Výsledky vyhledávání - "H E, Blythman"

Thy 1.2+ leukemia cells eradicated from in vitro leukemia-bone marrow cell mixtures by antibody-toxin conjugates

Autor: M, Colombatti, A, Colombatti, H E, Blythman, C, Bron

Publikováno v: Journal of the National Cancer Institute. 72(5)

A conjugate constituted by a monoclonal anti-Thy 1.2 antibody chemically coupled to the toxic subunit of ricin was synthesized. The conjugate was specifically cytotoxic for Thy 1.2+ (EL 4) but not for Thy 1.2- (BW5147) thymoma cells. In vitro treatme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d8a32f20b16a7ec91081bfa95ce5f798
https://pubmed.ncbi.nlm.nih.gov/6585586

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Present potential of immunotoxins

Autor: P, Poncelet, H E, Blythman, D, Carriere, P, Casellas, D, Dussossoy, O, Gros, P, Gros, F K, Jansen, J C, Laurent, M C, Liance

Publikováno v: Behring Institute Mitteilungen. (74)

Immuno-a-toxins (I-a-T) are hybrid molecules designed for a more selective therapy of cancer, which combine an antibody preferentially directed against tumour cells and the A-chain of the toxin ricin. Although a majority of them are highly and select

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c9ffe01a221708e10ee0eefd69bb8cb9
https://pubmed.ncbi.nlm.nih.gov/6383330

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Immunotoxins in Cancer Therapy

Autor: J. M. Derocq, H. E. Blythman, P. Gros, B. Bourrie, G. Richer, P. Casellas, G. Laurent, C. Blazy, H. Vidal, P. Carayon, F. K. Jansen, O. Gros, D. Dussossoy

Publikováno v: Targeting of Drugs ISBN: 9781468455762

Immunotoxins (ITs) have now been studied for more than 10 years. They were found to be active under in vitro conditions and were utilized with success for the ex vivo pretreatment of human bone marrow transplantations. The new challenge today is to r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f340f6e9063fdfb258ae2c9665c0705b
https://doi.org/10.1007/978-1-4684-5574-8_7

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Techniques for Ex-Vivo Bone Marrow Treatment with Immunotoxins

Autor: P. Casellas, H. E. Blythman, F. Jansen, G. Laurent, J. M. Derocq

Publikováno v: Targeting of Drugs ISBN: 9781468455762

The high in vitro potency of immunotoxins (ITs) demonstrated by several laboratories (Moller, 1982; Moolten et al, 1982; Neville and York, 1982; Raso, 1982; Thorpe and Ross, 1982; Vitetta et al, 1982; Jansen et al, 1982) is already used for ex-vivo b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5d1a18e0c82340bb3d44414d0ce60262
https://doi.org/10.1007/978-1-4684-5574-8_8

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[Immunotoxins]

Autor: F K, Jansen, H E, Blythman, D, Carrière, P, Casellas, D, Dussossoy, O, Gros, P, Gros, J C, Laurent, F, Paolucci, B, Pau, P, Poncelet, G, Richer, H, Vidal, G A, Voisin

Publikováno v: Bulletin du cancer. 70(3)

Immunotoxins are conjugates between antibodies especially directed against cancer cells and a subunit of a powerful toxin. We used the A-chain of ricin. These conjugates are specifically cytotoxic when used at very low concentrations in vitro and can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2469d583064d838775850b9781cf6956
https://pubmed.ncbi.nlm.nih.gov/6882931

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