Zobrazeno 1 - 10
of 72
pro vyhledávání: '"H D Perez"'
Autor:
Joseph Hesselgesser, Mary Rosser, M. Liang, Richard Horuk, R. M. Snider, Ghannam Ameen F, John G. Bauman, P. J. Kretschmer, Ng Howard P, Michael M. Morrissey, H. D. Perez, Imadul Islam, Laura Dunning, Karen May, Haifeng Pu
Publikováno v:
European Journal of Pharmacology. 389:41-49
The species specificity of a small molecule antagonist for the human CCR1 chemokine receptor, 2-2-diphenyl-5-(4-chlorophenyl)piperidin-1-yl)valeronitrile (CCR1 antagonist 1), has been examined using cloned CCR1 receptors from various species. The com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d428713d410eca88d08e68565d0fb58e
https://doi.org/10.1016/s0014-2999(99)00863-8
https://doi.org/10.1016/s0014-2999(99)00863-8
Autor:
Karen May, John G. Bauman, Joseph Hesselgesser, Michael M. Morrissey, Ng Howard P, Richard Horuk, M. Liang, Imadul Islam, R. M. Snider, H. D. Perez, Ghannam Ameen F
Publikováno v:
Journal of Medicinal Chemistry. 42:4680-4694
Ligands for the CCR1 receptor (MIP-1alpha and RANTES) have been implicated in a number of chronic inflammatory diseases, most notably multiple sclerosis and rheumatoid arthritis. Because these ligands share a common receptor, CCR1, we sought to disco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b22aa4c7750092a1000f22c3df454c21
https://doi.org/10.1021/jm990316l
https://doi.org/10.1021/jm990316l
Publikováno v:
Biochemical and Biophysical Research Communications. 255:539-544
Human type I interferons (IFN) require two receptor chains, IFNAR1 and IFNAR2c for high affinity (pM) binding and biological activity. Our previous studies have shown that the ligand dependent assembly of the type I IFN receptor chains is not identic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf160cb5a656329765e87ee31c5d470d
https://doi.org/10.1006/bbrc.1998.0105
https://doi.org/10.1006/bbrc.1998.0105
Autor:
Ghannam Ameen F, Wei Zheng, Dennis D. Taub, John G. Bauman, M. Liang, H. D. Perez, Monahan Sean D, Michael M. Morrissey, Mary Rosser, Ng Howard P, Richard Horuk, Joseph Hesselgesser, Karen May, Imadul Islam, R. M. Snider, Guo Ping Wei
Publikováno v:
Journal of Biological Chemistry. 273:15687-15692
The CC chemokines macrophage inflammatory protein-1alpha (MIP-1alpha) and RANTES (regulated on activation normal T cell expressed) have been implicated in rheumatoid arthritis and multiple sclerosis. Since their effects are mediated through the CCR1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a83bb79b12767a5582a1f5b5eb1cf33
https://doi.org/10.1074/jbc.273.25.15687
https://doi.org/10.1074/jbc.273.25.15687
Autor:
R Horuk, A W Martin, Z Wang, L Schweitzer, A Gerassimides, H Guo, Z Lu, J Hesselgesser, H D Perez, J Kim, J Parker, T J Hadley, S C Peiper
Publikováno v:
The Journal of Immunology. 158:2882-2890
IL-8 is expressed by activated and neoplastic astrocytes and enhances the survival of hippocampal neurons in vitro. Since mRNA encoding chemokine receptors have been demonstrated in brain, the expression of chemokine receptors by specific cell types
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::294faf5a2bc195f640c742db6bec4868
https://doi.org/10.4049/jimmunol.158.6.2882
https://doi.org/10.4049/jimmunol.158.6.2882
Publikováno v:
Journal of Biological Chemistry. 270:26033-26036
The type I interferon (IFN) receptor complex is assumed to be composed of multiple protein subunits. Recently, two proteins have been identified as potential receptor components, both of which share a high degree of structural homology with the immun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b831f0797003ffbe1079ff39e127d820
https://doi.org/10.1074/jbc.270.44.26033
https://doi.org/10.1074/jbc.270.44.26033
Publikováno v:
The Journal of Experimental Medicine
Lipoxin A4 (LXA4) triggers selective responses with human neutrophils that are pertussis toxin sensitive and binds to high affinity receptors (Kd = 0.5 +/- 0.3 nM) that are modulated by stable analogues of guanosine 5'-triphosphate (GTP). Here, we ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34c92f6363b132eb872719e1b0836dcc
https://doi.org/10.1084/jem.180.1.253
https://doi.org/10.1084/jem.180.1.253
Publikováno v:
Journal of Biological Chemistry. 268:2292-2295
We have begun to study the structural requirements for the binding of formyl peptides to their specific receptors. As an initial approach, we constructed C5a-formyl peptide receptor chimeras. Unique (and identical) restriction sites were introduced w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50d1ca9bc1b67c62a10a05d138468aa9
https://doi.org/10.1016/s0021-9258(18)53771-6
https://doi.org/10.1016/s0021-9258(18)53771-6
Publikováno v:
Biochemistry. 31:11595-11599
Recently we reported that, in HL-60 cells, transcription of the formyl peptide receptor (FPR) gene can be up- and downregulated by agents that induce differentiation of HL-60 cells into neutrophils. To begin studying the mechanisms involved in regula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6b8a308789284e43fe778bb70410311
https://doi.org/10.1021/bi00161a044
https://doi.org/10.1021/bi00161a044
Publikováno v:
Journal of Biological Chemistry. 267:358-363
When incubated with N6-2'-O-dibutyryladenosine 3',5'-cyclic monophosphate (dbcAMP), HL-60 cells expressed formyl peptide receptor (FPR) (as assessed by ligand binding) and FPR transcripts in a time- and concentration-dependent fashion. Experiments us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4ff843b7bb9ca1e9ae69fb77546b5bb
https://doi.org/10.1016/s0021-9258(18)48502-x
https://doi.org/10.1016/s0021-9258(18)48502-x