Zobrazeno 1 - 10 of 44 pro vyhledávání: '"H C Hartzell"'
1
The Best Disease-Linked Cl−ChannelhBest1Regulates CaV1 (L-type) Ca2+Channels via src-Homology-Binding Domains
Autor: Amy S. Lee, Q. Xiao, Kuai Yu, G. Cui, H. C. Hartzell
Publikováno v: The Journal of Neuroscience. 28:5660-5670
Mutations in the bestrophin-1 (Best1) gene are linked to several kinds of macular degeneration in both humans and dogs. Although bestrophins have been shown clearly to be Cl−ion channels, it is controversial whether Cl−channel dysfunction can exp
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0514a66481a24480a88a44072aebd9a6
https://doi.org/10.1523/jneurosci.0065-08.2008
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2
Effect of arachidonic acid on the L-type calcium current in frog cardiac myocytes
Autor: J Petit-Jacques, H C Hartzell
Publikováno v: The Journal of Physiology. 493:67-81
1. External application of the unsaturated fatty acid arachidonic acid (AA) to frog ventricular cells caused a large inhibition (approximately 85%) of the L-type calcium current (ICa,L) previously stimulated by the beta-adrenergic agonist isoprenalin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0485b5ab473a37f446fada4866b8f6f1
https://doi.org/10.1113/jphysiol.1996.sp021365
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3
Calphostin C, a widely used protein kinase C inhibitor, directly and potently blocks L-type Ca channels
Autor: H. C. Hartzell, A. Rinderknecht
Publikováno v: American Journal of Physiology-Cell Physiology. 270:C1293-C1299
Calphostin C is a widely used inhibitor of protein kinase C; in the past 4 years at least 350 articles have been published using this drug as a selective inhibitor of protein kinase C. In this paper, we show that calphostin C also potently inhibits c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e93d0071f274cf9f1ab430ee2578501
https://doi.org/10.1152/ajpcell.1996.270.5.c1293
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4
Activation of different Cl currents in Xenopus oocytes by Ca liberated from stores and by capacitative Ca influx
Autor: H C Hartzell
Publikováno v: The Journal of General Physiology
Xenopus oocytes are an excellent model system for studying Ca signaling. The purpose of this study was to characterize in detail the Ca-activated Cl currents evoked by injection of inositol 1,4,5-trisphosphate (IP3) into Xenopus oocytes voltage-clamp
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2d6870a7063213a3c86f34d410b5691
http://europepmc.org/articles/PMC2229319
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5
Effects of protein phosphatase and kinase inhibitors on the cardiac L- type Ca current suggest two sites are phosphorylated by protein kinase A and another protein kinase
Autor: H C Hartzell, J Petit-Jacques, Y Hirayama
Publikováno v: The Journal of General Physiology
We previously showed (Frace, A.M. and H.C. Hartzell. 1993. Journal of Physiology. 472:305-326) that internal perfusion of frog atrial myocytes with the nonselective protein phosphatase inhibitors microcystin or okadaic acid produced an increase in th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ab60a196afb8e4900152580e8a1ad16
http://europepmc.org/articles/PMC2229266
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6
Regulation of Ca2+ current in frog ventricular cardiomyocytes by guanosine 5'-triphosphate analogues and isoproterenol
Autor: H C Hartzell, T D Parsons
Publikováno v: The Journal of General Physiology
Calcium currents (ICa) were measured in frog ventricular myocytes using the whole-cell patch clamp technique and a perfused pipette. To gain insight into the role of G proteins in the regulation of ICa in intact cells, the effect of internal perfusio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c68c1403806ac04b96a30d22a138b2eb
https://doi.org/10.1085/jgp.102.3.525
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7
Rate-limiting steps in the beta-adrenergic stimulation of cardiac calcium current
Autor: Rodolphe Fischmeister, P F Méry, A M Frace, H C Hartzell
Publikováno v: The Journal of General Physiology
Fast-flow perfusion and flash photolysis of caged compounds were used to study the activation kinetics of L-type calcium current (ICa) in frog cardiac myocytes. Rapid exposure to isoproterenol (Iso) for 1 s or approximately 1 min produced similar kin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::061e621a09df073258ed425859c11434
https://doi.org/10.1085/jgp.101.3.337
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9
Sympathetic regulation of cardiac calcium current is due exclusively to cAMP-dependent phosphorylation
Autor: P F Méry, H C Hartzell, Szabo G, Rodolphe Fischmeister
Publikováno v: Nature. 351:573-576
THE positive inotropic effect of the sympathetic nervous system on the heart is partly mediated by an increase in the voltage-gated Ca2+ current (Ica) This increase is generally attributed to β-adrenergic receptor-stimulated cyclic AMP-dependent pho
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff0656c38ef90ba53c183a0f994db0f8
https://doi.org/10.1038/351573a0
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10
Alterations in Ca2+ sensitive tension due to partial extraction of C-protein from rat skinned cardiac myocytes and rabbit skeletal muscle fibers
Autor: Polly A. Hofmann, H C Hartzell, Richard L. Moss
Publikováno v: The Journal of General Physiology
C-protein, a substantial component of muscle thick filaments, has been postulated to have various functions, based mainly on results from biochemical studies. In the present study, effects on Ca(2+)-activated tension due to partial removal of C-prote
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5113b179157b229f7ec42e1ab1374579
https://doi.org/10.1085/jgp.97.6.1141
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