Zobrazeno 1 - 10
of 31
pro vyhledávání: '"H E Gendelman"'
Autor:
P H, Gordon, C, Doorish, J, Montes, R L, Mosley, R L, Mosely, B, Diamond, R B, Macarthur, L H, Weimer, P, Kaufmann, A P, Hays, L P, Rowland, H E, Gendelman, S, Przedborski, H, Mitsumoto
Publikováno v:
Neurology. 66:1117-1119
The authors conducted a randomized controlled trial to test the safety and immunology of glatiramer acetate in ALS. Twenty treated patients were randomly assigned to daily or biweekly injections. Ten control patients were selected from another trial
Autor:
S. Krajewski, H. J. James, J. Ross, B. M. Blumberg, L. G. Epstein, H. E. Gendelman, S. Gummuluru, S. Dewhurst, L. R. Sharer, J. C. Reed, H. A. Gelbard
Publikováno v:
Neuropathology and Applied Neurobiology. 23:242-253
Publikováno v:
The Journal of Immunology. 158:3499-3510
HIV-1 invades the central nervous system early during viral infection, but neurologic impairment usually occurs years later. The strongest predictor for clinical dementia is the absolute numbers of immunocompetent brain macrophages. Thus, how monocyt
Autor:
H S Nottet, Y Persidsky, V G Sasseville, A N Nukuna, P Bock, Q H Zhai, L R Sharer, R D McComb, S Swindells, C Soderland, H E Gendelman
Publikováno v:
The Journal of Immunology. 156:1284-1295
HIV-1 penetration of the brain is a pivotal event in the neuropathogenesis of AIDS-associated dementia. The establishment of productive viral replication or up-regulation of adhesion molecule expression on brain microvascular endothelial cells (BMVEC
Publikováno v:
The Journal of Immunology. 146:3396-3404
Several reports implicate Langerhans cells of skin as susceptible targets, reservoirs, and vectors for transmission of HIV: 1) numbers of Langerhans cells in skin of HIV-infected patients were decreased about 50% of that in control skin; 2) as many a
Autor:
D C Kalter, M Nakamura, J A Turpin, L M Baca, D L Hoover, C Dieffenbach, P Ralph, H E Gendelman, M S Meltzer
Publikováno v:
The Journal of Immunology. 146:298-306
Monocytes cultured 7 to 10 days in recombinant human macrophage CSF (MCSF) were greater than 400-fold more susceptible to HIV infection than an equal number of cells cultured in medium alone. Levels of reverse transcriptase activity and p24 Ag in cul
Autor:
H E Gendelman, L M Baca, J Turpin, D C Kalter, B Hansen, J M Orenstein, C W Dieffenbach, R M Friedman, M S Meltzer
Publikováno v:
The Journal of Immunology. 145:2669-2676
In a survey of 15 different virus isolates, no IFN-alpha or IFN-beta activity was detected in culture fluids of HIV-infected T cells or monocytes. Exogenous rIFN-alpha added to T lymphoblast or monocyte cultures induced restriction in replication of
Publikováno v:
Advances in experimental medicine and biology. 493
Memory deficits are common among drug abusers and in those with chronic neurodegenerative disorders. Currently, the mechanisms through which diverse neurophysiologic processes alter memory are not known. This review describes the current systems and
Publikováno v:
Journal of leukocyte biology. 68(3)
The neuropathogenesis of HIV-1 infection revolves around the production of secretory factors from immune-activated brain mononuclear phagocytes (MP). MP-secreted chemokines may play several roles in HIV-1 encephalitis (HIVE). These can promote macrop
Publikováno v:
Journal of neurovirology. 6
Viral and cellular products from HIV-1-infected and/or immune competent mononuclear phagocytes (MP) (brain macrophages and microglia) affect neuronal function during HIV-1-associated dementia (HAD). Neurotoxic MP factors include, but are not limited