Výsledky vyhledávání - "H F, Paterson"

A single autophosphorylation site confers oncogenicity to the Neu/ErbB-2 receptor and enables coupling to the MAP kinase pathway

Autor: Yosef Yarden, H. F. Paterson, C. J. Marshall, R. Ben-Levy

Publikováno v: The EMBO Journal. 13:3302-3311

The transforming potential of the Neu/ErbB-2 receptor tyrosine kinase undergoes inactivation by deletion of the non-catalytic C-terminal tail, which contains five autophosphorylation sites. To determine which site is essential for oncogenicity, we ta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72c3505215e7b68c537bd3844e9b65b5
https://doi.org/10.1002/j.1460-2075.1994.tb06632.x

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CTCF, a conserved nuclear factor required for optimal transcriptional activity of the chicken c-myc gene, is an 11-Zn-finger protein differentially expressed in multiple forms

Autor: Victor V. Lobanenkov, Graham H. Goodwin, H F Paterson, Robert H. Nicolas, Alexander F. Carne, Elena Klenova, C M Heath, Paul E. Neiman

Publikováno v: Molecular and Cellular Biology. 13:7612-7624

A novel sequence-specific DNA-binding protein, CTCF, which interacts with the chicken c-myc gene promoter, has been identified and partially characterized (V. V. Lobanenkov, R. H. Nicolas, V. V. Adler, H. Paterson, E. M. Klenova, A. V. Polotskaja, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2edcec2dab1a42b4b07a49c7eae909a8
https://doi.org/10.1128/mcb.13.12.7612

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Regulation of Ras.GTP loading and Ras-Raf association in neonatal rat ventricular myocytes by G protein-coupled receptor agonists and phorbol ester. Activation of the extracellular signal-regulated kinase cascade by phorbol ester is mediated by Ras

Autor: A, Chiloeches, H F, Paterson, R, Marais, A, Clerk, C J, Marshall, P H, Sugden

Publikováno v: The Journal of biological chemistry. 274(28)

The small G protein Ras has been implicated in hypertrophy of cardiac myocytes. We therefore examined the activation (GTP loading) of Ras by the following hypertrophic agonists: phorbol 12-myristate 13-acetate (PMA), endothelin-1 (ET-1), and phenylep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c78cb3dfeb438a729aee494952f117ef
https://pubmed.ncbi.nlm.nih.gov/10391918

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p21Ras activation by the guanine nucleotide exchange factor Sos, requires the Sos/Grb2 interaction and a second ligand-dependent signal involving the Sos N-terminus

Autor: J L, Byrne, H F, Paterson, C J, Marshall

Publikováno v: Oncogene. 13(10)

It has been suggested that a key event in growth factor-induced p21Ras activation by the guanine nucleotide exchange factor Sos, is the recruitment of Sos to the plasma membrane by its interaction with the adaptor protein Grb2. However, other evidenc

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https://pubmed.ncbi.nlm.nih.gov/8950972

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Reversion of a human tumour cell line containing oncogenic p21ras is associated with a defect in the post-translational processing of the ras protein

Autor: P A, Tilbrook, H F, Paterson, C J, Marshall

Publikováno v: Oncogene. 10(4)

Correct post-translational modifications of the ras proteins are essential for their membrane localisation and functioning. The flat revertant cell lines 1aCB and 8b, derived from the human bladder carcinoma cell line EJ, contain the transforming gen

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https://pubmed.ncbi.nlm.nih.gov/7862461

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Different structural organization of Ras and Rho effector domains

Autor: A J, Self, H F, Paterson, A, Hall

Publikováno v: Oncogene. 8(3)

Ras regulates proliferation and differentiation signals in cells, and activation of the protein can lead to malignant transformation. Activation of the related protein, Rho, affects cell morphology, and it has been suggested that it may also have som

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https://pubmed.ncbi.nlm.nih.gov/8437849

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Section 29

Autor: H. F. Paterson, A. R. Dabbs

Publikováno v: British Journal of Psychiatry. 109:202-205

The wording of the Mental Health Act, 1959 makes it clear that an application under Section 29 replaces both the old Urgency Order and the D.A.O.'s three-day order as a means of compulsory admission to a mental hospital or the psychiatric ward of a g

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https://doi.org/10.1192/bjp.109.459.202

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In vivo and in vitro studies on the early embryonic lethal oligosyndactylism (Os) in the mouse

Autor: H F, Paterson

Publikováno v: Journal of embryology and experimental morphology. 52

The development of mouse embryos homozygous for oligosyndactylism (Os) is arrested during implantation. Histological investigations confirm a previous report that cells become blocked in mitosis, and air-dried spreads of the mutant embryos reveal tha

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https://pubmed.ncbi.nlm.nih.gov/230280

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