Zobrazeno 1 - 10
of 52
pro vyhledávání: '"H Fridborg"'
Publikováno v:
European Journal of Cancer. 35:424-432
The aim of this investigation was to evaluate the relationship between the disease-specific activity of cytotoxic drugs in the clinic and in fresh human tumour cells from patients, as detected by a non-clonogenic cytotoxicity assay. The activity of 1
Publikováno v:
British Journal of Cancer
The cytotoxic activity and cross-resistance pattern of the novel topoisomerase I inhibitor topotecan (Topo) were investigated in ten cell lines, representing different mechanisms of cytotoxic drug resistance, and in 218 fresh human tumour samples usi
Publikováno v:
Cancer. 79:1225-1233
Previous studies indicate that Cremophor EL (CEL), the excipient for Taxol, a clinical preparation of paclitaxel, has biologic properties per se.The cytotoxic activity of Taxol and its solvents CEL/ethanol, paclitaxel in ethanol, and 14 other cytotox
Autor:
P Nygren, K Csoka, B Jonsson, H Fridborg, J Bergh, H Hagberg, B Glimelius, O Brodin, B Tholander, A Kreuger, G Lönnerholm, A Jakobsson, L Olsen, J Kristensen, R Larsson
Publikováno v:
British Journal of Cancer
In patient tumour samples the activity in vitro of Taxol corresponded fairly well to the known clinical activity and Taxol showed low cross-resistance to standard cytotoxic drugs. However, the Taxol solvent Cremophor EL--ethanol was considerably acti
Autor:
H Fridborg, B Jonsson, P Nygren, K Csoka, K Nilsson, G Öberg, J Kristensen, J Bergh, B Tholander, L Olsen, Â Jakobson, R Larsson
Publikováno v:
British Journal of Cancer
The semiautomated fluorimetric microculture cytotoxicity assay (FMCA) was used for evaluation of the ability of cyclosporin A (CsA) and its novel non-immunosuppressive derivative SDZ PSC 833 (PSC) to modify the response to doxorubicin or vincristine
Autor:
Jörgen Kristensen, Rolf Larsson, Jan Liliemark, M. de la Torre, Peter Nygren, K Csoka, H Fridborg
Publikováno v:
European Journal of Cancer. 30:1022-1026
2-Chlorodeoxyadenosine (CdA) is a deaminase-resistant purine analogue which has shown clinical activity against various haematological tumours, and is currently undergoing phase II trials. In the present study, the semiautomated fluorometric microcul
Publikováno v:
International journal of oncology. 5(3)
Human adrenocortical tissue was immunohistochemically investigated with monoclonal antibodies C219 and JSB-1 for expression of P-glycoprotein (Pgp) associated with resistance to multiple cytotoxic drugs. All normal (n=7) and adenomatous (n=3) glands
Publikováno v:
British Journal of Cancer
The fluorometric microculture cytotoxicity assay (FMCA) was employed for analysing the effect of different chemotherapeutic drug combinations and their single constituents in 44 cases of acute myelocytic leukaemia (AML). A large heterogeneity with re
Publikováno v:
European journal of clinical pharmacology. 52(3)
The fluorometric microculture cytotoxic assay was employed for characterisation of the cytotoxic effect of cyclosporin A (CsA) and its non-immunosuppressive analogue SDZ PSC 833, [3-keto-Bmt1]-[Val2]-cyclosporin (PSC) in tumour cells from patients wi
Publikováno v:
Journal of experimental therapeuticsoncology. 1(5)
The feasibility of combined studies on a cell-line panel and primary cultures of patient tumor cells in the preclinical evaluation of new anticancer drugs was evaluated in a study of the activity and cross-resistance pattern in vitro of the new semi-