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Immunomodulatory effects of transforming growth factor-beta on T lymphocytes. Induction of CD8 expression in the CTLL-2 cell line and in normal thymocytes

Autor: T H Inge, K M McCoy, B M Susskind, S K Barrett, G Zhao, H D Bear

Publikováno v: The Journal of Immunology. 148:3847-3856

We investigated the role of transforming growth factor-beta 1 (TGF-beta) in regulation of T cell growth and differentiation. Treatment of CTLL-2 cells with TGF-beta inhibited IL-2-dependent proliferation and caused morphologic changes as well as incr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e164d5ac945b738c14ba5d0a9f01789e
https://doi.org/10.4049/jimmunol.148.12.3847

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Phase Ib trial of bryostatin 1 in patients with refractory malignancies

Autor: S, Grant, J, Roberts, E, Poplin, M B, Tombes, B, Kyle, D, Welch, M, Carr, H D, Bear

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 4(3)

A Phase Ib trial of bryostatin 1, a macrocyclic lactone and protein kinase C (PKC) activator, was conducted in patients with refractory nonhematological malignancies with the primary goal of determining whether down-regulation of peripheral blood mon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fab429e0390da0cdf5b2580d3734d015
https://pubmed.ncbi.nlm.nih.gov/9533528

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Ex vivo expansion of tumor-draining lymph node cells using compounds which activate intracellular signal transduction. I. Characterization and in vivo anti-tumor activity of glioma-sensitized lymphocytes

Autor: N G, Baldwin, C D, Rice, T M, Tuttle, H D, Bear, J I, Hirsch, R E, Merchant

Publikováno v: Journal of neuro-oncology. 32(1)

It has been shown that adoptive immunotherapy can be curative for established malignant tumors. The key to this treatment lies in obtaining sufficient numbers of lymphocytes which are sensitized to recognize tumor antigens and carry out immunological

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dbbecfe0f6a6216409698b978b12ad76
https://pubmed.ncbi.nlm.nih.gov/9049859

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Ex vivo expansion of tumor-draining lymph node cells using compounds which activate intracellular signal transduction. II. Cytokine production and in vivo efficacy of glioma-sensitized lymphocytes

Autor: C D, Rice, N G, Baldwin, R T, Biron, H D, Bear, R E, Merchant

Publikováno v: Journal of neuro-oncology. 32(1)

We have investigated the anti-tumor activity of ex vivo activated and expanded T cells which had been sensitized in vivo to one of two different syngeneic rat glioma cell lines; D74 or RT-2. Rats were sensitized by inoculation of irradiated tumor cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4f3043966bd2b818db51c512560667d2
https://pubmed.ncbi.nlm.nih.gov/9049860

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Biologic therapy of melanoma with cytokines and lymphocytes

Autor: H D, Bear, G G, Hamad, P J, Kostuchenko

Publikováno v: Seminars in surgical oncology. 12(6)

Melanoma has a somewhat unpredictable behavior, and spontaneous regressions do occasionally occur. Many have surmised that these are the result of immunologic attack by the host. Immunologic treatment has been more successful for melanoma than for mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5956c9bb5955e2ec03b58728f0160d02
https://pubmed.ncbi.nlm.nih.gov/8914208

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Effect of AS101 on bryostatin 1-mediated differentiation induction, cell cycle arrest, and modulation of drug-induced apoptosis in human myeloid leukemia cells

Autor: A S, Rao, A J, Freemerman, W D, Jarvis, J, Chelliah, H D, Bear, R, Mikkelsen, S, Grant

Publikováno v: Leukemia. 10(7)

Based upon earlier reports of synergism in cells of lymphoid origin, we have examined interactions between the organotellurium compound AS101 and the protein kinase C (PKC) activator bryostatin 1 with respect to differentiation and Ara-C-induced apop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f266962a24bb1513f1afdd997bfbd0ad
https://pubmed.ncbi.nlm.nih.gov/8683995

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