Výsledky vyhledávání - "H E, Akselsen"

Transcriptome profiling of human thymic CD4+ and CD8+ T cells compared to primary peripheral T cells

Autor: Ingvild Synnøve Matre Gabrielsen, Hanna Helgeland, Benedicte A. Lie, Siri Tennebø Flåm, Arvind Y. M. Sundaram, H E Akselsen

Publikováno v: BMC Genomics, Vol 21, Iss 1, Pp 1-15 (2020)
BMC Genomics

Background The thymus is a highly specialized organ of the immune system where T cell precursors develop and differentiate into self-tolerant CD4+ or CD8+ T cells. No studies to date have investigated how the human transcriptome profiles differ, betw

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a09db3b472c779b5a322179e76e7be91
https://doi.org/10.21203/rs.2.18314/v2

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Transcriptomes of antigen presenting cells in human thymus

Autor: Isaac Snowhite, H E Akselsen, Hanna Helgeland, Arvind Y. M. Sundaram, Siri Tennebø Flåm, Benedicte A. Lie, Ingvild Synnøve Matre Gabrielsen, Hans Christian Dalsbotten Aass, Alberto Pugliese

Publikováno v: PLoS ONE, Vol 14, Iss 7, p e0218858 (2019)
PLoS ONE

Antigen presenting cells (APCs) in the thymus play an essential role in the establishment of central tolerance, i.e. the generation of a repertoire of functional and self-tolerant T cells to prevent autoimmunity. In this study, we have compared the t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa4613ccd9df9a79fb8ff8347028925c
https://doi.org/10.1371/journal.pone.0218858

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HLA-DRB1, -DQA1 and -DQB1 Alleles and Haplotypes in First-Generation Pakistani Immigrants in Norway

Autor: Kjersti S. Rønningen, Trond Rasmussen, S. E. Yap, Babill Stray-Pedersen, K. Brandal, A. Stormyr, H E Akselsen, Benedicte A. Lie

Publikováno v: Scandinavian Journal of Immunology. 75:426-430

Human leucocyte antigen (HLA) polymorphisms among immigrants from Pakistan have not been well investigated. Immigration to Norway started in the late 1960s for working purposes. From 1975, immigration was mainly for marriages and family reunion. When

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::42a48113c4766696047f39a0dfdf943f
https://doi.org/10.1111/j.1365-3083.2011.02669.x

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HLA-DRB1, -DQA1 and -DQB1 alleles and haplotypes in first-generation Pakistani immigrants in Norway

Autor: K S, Rønningen, S E, Yap, K, Brandal, A, Stormyr, B A, Lie, T, Rasmussen, B, Stray-Pedersen, H E, Akselsen

Publikováno v: Scandinavian journal of immunology. 75(4)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cb23b65655feab3f98173321522903b4
https://pubmed.ncbi.nlm.nih.gov/22171671

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FTO genotype and weight gain in obese and normal weight adults from a Norwegian population based cohort (the HUNT study)

Autor: H E Akselsen, Dag E. Undlien, Jostein Holmen, Teresia Wangensteen, Thore Egeland, Lars Retterstøl

Publikováno v: Experimental and clinical endocrinologydiabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. 118(9)

The fat mass and obesity associated gene ( FTO) is associated with bodyweight and obesity. The aim of this study was to investigate if FTO genotype affects weight gain in adulthood. We investigated the weight development over a period of 11 years in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32b774b14147895f7376027660cbcc00
https://pubmed.ncbi.nlm.nih.gov/20373279

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Reproducible association with type 1 diabetes in the extended class I region of the major histocompatibility complex

Autor: Marita Olsson, Ingrid Kockum, Anne Cambon-Thomsen, Marte K. Viken, Erik Thorsby, Benedicte A. Lie, Anne Blomhoff, J Nerup, Dag E. Undlien, H E Akselsen, Flemming Pociot

Publikováno v: Genes and immunity. 10(4)

The high-risk human leukocyte antigen (HLA)-DRB1, DQA1 and DQB1 alleles cannot explain the entire type 1 diabetes (T1D) association observed within the extended major histocompatibility complex. We have earlier identified an association with D6S2223,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2346c21ed004bbb535b4afc80764fabe
https://pubmed.ncbi.nlm.nih.gov/19295542

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A TLR2 polymorphism is associated with type 1 diabetes and allergic asthma

Autor: Geir Joner, Thore Egeland, H E Akselsen, K-H. Carlsen, Kai-Håkon Carlsen, Dag E. Undlien, Kristina Gervin, Marit Bjørnvold, Knut Dahl-Jørgensen, Monica Cheng Munthe-Kaas, Pål R. Njølstad

Publikováno v: Genes and immunity. 10(2)

Type 1 diabetes (T1D) and allergic asthma are immune-mediated diseases. Pattern recognition receptors are proteins expressed by cells in the immune system to identify microbial pathogens and endogenous ligands. Toll-like receptors (TLRs) and CD14 are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98ae8431fd8fb3ede2539492779e3a53
https://pubmed.ncbi.nlm.nih.gov/19148143

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HLA associations in type 1 diabetes among patients not carrying high-risk DR3-DQ2 or DR4-DQ8 haplotypes

Autor: D E, Undlien, I, Kockum, K S, Rønningen, R, Lowe, C B, Saanjeevi, J, Graham, B A, Lie, H E, Akselsen, A, Lernmark, E, Thorsby

Publikováno v: Tissue antigens. 54(6)

Type 1 diabetes is a complex disease where numerous genes are involved in the pathogenesis. Genes that account for approximately 50% of the familial clustering of the disease are located within or in the vicinity of the HLA complex on chromosome 6. S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::55a48a7fbe533f9be9490fe038c0f106
https://pubmed.ncbi.nlm.nih.gov/10674967

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A gene telomeric of the HLA class I region is involved in predisposition to both type 1 diabetes and coeliac disease

Autor: B A, Lie, L M, Sollid, H, Ascher, J, Ek, H E, Akselsen, K S, Rønningen, E, Thorsby, D E, Undlien

Publikováno v: Tissue antigens. 54(2)

We have recently shown that an as yet unidentified gene within or in the vicinity of the HLA complex, in linkage disequilibrium with microsatellite D6S2223, modifies the risk to develop type 1 diabetes independently of HLA-DR and -DQ genes. This micr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8676436879d4c8289e186a90daa24949
https://pubmed.ncbi.nlm.nih.gov/10488743

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