinal peptides on 10 human colon cancer cell lines. Because most of the cells studied bind muscarinic cholinergic agonists, we undertook the determination of the cholinergic recept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::324e76a19b9e4a93c29551485c10252a
https://pubmed.ncbi.nlm.nih.gov/10499630
https://pubmed.ncbi.nlm.nih.gov/10499630
Autor:
M L, Clapper, C E, Szarka, G R, Pfeiffer, T A, Graham, A M, Balshem, S, Litwin, E B, Goosenberg, H, Frucht, P F, Engstrom
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 3(1)
Previous studies suggest that cruciferous vegetables may provide protection against carcinogen exposure by inducing detoxification enzymes. ICR(Ha) mice were gavaged with broccoli tablets (1 g/kg), and colon tissues were collected after treatment. Gl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::624ca65806ed45645e7fe933a1952b79
https://pubmed.ncbi.nlm.nih.gov/9815533
https://pubmed.ncbi.nlm.nih.gov/9815533
Autor:
C E, Szarka, G R, Pfeiffer, S T, Hum, L C, Everley, A M, Balshem, D F, Moore, S, Litwin, E B, Goosenberg, H, Frucht, P F, Engstrom
Publikováno v:
Cancer research. 55(13)
The glutathione S-transferases (alpha, mu, and pi), a family of Phase II detoxication enzymes, play a critical role in protecting the colon mucosa by catalyzing the conjugation of dietary carcinogens with glutathione. We investigated the efficacy of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::23dd4a56461d2d433cc50cc9c01f3216
https://pubmed.ncbi.nlm.nih.gov/7796404
https://pubmed.ncbi.nlm.nih.gov/7796404
Publikováno v:
Cancer research. 52(5)
Studies demonstrate that some colon cancers possess receptors for various gastrointestinal hormones or neurotransmitters, the occupation of which can affect growth. These results are limited because frequently only a small number of tumors are studie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::50423459ea02fc179e928cbd2fcc3bcf
https://pubmed.ncbi.nlm.nih.gov/1310640
https://pubmed.ncbi.nlm.nih.gov/1310640
Autor:
V. Shankaran, T. H. Luu, N. Nonzee, J. M. McKoy, J. G. Zivin, A. R. Ashford, R. Lantigua, H. Frucht, M. Scoppettone, C. L. Bennett, S. S. Gorin
Publikováno v:
Journal of Clinical Oncology. 27:6583-6583
6583 Background: Colorectal cancer (CRC) screening remains underutilized. Prior studies reported the cost-effectiveness of interventions to improve CRC screening, but none have been replicated in the setting of small medical practices. We recently co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::598d65979e078d092dc888ca1691a238
https://doi.org/10.1200/jco.2009.27.15_suppl.6583
https://doi.org/10.1200/jco.2009.27.15_suppl.6583