Zobrazeno 1 - 10
of 421
pro vyhledávání: '"H Eric, Xu"'
Autor:
Yang Li, Qingning Yuan, Xinheng He, Yumu Zhang, Chongzhao You, Canrong Wu, Jingru Li, H. Eric Xu, Li-Hua Zhao
Publikováno v:
Cell Discovery, Vol 10, Iss 1, Pp 1-12 (2024)
Abstract Prolactin-releasing peptide (PrRP) is an RF-amide neuropeptide that binds and activates its cognate G protein-coupled receptor, prolactin-releasing peptide receptor (PrRPR), also known as GPR10. PrRP and PrRPR are highly conserved across mam
Externí odkaz:
https://doaj.org/article/ffea06cafb9843238d672de7aa5cd414
Autor:
Wenzhuo Li, Qingtong Zhou, Zhaotong Cong, Qingning Yuan, Wenxin Li, Fenghui Zhao, H. Eric Xu, Li-Hua Zhao, Dehua Yang, Ming-Wei Wang
Publikováno v:
Cell Discovery, Vol 10, Iss 1, Pp 1-4 (2024)
Externí odkaz:
https://doaj.org/article/a0a71dfb72d74b849e435f738a3848eb
Autor:
Sanshan Jin, Shimeng Guo, Youwei Xu, Xin Li, Canrong Wu, Xinheng He, Benxun Pan, Wenwen Xin, Heng Zhang, Wen Hu, Yuling Yin, Tianwei Zhang, Kai Wu, Qingning Yuan, H. Eric Xu, Xin Xie, Yi Jiang
Publikováno v:
Cell Discovery, Vol 10, Iss 1, Pp 1-13 (2024)
Abstract The neuropeptide 26RFa, a member of the RF-amide peptide family, activates the pyroglutamylated RF-amide peptide receptor (QRFPR), a class A GPCR. The 26RFa/QRFPR system plays critical roles in energy homeostasis, making QRFPR an attractive
Externí odkaz:
https://doaj.org/article/1dd02c6ef3f34c349ea569c47548e552
Autor:
Qian He, Qingning Yuan, Hong Shan, Canrong Wu, Yimin Gu, Kai Wu, Wen Hu, Yumu Zhang, Xinheng He, H. Eric Xu, Li-Hua Zhao
Publikováno v:
Cell Discovery, Vol 10, Iss 1, Pp 1-13 (2024)
Abstract Melanin-concentrating hormone (MCH) is a cyclic neuropeptide that regulates food intake, energy balance, and other physiological functions by stimulating MCHR1 and MCHR2 receptors, both of which are class A G protein-coupled receptors. MCHR1
Externí odkaz:
https://doaj.org/article/26f5adc57d7e4d8891df0876082f58fe
Autor:
Hongmin Cai, Shimeng Guo, Youwei Xu, Jun Sun, Junrui Li, Zhikan Xia, Yi Jiang, Xin Xie, H. Eric Xu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract The adenosine A3 receptor (A3AR), a key member of the G protein-coupled receptor family, is a promising therapeutic target for inflammatory and cancerous conditions. The selective A3AR agonists, CF101 and CF102, are clinically significant, y
Externí odkaz:
https://doaj.org/article/4814eb6bde874961bae82507728016df
Publikováno v:
Medicine in Drug Discovery, Vol 24, Iss , Pp 100201- (2024)
G protein-coupled receptors (GPCRs) constitute a diverse and extensive array of cell surface receptors, rendering them essential targets for drugs aimed at various human diseases. Responding to a range of extracellular or intracellular cues, GPCRs re
Externí odkaz:
https://doaj.org/article/49333e187e664c3988f37e2d26e15600
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114511- (2024)
Summary: Bombesin receptor subtype-3 (BRS3) is an important orphan G protein-coupled receptor that regulates energy homeostasis and insulin secretion. As a member of the bombesin receptor (BnR) family, the lack of known endogenous ligands and high-re
Externí odkaz:
https://doaj.org/article/854de4b8d8a54817b8b51437325d9661
Autor:
Shiyi Shen, Dongxue Wang, Heng Liu, Xinheng He, Yinglong Cao, Juanhua Chen, Shujie Li, Xi Cheng, H. Eric Xu, Jia Duan
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114389- (2024)
Summary: Kisspeptin signaling through its G protein-coupled receptor, KISS1R, plays an indispensable role in regulating reproduction via the hypothalamic-pituitary-gonadal axis. Dysregulation of this pathway underlies severe disorders like infertilit
Externí odkaz:
https://doaj.org/article/9c255df8d34046729b6af43aebba673c
Autor:
Lulu Guo, Yumu Zhang, Guoxing Fang, Lu Tie, Yuming Zhuang, Chenyang Xue, Qi Liu, Minghui Zhang, Kongkai Zhu, Chongzhao You, Peiyu Xu, Qingning Yuan, Chao Zhang, Lei Liu, Naikang Rong, Shengxuan Peng, Yuan Liu, Chuanzheng Wang, Xin Luo, Zongyao Lv, Dongwei Kang, Xiao Yu, Cheng Zhang, Yi Jiang, Xinzhong Dong, Jiuyao Zhou, Zhongmin Liu, Fan Yang, H. Eric Xu, Jin-Peng Sun
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract MRGPRX1, a Mas-related GPCR (MRGPR), is a key receptor for itch perception and targeting MRGPRX1 may have potential to treat both chronic itch and pain. Here we report cryo-EM structures of the MRGPRX1-Gi1 and MRGPRX1-Gq trimers in complex w
Externí odkaz:
https://doaj.org/article/760d907008f24e78b84b2534b10f2648
Autor:
Wenjing Sun, Fan Yang, Huanhuan Zhang, Qingning Yuan, Shenglong Ling, Yuanxia Wang, Pei Lv, Zelin Li, Yifan Luo, Dongsheng Liu, Wanchao Yin, Pan Shi, H. Eric Xu, Changlin Tian
Publikováno v:
Cell Discovery, Vol 9, Iss 1, Pp 1-12 (2023)
Abstract Neurokinin 3 receptor (NK3R) is a tachykinin receptor essential for the hypothalamic-pituitary-gonadal axis. The endogenous peptide agonist neurokinin B (NKB) preferentially activates NK3R, while substance P (SP) binds preferentially to NK1R
Externí odkaz:
https://doaj.org/article/86a6848830a84a3ea55f00850efe8f39