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Fast uplift in the southern Patagonian Andes due to long- and short-term deglaciation and the asthenospheric window underneath.

Autor: Muller, Veleda A. P.^1,2 (AUTHOR) veledamuller@arizona.edu, Sternai, Pietro² (AUTHOR), Sue, Christian^3,4 (AUTHOR)

Publikováno v: Solid Earth. 2024, Vol. 15 Issue 4, p387-404. 18p.

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2-(Aminomethyl)phenols, a new class of saluretic agents. 4. Effects of oxygen and/or nitrogen substitution

Autor: H. F. Russo, A. A. Deana, Smith Robert L, Cragoe Edward J, Gerald E. Stokker, Everett M. Schultz, L. S. Watson, S J deSolms, J. E. Baer

Publikováno v: Journal of Medicinal Chemistry. 25:735-742

A series of oxygen and/or nitrogen substituted 2-(aminomethyl)phenols was synthesized and tested orally in rats for saluretic and diuretic effects. Intravenous dog data are included as supplementary material to demonstrate diuretic responses, or lack

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::662dd11ab28bfde25e2857bd992846f0
https://doi.org/10.1021/jm00348a024

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2-(Aminomethyl)phenols, a new class of saluretic agents. 6. Effects of N,O-spiroannulation and subsequent quarternization

Autor: Cragoe Edward J, Gerald E. Stokker, Charles S. Sweet, H. F. Russo, L. S. Watson, Smith Robert L, Ludden Ct, Everett M. Schultz

Publikováno v: Journal of Medicinal Chemistry. 26:585-590

The synthesis of a number of 3,4-dihydrospiro-2H-1,3-benzoxazines and their corresponding benzoxazinium salts are reported. The saluretic effects displayed by these N,O-spiroannulated 2-(aminomethyl)phenols appear to be, in part, inversely related to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::135f17320f0e2a9b2c35b2e69b19b9bb
https://doi.org/10.1021/jm00358a024

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2-(Aminomethyl)phenols, a new class of saluretic agents. 5. Fused-ring analogs

Autor: L. S. Watson, A. A. Deana, H. F. Russo, Smith Robert L, Gerald E. Stokker, Cragoe Edward J, Everett M. Schultz

Publikováno v: Journal of Medicinal Chemistry. 26:580-585

A number of bicyclic ring-fused analogues of 2-(aminomethyl)phenol were synthesized and tested orally in rats and intravenously in dogs for saluretic and diuretic effects. Of the 15 alicylic, aromatic, and heterocyclic ring-fused compounds tested, on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce3c440c9041751946d4642c7c09a0e6
https://doi.org/10.1021/jm00358a023

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2-(Aminomethyl)phenols, a new class of saluretic agents. 2. Synthesis and pharmacological properties of the 5-aza isostere of 2-(aminomethyl)-4-(1,1-dimethylethyl)-6-iodophenol

Autor: H. F. Russo, Ludden Ct, L. S. Watson, Smith Robert L, Charles S. Sweet, Gerald E. Stokker, Cragoe Edward J

Publikováno v: Journal of Medicinal Chemistry. 24:115-117

The synthesis and biological evaluation of 4-(aminomethyl)-6-(1,1-dimethylethyl)-2-iodo-3-pyridinol dihydrochloride (7b) are described. Compound 7b proved to be highly active as a saluretic diuretic in both rats and dogs.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::118703a3faae6aff926ded5987df0d66
https://doi.org/10.1021/jm00133a024

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