Zobrazeno 1 - 10
of 35
pro vyhledávání: '"H F Andersen"'
Publikováno v:
12517-12530
RSC Advances
RSC Advances
Electrodes containing 60 wt% micron-sized silicon were investigated with electrolytes containing carbonate solvents and either LiPF6 or lithium bis(fluorosulfonyl)imide (LiFSI) salt. The electrodes showed improved performance, with respect to capacit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::344b8179e499658d8b7fb0861a37c32e
https://hdl.handle.net/11250/3034319
https://hdl.handle.net/11250/3034319
Autor:
Martin R. Jakobsen, Martin K. Thomsen, Lars Østergaard, Rikke Olesen, Katharina Mack, Christian Krapp, Jesper F Højen, Martin Tolstrup, Frederik Dagnæs-Hansen, Paul W. Denton, Anna H. F. Andersen, Kasper L Jønsson
Publikováno v:
Andersen, A H F, Olesen, R, Jønsson, K L, Højen, J F, Krapp, C, Mack, K, Thomsen, M K, Østergaard, L, Tolstrup, M, Dagnæs-Hansen, F, Jakobsen, M R & Denton, P W 2019, ' cAIMP administration in humanized mice induces a chimerization-level-dependent STING response ', Immunology, vol. 157, no. 2, pp. 163-172 . https://doi.org/10.1111/imm.13061
Andersen, A H F, Olesen, R, Jønsson, K L, Højen, J F, Krapp, C, Mack, K, Thomsen, M K, Østergaard, L, Tolstrup, M, Dagnaes-Hansen, F, Jacobsen, M R & Denton, P W 2019, ' cAIMP administration in humanized mice induces a chimerization-level-dependent STING response ' Immunology . https://doi.org/10.1111/imm.13061
Immunology
Andersen, A H F, Olesen, R, Jønsson, K L, Højen, J F, Krapp, C, Mack, K, Thomsen, M K, Østergaard, L, Tolstrup, M, Dagnaes-Hansen, F, Jacobsen, M R & Denton, P W 2019, ' cAIMP administration in humanized mice induces a chimerization-level-dependent STING response ' Immunology . https://doi.org/10.1111/imm.13061
Immunology
It is well conceived that the STING signalling pathway is critical for generating a robust innate immune response to pathogens. Human and mouse STING signaling pathways are not identical, however. For example, mice lack IFI16 which has been proven im
Autor:
Martin Tolstrup, Stine Sofie Frank Nielsen, Ole Schmeltz Søgaard, Anna H. F. Andersen, Lars Østergaard, Paul W. Denton, Jakob Le Fèvre Harslund, Rikke Olesen
Publikováno v:
PLoS ONE
Andersen, A H F, Nielsen, S S F, Olesen, R, Harslund, J L F, Søgaard, O S, Østergaard, L, Denton, P W & Tolstrup, M 2020, ' Comparable human reconstitution following Cesium-137 versus X-ray irradiation preconditioning in immunodeficient NOG mice ', PLOS ONE, vol. 15, no. 10, e0241375 . https://doi.org/10.1371/journal.pone.0241375
PLoS ONE, Vol 15, Iss 10, p e0241375 (2020)
Andersen, A H F, Nielsen, S S F, Olesen, R, Harslund, J L F, Søgaard, O S, Østergaard, L, Denton, P W & Tolstrup, M 2020, ' Comparable human reconstitution following Cesium-137 versus X-ray irradiation preconditioning in immunodeficient NOG mice ', PLOS ONE, vol. 15, no. 10, e0241375 . https://doi.org/10.1371/journal.pone.0241375
PLoS ONE, Vol 15, Iss 10, p e0241375 (2020)
Humanized mouse models are used extensively in research involving human pathogens and diseases. However, most of these models require preconditioning. Radio-active sources have been used routinely for this purpose but safety issues have motivated res
Autor:
Martin Tolstrup, Anna H. F. Andersen
Publikováno v:
Viruses, Vol 12, Iss 412, p 412 (2020)
Halling Folkmar Andersen, A & Tolstrup, M 2020, ' The Potential of Long-Acting, Tissue-Targeted Synthetic Nanotherapy for Delivery of Antiviral Therapy Against HIV Infection ', Viruses, vol. 12, no. 4, 412 . https://doi.org/10.3390/v12040412
Viruses
Halling Folkmar Andersen, A & Tolstrup, M 2020, ' The Potential of Long-Acting, Tissue-Targeted Synthetic Nanotherapy for Delivery of Antiviral Therapy Against HIV Infection ', Viruses, vol. 12, no. 4, 412 . https://doi.org/10.3390/v12040412
Viruses
Oral administration of a combination of two or three antiretroviral drugs (cART) has transformed HIV from a life-threatening disease to a manageable infection. However, as the discontinuation of therapy leads to virus rebound in plasma within weeks,
Autor:
Paul W. Denton, Stine S F Nielsen, Frederik Dagnæs-Hansen, Rikke Olesen, Martin Tolstrup, Ole S. Søgaard, Katharina Mack, Niels Uldbjerg, Lars Østergaard, Anna H. F. Andersen
Publikováno v:
Andersen, A H F, Nielsen, S S F, Olesen, R, Mack, K, Dagnæs-Hansen, N F, Uldbjerg, N, Østergaard, L J, Søgaard, O S, Denton, P W & Tolstrup, M 2020, ' Humanized NOG Mice for Intravaginal HIV Exposure and Treatment of HIV Infection ', Journal of Visualized Experiments, vol. 2020, no. 155, e60723 . https://doi.org/10.3791/60723
Humanized mice provide a sophisticated platform to study human immunodeficiency virus (HIV) virology and to test antiviral drugs. This protocol describes the establishment of a human immune system in adult NOG mice. Here, we explain all the practical
Autor:
Martin Tolstrup, Frederik Dagnæs-Hansen, Anna H. F. Andersen, Alexander N. Zelikin, Paul W. Denton, Kaja Zuwala, Camilla Frich Riber
Publikováno v:
Andersen, A H F, Frich, C K, Zuwala, K, Tolstrup, M, Dagnæs-Hansen, F, Denton, P W & Zelikin, A N 2018, ' Long-Acting, Potent Delivery of Combination Antiretroviral Therapy ', ACS Macro Letters, vol. 7, no. 5, pp. 587–591 . https://doi.org/10.1021/acsmacrolett.8b00179
Antiretroviral therapy (ART) has revolutionized HIV treatment, yet grand challenges remain: (i) short blood and body residence time of the antiviral drugs, (ii) relative poor antiretroviral drug penetrance into key tissue reservoirs of viral infectio
Autor:
Lise L. Sørensen, Camilla Frich Riber, Alexander N. Zelikin, Paulina Gajda, Martin Tolstrup, Anna H. F. Andersen, Kaja Borup Løvschall, Kaja Zuwala
Publikováno v:
Journal of Controlled Release
Riber, C F, Zuwala, K, Løvschall, K, Andersen, A H F, Sørensen, L, Gajda, P, Tolstrup, M & Zelikin, A N 2018, ' Macromolecular prodrugs of ribavirin : Polymer backbone defines blood safety, drug release, and efficacy of anti-inflammatory effects ', Journal of Controlled Release, vol. 275, no. April, pp. 53-66 . https://doi.org/10.1016/j.jconrel.2018.02.012
Riber, C F, Zuwala, K, Løvschall, K, Andersen, A H F, Sørensen, L, Gajda, P, Tolstrup, M & Zelikin, A N 2018, ' Macromolecular prodrugs of ribavirin : Polymer backbone defines blood safety, drug release, and efficacy of anti-inflammatory effects ', Journal of Controlled Release, vol. 275, no. April, pp. 53-66 . https://doi.org/10.1016/j.jconrel.2018.02.012
Macromolecular (pro)drugs hold much promise as broad-spectrum antiviral agents as either microbicides or carriers for intracellular delivery of antiviral drugs. Intriguing opportunity exists in combining the two modes of antiviral activity in the sam
Autor:
Jan Münch, Frederik Dagnæs-Hansen, Raoul Walther, Cecilie Domar, Anna H. F. Andersen, Paul W. Denton, Martin Tolstrup, Alexander N. Zelikin, Franziska Krüger, Anne Tvilum, Camilla Kaas Frich, Søren R. Paludan
Publikováno v:
Frich, C K, Krüger, F, Walther, R, Domar, C, Andersen, A H F, Tvilum, A, Dagnæs-Hansen, F, Denton, P W, Tolstrup, M, Paludan, S R, Münch, JJ & Zelikin, A N 2019, ' Non-covalent hitchhiking on endogenous carriers as a protraction mechanism for antiviral macromolecular prodrugs ', Journal of Controlled Release, vol. 294, pp. 298-310 . https://doi.org/10.1016/j.jconrel.2018.12.016
Albumin is a highly successful tool of drug delivery providing drastically extended body and blood residence time for the associated cargo, but it only traffics single drug copies at a time. In turn, macromolecular prodrugs (MP) are advantaged in car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13e0f885ad2a9b45030651b6a787eada
https://pure.au.dk/portal/da/publications/noncovalent-hitchhiking-on-endogenous-carriers-as-a-protraction-mechanism-for-antiviral-macromolecular-prodrugs(50d7e7f5-a0ad-4a19-9f82-22c015626a7d).html
https://pure.au.dk/portal/da/publications/noncovalent-hitchhiking-on-endogenous-carriers-as-a-protraction-mechanism-for-antiviral-macromolecular-prodrugs(50d7e7f5-a0ad-4a19-9f82-22c015626a7d).html
Autor:
Florian Kreppel, Franziska Schandock, Janis A. Müller, Paulina Gajda, Kaja Zuwala, Jan Münch, Kaja Borup Løvschall, Anna H. F. Andersen, Mirja Harms, Martin Tolstrup, Camilla Frich Riber, Annika Röcker, Alexander N. Zelikin
Publikováno v:
Schandock, F, Riber, C F, Röcker, A, Müller, J A, Harms, M, Gajda, P, Zuwala, K, Andersen, A H F, Løvschall, K B, Tolstrup, M, Kreppel, F, Münch, J & Zelikin, A N 2017, ' Macromolecular Antiviral Agents against Zika, Ebola, SARS, and Other Pathogenic Viruses ', Advanced Healthcare Materials . https://doi.org/10.1002/adhm.201700748
Advanced Healthcare Materials
Advanced Healthcare Materials
Viral pathogens continue to constitute a heavy burden on healthcare and socioeconomic systems. Efforts to create antiviral drugs repeatedly lag behind the advent of pathogens and growing understanding is that broad‐spectrum antiviral agents will ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::053bee39f9568aa99758d859db2c32c1
https://pure.au.dk/portal/da/publications/macromolecular-antiviral-agents-against-zika-ebola-sars-and-other-pathogenic-viruses(6beaa39b-4eb1-4b35-8c97-7fa4549e97a6).html
https://pure.au.dk/portal/da/publications/macromolecular-antiviral-agents-against-zika-ebola-sars-and-other-pathogenic-viruses(6beaa39b-4eb1-4b35-8c97-7fa4549e97a6).html
Autor:
Camilla Frich Riber, Alexander N. Zelikin, Thomas Pietschmann, Martin Tolstrup, Kaja Zuwala, Lærke Anegaard Rolskov, Anna H. F. Andersen, Frederik Dagnæs-Hansen, Dominic H. Banda, Paulina Gajda, Kaja Borup Løvschall
Publikováno v:
Riber, C F, Halling Folkmar Andersen, A, Anegaard Rolskov, L, Zuwala, K, Gajda, P, Borup Løvschall, K, Dagnæs-Hansen, F, Banda, D H, Pietschmann, T, Tolstrup, M & Zelikin, A N 2017, ' Synthetic Polymer with a Structure-Driven Hepatic Deposition and Curative Pharmacological Activity in Hepatic Cells ', ACS Macro Letters, vol. 6, no. 935-940, pp. 935-940 . https://doi.org/10.1021/acsmacrolett.7b00471
Synthetic polymers make strong contributions as tools for delivery of biological drugs and chemotherapeutics. The most praised characteristic of polymers in these applications is complete lack of pharmacological function such as to minimize the side
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82c8191c1d250e7728b18664848f1c84
https://pure.au.dk/portal/da/publications/synthetic-polymer-with-a-structuredriven-hepatic-deposition-and-curative-pharmacological-activity-in-hepatic-cells(9134d4f3-5802-4c4e-b8ad-e593958be9de).html
https://pure.au.dk/portal/da/publications/synthetic-polymer-with-a-structuredriven-hepatic-deposition-and-curative-pharmacological-activity-in-hepatic-cells(9134d4f3-5802-4c4e-b8ad-e593958be9de).html