Výsledky vyhledávání - "H C van Beeren"

Amiodarone inhibits thyroidal iodide transport in vitro by a cyclic adenosine 5'-monophosphate- and iodine-independent mechanism

Autor: S. Tedelind, Fredrik Larsson, H C van Beeren, Mikael Nilsson, E. Nyström, W. M. Wiersinga, C. Johanson

Publikováno v: Endocrinology, 147(6), 2936-2943. The Endocrine Society

Thyroid side effects are common in patients treated for cardiac arrhythmias with amiodarone (AM). A major disturbance is inhibited thyroidal radioiodine uptake in AM-induced thyrotoxicosis, which makes 131I therapy ineffective. On the other hand, fai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50be9a241f3a246c423aa54a718bda4b
https://doi.org/10.1210/en.2005-1246

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Differential effects of fasting vs food restriction on liver thyroid hormone metabolism in male rats

Autor: H C van Beeren, A Boelen, E. M. de Vries, M T Ackermans, Andries Kalsbeek, E Fliers

Publikováno v: Journal of endocrinology, 224(1), 25-35. Society for Endocrinology
The Journal of endocrinology, 224(1), 25-35. Society for Endocrinology

A variety of illnesses that leads to profound changes in the hypothalamus–pituitary–thyroid (HPT) are axis collectively known as the nonthyroidal illness syndrome (NTIS). NTIS is characterized by decreased tri-iodothyronine (T3) and thyroxine (T4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e02b97c083197531308d3c4d76a64660
https://pubmed.ncbi.nlm.nih.gov/25349245

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Fasting-induced changes in hepatic thyroid hormone metabolism in male rats are independent of autonomic nervous input to the liver

Autor: Leslie Eggels, Ellen A. Fliers, Mariëtte T. Ackermans, Anita Boelen, H C van Beeren, E. M. de Vries, Andries Kalsbeek

Publikováno v: Endocrinology, 155(12), 5033-5041. The Endocrine Society
Endocrinology. The Endocrine Society

During fasting, profound changes in the regulation of the hypothalamus-pituitary-thyroid axis occur in order to save energy and limit catabolism. In this setting, serum T3 and T4 are decreased without an appropriate TSH and TRH response reflecting ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ee975f6047f9cb7bc5dc0c5fdd3ae21
https://pure.amc.nl/en/publications/fastinginduced-changes-in-hepatic-thyroid-hormone-metabolism-in-male-rats-are-independent-of-autonomic-nervous-input-to-the-liver(55c25b3c-a464-4cff-b181-3affb430412c).html

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A survey of iodine intake and thyroid volume in Dutch schoolchildren: reference values in an iodine-sufficient area and the effect of puberty

Autor: M van Vessem, W. M. Wiersinga, M Srbecky, J Podoba, M C Platvoet-ter Schiphorst, H C van Beeren

Publikováno v: European journal of endocrinology / European Federation of Endocrine Societies, 144(6), 595-603. BioScientifica Ltd.

BACKGROUND: Iodine deficiency and endemic goiter have been reported in the past in The Netherlands, especially in the southeast. OBJECTIVE: To evaluate iodine intake and thyroid size in Dutch schoolchildren, contrasting those living in a formerly iod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99bda2c2094d6051f4821afae8bcb6db
https://doi.org/10.1530/eje.0.1440595

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Structure-function relationship of the inhibition of the 3,5,3'-triiodothyronine binding to the alpha1- and beta1-thyroid hormone receptor by amiodarone analogs

Autor: Wilmar M. Wiersinga, H C van Beeren, O. Bakker

Publikováno v: Endocrinology, 137(7), 2807-2814. The Endocrine Society

Desethylamiodarone (DEA), the major metabolite of the potent antiarrhythmic drug amiodarone (A), acts as a competitive inhibitor of T3, binding to the alpha1-thyroid hormone receptor (alpha1-T3R), but as a noncompetitive inhibitor with respect to the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80798463db8ce2879ca58ad6f79cb713
https://doi.org/10.1210/endo.137.7.8770901

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Desethylamiodarone is a noncompetitive inhibitor of the binding of thyroid hormone to the thyroid hormone beta 1-receptor protein

Autor: W. M. Wiersinga, H C van Beeren, O. Bakker

Publikováno v: Endocrinology, 134(4), 1665-1670. The Endocrine Society

It has been hypothesized that amiodarone (A), a potent antiarrythmic and antianginal drug, induces a local hypothyroid-like condition in extrathyroidal tissues. This might be related to competitive antagonism of A for the thyroid hormone receptor rep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67486281f5d373aed33702af53d9319b
https://doi.org/10.1210/endo.134.4.8137729

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Lacking thyroid hormone receptor beta gene does not influence alterations in peripheral thyroid hormone metabolism during acute illness

Autor: Anita Boelen, Olivier Chassande, W. M. Wiersinga, Joan Kwakkel, H C van Beeren

Publikováno v: Journal of endocrinology, 197(1), 151-158. Society for Endocrinology

The downregulation of liver deiodinase type 1 (D1) is supposed to be one of the mechanisms behind the decrease in serum tri-iodothyronine (T3) observed during non-thyroidal illness (NTI). Liver D1 mRNA expression is positively regulated by T3, mainly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12ed2a758850c979fd25597ceda73834
https://pure.amc.nl/en/publications/lacking-thyroid-hormone-receptor-beta-gene-does-not-influence-alterations-in-peripheral-thyroid-hormone-metabolism-during-acute-illness(dcbb6685-92ca-4884-8f70-008f89ff8806).html

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Effect of amiodarone and dronedarone administration in rats on thyroid hormone-dependent gene expression in different cardiac components

Autor: A F M Moorman, V M Christoffels, I Stoykov, H C van Beeren, O. Bakker, W. M. Wiersinga

Publikováno v: European journal of endocrinology / European Federation of Endocrine Societies, 156(6), 695-702. BioScientifica Ltd.

Objective: In view of their different actions on thyroid hormone receptor (TR) isoforms we set out to investigate whether amiodarone (AM) and dronedarone (Dron) have different and/or component-specific effects on cardiac gene expression. Design: Rats

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b66ea829a0d5109c33f34e5387cfaf3a
https://pure.amc.nl/en/publications/effect-of-amiodarone-and-dronedarone-administration-in-rats-on-thyroid-hormonedependent-gene-expression-in-different-cardiac-components(56f3cd87-f234-42ae-b34f-69be6bb4bd3b).html

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Effect of mutations in the beta1-thyroid hormone receptor on the inhibition of T3 binding by desethylamiodarone

Autor: H C van Beeren, Wilmar M. Wiersinga, V.K.K. Chatterjee, O. Bakker

Publikováno v: FEBS letters, 450(1-2), 35-38. Wiley-Blackwell

Desethylamiodarone (DEA) acts as a competitive inhibitor of triiodothyronine (T3) binding to the alpha1-thyroid hormone receptor (TR alpha1) but as a non-competitive inhibitor with respect to TR beta1. To gain insight into the position of the binding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0db4e74111794ba95513a2e054d92e26
https://pure.amc.nl/en/publications/effect-of-mutations-in-the-beta1thyroid-hormone-receptor-on-the-inhibition-of-t3-binding-by-desethylamiodarone(cae0b635-7f9c-4b75-b3ed-bc70b2e892cf).html

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