Zobrazeno 1 - 9
of 9
pro vyhledávání: '"H F, Bigg"'
Autor:
S H Ridley, S J Sarsfield, J C Lee, H F Bigg, T E Cawston, D J Taylor, D L DeWitt, J Saklatvala
Publikováno v:
The Journal of Immunology. 158:3165-3173
The role of p38 mitogen-activated protein kinase (MAPK) in responses of human fibroblasts and vascular endothelial cells to IL-1 was investigated by use of a pyridinyl imidazole compound (SB 203580), which specifically inhibits the enzyme. SB 203580
Publikováno v:
Annals of the Rheumatic Diseases. 52:177-181
The metalloproteinases are a family of enzymes that can degrade all the components of the extracellular matrix. These potent enzymes are often found in proenzyme forms and require activation before the substrate can be digested. To prevent unlimited
Publikováno v:
Biochemical Journal. 285:143-147
Connective-tissue cells in culture produce a family of metalloproteinases which, once activated, can degrade all the components of the extracellular matrix. These potent enzymes are all inhibited by the tissue inhibitor of metalloproteinases (TIMP),
Autor:
C M, Overall, E, Tam, G A, McQuibban, C, Morrison, U M, Wallon, H F, Bigg, A E, King, C R, Roberts
Publikováno v:
The Journal of biological chemistry. 275(50)
On the cell surface, the 59-kDa membrane type 1-matrix metalloproteinase (MT1-MMP) activates the 72-kDa progelatinase A (MMP-2) after binding the tissue inhibitor of metalloproteinases (TIMP)-2. A 44-kDa remnant of MT1-MMP, with an N terminus at Gly(
Publikováno v:
European journal of biochemistry. 267(13)
The addition of all-trans retinoic acid (ATRA) in combination with basic fibroblast growth factor (bFGF) to human fibroblasts results in a synergistic induction of tissue inhibitor of metalloproteinases-1 (TIMP-1) protein production. The synergistic
Publikováno v:
The Journal of biological chemistry. 272(24)
The binding properties of the newly described tissue inhibitor of metalloproteinases-4 (TIMP-4) to progelatinase A and to the COOH-terminal hemopexin-like domain (C domain) of the enzyme were examined. We present evidence for the first time of a spec
Autor:
S H, Ridley, S J, Sarsfield, J C, Lee, H F, Bigg, T E, Cawston, D J, Taylor, D L, DeWitt, J, Saklatvala
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 158(7)
The role of p38 mitogen-activated protein kinase (MAPK) in responses of human fibroblasts and vascular endothelial cells to IL-1 was investigated by use of a pyridinyl imidazole compound (SB 203580), which specifically inhibits the enzyme. SB 203580
Autor:
H F, Bigg, T E, Cawston
Publikováno v:
Journal of cellular physiology. 166(1)
This report shows for the first time that platelet-derived growth factor-BB (PDGF-BB) and transforming growth factor-beta (TGF-beta) can interact in a synergistic manner with retinoic acid to stimulate the production of tissue inhibitor of metallopro
Publikováno v:
Bone. 15:126