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Palosuran inhibits binding to primate UT receptors in cell membranes but demonstrates differential activity in intact cells and vascular tissues

Autor: D J, Behm, J J, McAtee, J W, Dodson, M J, Neeb, H E, Fries, C A, Evans, R R, Hernandez, K D, Hoffman, S M, Harrison, J M, Lai, C, Wu, N V, Aiyar, E H, Ohlstein, S A, Douglas

Publikováno v: British journal of pharmacology. 155(3)

The recent development of the UT ligand palosuran (1-[2-(4-benzyl-4-hydroxy-piperidin-1-yl)-ethyl]-3-(2-methyl-quinolin-4-yl)-urea sulphate salt) has led to the proposition that urotensin-II (U-II) plays a significant pathological role in acute and c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9940b321f206152091724b5bba433860
https://pubmed.ncbi.nlm.nih.gov/18587423

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