Výsledky vyhledávání

A gel electrophoresis method for detection of mitochondrial DNA mutation (3243 tRNA(Leu (UUR))) applied to a Norwegian family with diabetes mellitus and hearing loss

Autor: M Akbari, H E Krokan, J Sagen, Camilla Skjelbred, I Følling

Publikováno v: Scandinavian journal of clinical and laboratory investigation. 64(2)

Blood cells of selected patients from a large Norwegian family with maternally transmitted diabetes mellitus, hearing loss and muscular dysfunction were screened for possible A3243G mutation tRNA(Leu (UUR)) in mitochondrial DNA. We selected 7 patient

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::767c6159b63da57d99d86e6d7ce317e1
https://pubmed.ncbi.nlm.nih.gov/15115244

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Properties and functions of human uracil-DNA glycosylase from the UNG gene

Autor: H E, Krokan, M, Otterlei, H, Nilsen, B, Kavli, F, Skorpen, S, Andersen, C, Skjelbred, M, Akbari, P A, Aas, G, Slupphaug

Publikováno v: Progress in nucleic acid research and molecular biology. 68

The human UNG-gene at position 12q24.1 encodes nuclear (UNG2) and mitochondrial (UNG1) forms of uracil-DNA glycosylase using differentially regulated promoters, PA and PB, and alternative splicing to produce two proteins with unique N-terminal sortin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::01f66e779ae2eaf4ab68f5b3392e3aed
https://pubmed.ncbi.nlm.nih.gov/11554311

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Cell-specific enhancement of doxorubicin toxicity in human tumour cells by docosahexaenoic acid

Autor: P K, Rudra, H E, Krokan

Publikováno v: Anticancer research. 21(1A)

We examined the cytotoxicity of doxorubicin alone, or in combination with docosahexaenoic acid (22:6 n-3), in glioblastoma cell lines A-172 and U-87 MG and bronchial carcinoma cell lines A-427 and SK-LU-1. For both glioblastoma cell lines we found an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bcfc71a6e382bdede846def9fd1bce46
https://pubmed.ncbi.nlm.nih.gov/11299749

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Acrolein cytotoxicity and glutathione depletion in n-3 fatty acid sensitive- and resistant human tumor cells

Autor: P K, Rudra, H E, Krokan

Publikováno v: Anticancer research. 19(1A)

Acrolein is a highly reactive unsaturated aldehyde formed endogenously and present in the environment. Acrolein efficiently reduces glutathione-contents and is highly cytotoxic in two lung carcinoma cell lines (A-427 and SK-LU-1) and the glioblastoma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::97a731597b7661669ea5f3889749b52e
https://pubmed.ncbi.nlm.nih.gov/10226583

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Fading correction for fluorescence quantitation in confocal microscopy

Autor: T A, Nagelhus, G, Slupphaug, H E, Krokan, T, Lindmo

Publikováno v: Cytometry. 23(3)

Quantitative analysis in confocal microscopy meets with several problems such as fading of the fluorophore during scanning and attenuation of the fluorescence in thick tissue specimens. The present study reports a quantitative investigation of the en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7a14dcb56bfef1d4c882de09148d3419
https://pubmed.ncbi.nlm.nih.gov/8974864

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The inhibitory effect of conjugated dienoic derivatives (CLA) of linoleic acid on the growth of human tumor cell lines is in part due to increased lipid peroxidation

Autor: S, Schønberg, H E, Krokan

Publikováno v: Anticancer research. 15(4)

We have examined the effects of linoleic acid, LA (18:2 n-6) and its naturally occurring conjugated derivatives (CLA) on the growth of three different lung adenocarcinoma cell lines (A-427, SK-LU-1, A549) and one human glioblastoma cell line (A-172).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::13b842394e5fb5d0c0fa893b3720667a
https://pubmed.ncbi.nlm.nih.gov/7654003

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DNA repair in mammalian tissues and cells

Autor: H E, Krokan, L C, Olsen, R, Aasland, G, Volden, G, Eggset, B, Myrnes, B, Johansen, A, Haugen, D E, Helland

Publikováno v: Basic life sciences. 53

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9da27242f7cafc52a05e034ae12bf3c8
https://pubmed.ncbi.nlm.nih.gov/2282034

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Erratum: Sequence variations in the UDP-glucuronosyltransferase 2B7 (UGT2B7) gene: identification of 10 novel single nucleotide polymorphisms (SNPs) and analysis of their relevance to morphine glucuronidation in cancer patients

Autor: M Holthe, T N Rakvág, P Klepstad, J R Idle, S Kaasa, H E Krokan, F Skorpen

Publikováno v: The Pharmacogenomics Journal. 3:248-248

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ebe34e3e7d63b95a2295be5d8979a1d2
https://doi.org/10.1038/sj.tpj.6500190

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Purification and determination of the NH2-terminal amino acid sequence of uracil-DNA glycosylase from human placenta

Autor: C U, Wittwer, G, Bauw, H E, Krokan

Publikováno v: Biochemistry. 28(2)

Uracil-DNA glycosylase has been purified approximately 130,000-fold from extracts of human placenta. Although all of the uracil-DNA glycosylase activity coeluted through six chromatographic steps, at least four distinct peaks of activity were resolve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a05fa3b7b3f503d37efff267380389a8
https://pubmed.ncbi.nlm.nih.gov/2713345

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