Zobrazeno 1 - 10
of 161
pro vyhledávání: '"H F Bunn"'
Cadmium and platinum suppression of erythropoietin production in cell culture: clinical implications
Publikováno v:
Blood. 96:3743-3747
Both toxic exposure to cadmium and cancer therapy with cisplatin (CDDP) can induce anemia in patients owing to the insufficient production of erythropoietin (EPO). Therefore, the effects of cadmium chloride (Cd) and CDDP in the Hep3B human hepatoma c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54afc5899f4b1d7c9484b2b54dd2c6e7
https://doi.org/10.1182/blood.v96.12.3743.h8003743_3743_3747
https://doi.org/10.1182/blood.v96.12.3743.h8003743_3743_3747
Autor:
H F Bunn, Benjamin L. Ebert
Publikováno v:
Molecular and Cellular Biology. 18:4089-4096
Molecular adaptation to hypoxia depends on the binding of hypoxia-inducible factor 1 (HIF-1) to cognate response elements in oxygen-regulated genes. In addition, adjacent sequences are required for hypoxia-inducible transcription. To investigate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b6eecff5053d36da4919688578414d7
https://doi.org/10.1128/mcb.18.7.4089
https://doi.org/10.1128/mcb.18.7.4089
Publikováno v:
Scopus-Elsevier
The physiological regulation of the red cell mass depends upon enhanced transcription of the erythropoietin (Epo) gene in response to hypoxia. Studies of Epo gene expression have been useful in investigating the mechanism by which cells and tissues s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b006f25bf0528da458fddddef0026c9f
https://doi.org/10.1242/jeb.201.8.1197
https://doi.org/10.1242/jeb.201.8.1197
Autor:
H. F. Bunn
During the past century, few proteins have matched erythropoietin (Epo) in capturing the imagination of physiologists, molecular biologists, and, more recently, physicians and patients. Its appeal rests on its commanding role as the premier erythroid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9cdb8d44d1a1791634344f5c8273222
https://europepmc.org/articles/PMC3579209/
https://europepmc.org/articles/PMC3579209/
Publikováno v:
The FASEB Journal. 9:1392-1395
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f7cd4fd6ec2c3d39778d49de2382241
https://doi.org/10.1096/fasebj.9.14.7589979
https://doi.org/10.1096/fasebj.9.14.7589979
Autor:
H F Bunn
Publikováno v:
Transfusion Clinique et Biologique. 2:433-439
A cell-free oxygen transporting blood substitute would obviate many of the current concerns about conventional red cell transfusion therapy. Moreover, a stable oxygen-carrying solution could have benefits and applications not possible with red cell t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f665466ceecd3ec6f964909f8f85e2e
https://doi.org/10.1016/s1246-7820(05)80068-0
https://doi.org/10.1016/s1246-7820(05)80068-0
Publikováno v:
Journal of Biological Chemistry. 269:22839-22846
In order to delineate functionally important domains in erythropoietin (Epo), we have prepared and tested a series of amino acid replacements at 51 conserved sites predicted to be on the surface of the molecule. Alanine replacements permitted preserv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9dca436283516456985facd566395de3
https://doi.org/10.1016/s0021-9258(17)31721-0
https://doi.org/10.1016/s0021-9258(17)31721-0
Autor:
J P Boissel, J. Czelusniak, T. E. Tracy, R. H. Gruninger, Danyi Wen, L. S. Mulcahy, H F Bunn, Michael J. Goodman
Publikováno v:
Blood. 82:1507-1516
To investigate structure-function relationships of erythropoietin (Epo), we have obtained cDNA sequences that encode the mature Epo protein of a variety of mammals. A first set of primers, corresponding to conserved nucleotide sequences between mouse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b1d57c7a6101b8d0a766b95f33a11e2
https://doi.org/10.1182/blood.v82.5.1507.1507
https://doi.org/10.1182/blood.v82.5.1507.1507