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Autor:
Achuthanunni Chokkathukalam, David A. Fidock, Marco Biddau, T. R. Santha Kumar, Stephen L. Hoffman, Lewis J King, Larissa M. Laine, Graham H. Coombs, Geoffrey I. McFadden, Philipp P. Henrich, Michael P. Barrett, Kim Lee Sim, Gavin Blackburn, Tao Li, Lilach Sheiner, Sylke Müller
Publikováno v:
International Journal for Parasitology
Graphical abstract
Highlights • Apicoplast LipB deletion leads to changed antioxidant expression that precedes and coincides with accelerated differentiation. • 3D7 Plasmodium exhibits changes in glycolysis and tricarboxylic acid cycle activ
Highlights • Apicoplast LipB deletion leads to changed antioxidant expression that precedes and coincides with accelerated differentiation. • 3D7 Plasmodium exhibits changes in glycolysis and tricarboxylic acid cycle activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1af396c0cc1a2654b6cf40fde8641b1
https://doi.org/10.1016/j.ijpara.2020.10.011
https://doi.org/10.1016/j.ijpara.2020.10.011
Autor:
Robert H. Coombs
Addiction Recovery Tools: A Practical Handbook presents verified recovery tools with a methodical'when and how'approach for each available tool. Including both Western and Eastern methods, the book catalogs the motivational, medical-pharmaceutical, c
Autor:
Gareth D Westrop, Lijie Wang, Gavin J Blackburn, Tong Zhang, Liang Zheng, David G Watson, Graham H Coombs
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0189072 (2017)
Trichomonas vaginalis and Tritrichomonas foetus are pathogens that parasitise, respectively, human and bovine urogenital tracts causing disease. Using LC-MS, reference metabolomic profiles were obtained for both species and stable isotope labelling w
Externí odkaz:
https://doaj.org/article/82ad25d435ed4a0bb014aa817adaea9d
Autor:
Gareth D Westrop, Roderick A M Williams, Lijie Wang, Tong Zhang, David G Watson, Ana Marta Silva, Graham H Coombs
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0136891 (2015)
Comparative genomic analyses of Leishmania species have revealed relatively minor heterogeneity amongst recognised housekeeping genes and yet the species cause distinct infections and pathogenesis in their mammalian hosts. To gain greater information
Externí odkaz:
https://doaj.org/article/04e88e58662649bfa6f2649a6e1cf7d0
Autor:
Janet Storm, Sonal Sethia, Gavin J Blackburn, Achuthanunni Chokkathukalam, David G Watson, Rainer Breitling, Graham H Coombs, Sylke Müller
Publikováno v:
PLoS Pathogens, Vol 10, Iss 1, p e1003876 (2014)
Phospoenolpyruvate carboxylase (PEPC) is absent from humans but encoded in the Plasmodium falciparum genome, suggesting that PEPC has a parasite-specific function. To investigate its importance in P. falciparum, we generated a pepc null mutant (D10(
Externí odkaz:
https://doaj.org/article/d2a64c2bb86a48999a10a5353d42d4ef
Autor:
Wagner A S Judice, Marcella A Manfredi, Gerson P Souza, Thiago M Sansevero, Paulo C Almeida, Cláudio S Shida, Tarsis F Gesteira, Luiz Juliano, Gareth D Westrop, Sanya J Sanderson, Graham H Coombs, Ivarne L S Tersariol
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80153 (2013)
Cysteine protease B is considered crucial for the survival and infectivity of the Leishmania in its human host. Several microorganism pathogens bind to the heparin-like glycosaminoglycans chains of proteoglycans at host-cell surface to promote their
Externí odkaz:
https://doaj.org/article/0147605441e94b73a97ea1a6f9f4b77a
Autor:
Jörg Schröder, Sandra Noack, Richard J Marhöfer, Jeremy C Mottram, Graham H Coombs, Paul M Selzer
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77460 (2013)
Cysteine proteases of the papain superfamily are present in nearly all eukaryotes. They play pivotal roles in the biology of parasites and inhibition of cysteine proteases is emerging as an important strategy to combat parasitic diseases such as slee
Externí odkaz:
https://doaj.org/article/49234cef8f6e48de9c54a9bfe0246173
Autor:
Santha T.R. Kumar, Achuthanunni Chokkathukalam, B. Kim Lee Sim, Tao Li, Stephen L. Hoffman, Philipp P. Henrich, Marco Biddau, Gavin Blackburn, Sylke Müller, Lilach Sheiner, Larissa M. Laine, Graham H. Coombs, Geoffrey I. McFadden, David A. Fidock, Michael P. Barrett
Malaria is still one of the most important global infectious diseases. Emergence of drug resistance and a shortage of new efficient anti-malarials continue to hamper a malaria eradication agenda. Malaria parasites are highly sensitive to changes in r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a2da55ce2090c84ac7361a73dd86a31
https://doi.org/10.1101/2020.05.17.099630
https://doi.org/10.1101/2020.05.17.099630
Autor:
Saskia Decuypere, Manu Vanaerschot, Kirstyn Brunker, Hideo Imamura, Sylke Müller, Basudha Khanal, Suman Rijal, Jean-Claude Dujardin, Graham H Coombs
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 6, Iss 2, p e1514 (2012)
The evolution of drug-resistance in pathogens is a major global health threat. Elucidating the molecular basis of pathogen drug-resistance has been the focus of many studies but rarely is it known whether a drug-resistance mechanism identified is uni
Externí odkaz:
https://doaj.org/article/3cc11c779a5c45b59e37c9791843ce84