Zobrazeno 1 - 10
of 25
pro vyhledávání: '"H D, Connor"'
Autor:
J A Raleigh, Y. Iimuro, C Wall, K T Knecht, H D Connor, Y. Adachi, R P Mason, G E Arteel, Moritz V. Frankenberg, D. Forman, B. U. Bradford, Ronald G. Thurman
Publikováno v:
Frontiers in Bioscience. 4:e42-46
Alcohol treatment results in increases in the release of endotoxin from gut bacteria and membrane permeability of the gut to endotoxin, or both. Females are more sensitive to these changes. Elevated levels of endotoxin activate Kupffer cells to relea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c961b28ea3451ed865f921f52a65933
https://doi.org/10.2741/a478
https://doi.org/10.2741/a478
Publikováno v:
Transplant International. 5:S329-S335
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26cc7c716fad4a00869fdf6b7c7c5101
https://doi.org/10.1111/tri.1992.5.s1.329
https://doi.org/10.1111/tri.1992.5.s1.329
Autor:
T G, Lehmann, M D, Wheeler, R F, Schwabe, H D, Connor, R, Schoonhoven, H, Bunzendahl, D A, Brenner, R, Jude Samulski, Z, Zhong, R G, Thurman
Publikováno v:
Hepatology (Baltimore, Md.). 32(6)
Oxygen-derived free radicals play a central role in reperfusion injury after organ transplantation, and fatty livers are particularly susceptible. Endogenous radical scavengers such as superoxide dismutase (SOD) degrade these radicals; however, SOD i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::306813233fc7a7762037aea5b9658a8d
https://pubmed.ncbi.nlm.nih.gov/11093732
https://pubmed.ncbi.nlm.nih.gov/11093732
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 293(1)
Free radical formation caused by chronic ethanol administration could activate transcription factors such as nuclear factor-kappaB (NF-kappaB), which regulates production of inflammatory cytokines. Xanthine oxidase is one potential source of reactive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3fe9e971126fb110a0c1dd69c2c5cb07
https://pubmed.ncbi.nlm.nih.gov/10734182
https://pubmed.ncbi.nlm.nih.gov/10734182
Autor:
Z, Zhong, G E, Arteel, H D, Connor, P, Schemmer, S C, Chou, J A, Raleigh, R P, Mason, J J, Lemasters, R G, Thurman
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 290(2)
Disturbances in hepatic microcirculation increase graft injury and failure; therefore, this study evaluates the effects of ethanol on microcirculation after liver transplantation. Donor rats were given one dose of ethanol (5 g/kg) by gavage 20 h befo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b9e8274d2507ed6d59bf239cc3e4fa6a
https://pubmed.ncbi.nlm.nih.gov/10411569
https://pubmed.ncbi.nlm.nih.gov/10411569
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 290(1)
Kupffer cell-dependent injury in livers gently manipulated during harvest develops upon transplantation; however, underlying mechanisms remain unknown. Thus, the purpose of this study was to identify factors involved in mechanisms of injury. Livers f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::eab32f391ce37c24b81f95427db91ddb
https://pubmed.ncbi.nlm.nih.gov/10381781
https://pubmed.ncbi.nlm.nih.gov/10381781
Publikováno v:
Transplantation. 66(11)
Ethanol increases primary graft failure after liver transplantation, yet whether it acts via mechanisms involving fat accumulation remains unclear.Rats were pair-fed a modified Lieber-DeCarli liquid diet containing 35% (high-fat) or 12% (low-fat) of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8e0425de8bb1fd942be06373280a6664
https://pubmed.ncbi.nlm.nih.gov/9869083
https://pubmed.ncbi.nlm.nih.gov/9869083
Autor:
R G, Thurman, B U, Bradford, Y, Iimuro, K T, Knecht, G E, Arteel, M, Yin, H D, Connor, C, Wall, J A, Raleigh, M V, Frankenberg, Y, Adachi, D T, Forman, D, Brenner, M, Kadiiska, R P, Mason
Publikováno v:
Journal of gastroenterology and hepatology.
Previous research from this laboratory using a continuous enteral ethanol (EtOH) administration model demonstrated that Kupffer cells are pivotal in the development of EtOH-induced liver injury. When Kupffer cells were destroyed using gadolinium chlo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::091ad3681d900460c3005425eb3ed51a
https://pubmed.ncbi.nlm.nih.gov/9792033
https://pubmed.ncbi.nlm.nih.gov/9792033
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 282(3)
Tacrine is an acetylcholinesterase inhibitor approved for the treatment of Alzheimer's disease. Unfortunately, reversible hepatotoxicity in about 30% of patients at therapeutic doses limits clinical use. The purpose of this study was to develop and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d61d1c42c53e5534b1e8e75b26a12018
https://pubmed.ncbi.nlm.nih.gov/9316876
https://pubmed.ncbi.nlm.nih.gov/9316876
Autor:
R G, Thurman, W, Gao, H D, Connor, Y, Adachi, R F, Stachlewitz, Z, Zhong, K T, Knecht, B U, Bradford, R P, Mason, J J, Lemasters
Publikováno v:
Advances in experimental medicine and biology. 387
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c836179b90bbd83b7aa25b439c0c21e4
https://pubmed.ncbi.nlm.nih.gov/8794217
https://pubmed.ncbi.nlm.nih.gov/8794217