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Akademický článek

Spatially localized phosphorous metabolism of skeletal muscle in Duchenne muscular dystrophy patients: 24-month follow-up.

Autor: M T Hooijmans, N Doorenweerd, C Baligand, J J G M Verschuuren, I Ronen, E H Niks, A G Webb, H E Kan

Publikováno v: PLoS ONE, Vol 12, Iss 8, p e0182086 (2017)

To assess the changes in phosphodiester (PDE)-levels, detected by 31P magnetic resonance spectroscopy (MRS), over 24-months to determine the potential of PDE as marker for muscle tissue changes in Duchenne Muscular Dystrophy (DMD) patients.Spatially

Externí odkaz: https://doaj.org/article/ad08d6eda20f466ab91105c46a92fd2c

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Elevated phosphodiester and T

Autor: M T, Hooijmans, E H, Niks, J, Burakiewicz, J J G M, Verschuuren, A G, Webb, H E, Kan

Publikováno v: NMR in biomedicine. 30(1)

Quantitative MRI and MRS are increasingly important as non-invasive outcome measures in therapy development for Duchenne muscular dystrophy (DMD). Many studies have focussed on individual measures such as fat fraction and metabolite levels in relatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0cb39d6e24123a5bd61a46eb08dd6f90
https://pubmed.ncbi.nlm.nih.gov/27859827

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Time-efficient measurement of multi-phase arterial spin labeling MR signal in white matter

Autor: X, Zhang, I, Ronen, H E, Kan, W M, Teeuwisse, M J P, van Osch

Publikováno v: NMR in biomedicine. 29(11)

White matter (WM) perfusion has great potential as a physiological biomarker in many neurological diseases. Although it has been demonstrated previously that arterial spin labeling magnetic resonance imaging (ASL-MRI) enables the detection of the per

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2b72b499af36c78daf0b11268a09355f
https://pubmed.ncbi.nlm.nih.gov/27594277

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Evaluation of skeletal muscle DTI in patients with duchenne muscular dystrophy

Autor: M T, Hooijmans, B M, Damon, M, Froeling, M J, Versluis, J, Burakiewicz, J J G M, Verschuuren, E H, Niks, A G, Webb, H E, Kan

Publikováno v: NMR in biomedicine. 28(11)

Diffusion tensor imaging (DTI) is a popular method to assess differences in fiber organization in diseased and healthy muscle tissue. Previous work has shown that muscle DTI measurements depend on signal-to-noise ratio (SNR), %fat, and tissue T2. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::52c52305a0744cc8209a4e24c81a350e
https://pubmed.ncbi.nlm.nih.gov/26449628

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Multi-center reproducibility of neurochemical profiles in the human brain at 7 T

Autor: B L, van de Bank, U E, Emir, V O, Boer, J J A, van Asten, M C, Maas, J P, Wijnen, H E, Kan, G, Oz, D W J, Klomp, T W J, Scheenen

Publikováno v: NMR in biomedicine. 28(3)

The purpose of this work was to harmonize data acquisition and post-processing of single voxel proton MRS ((1) H-MRS) at 7 T, and to determine metabolite concentrations and the accuracy and reproducibility of metabolite levels in the adult human brai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e1534f90a136a5fc36902bae2eba7615
https://pubmed.ncbi.nlm.nih.gov/25581510

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Muscle MRS detects elevated PDE/ATP ratios prior to fatty infiltration in Becker muscular dystrophy

Autor: B H, Wokke, M T, Hooijmans, J C, van den Bergen, A G, Webb, J J, Verschuuren, H E, Kan

Publikováno v: NMR in biomedicine. 27(11)

Becker muscular dystrophy (BMD) is characterized by progressive muscle weakness. Muscles show structural changes (fatty infiltration, fibrosis) and metabolic changes, both of which can be assessed using MRI and MRS. It is unknown at what stage of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::680e6596175ad763cde38140e326d9cd
https://pubmed.ncbi.nlm.nih.gov/25196814

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Quantitative proton MR techniques for measuring fat

Autor: H H, Hu, H E, Kan

Publikováno v: NMR in biomedicine. 26(12)

Accurate, precise, and reliable techniques for quantifying body and organ fat distributions are important tools in physiology research. They are critically needed in studies of obesity and diseases involving excess fat accumulation. Proton magnetic r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::215cb6b2e03049891f1f3a690393d0c9
https://pubmed.ncbi.nlm.nih.gov/24123229

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