Zobrazeno 1 - 10
of 22
pro vyhledávání: '"H C, Krutzsch"'
Publikováno v:
Investigative ophthalmologyvisual science. 41(8)
Thrombospondin (TSP)1 is a tumor suppressor with activity that is associated with its ability to inhibit neovascularization. Previous studies have mapped this antiangiogenic activity to the type 1 repeats and the amino-terminal portion of the molecul
Publikováno v:
Cancer research. 60(2)
Although human small cell lung carcinoma (SCLC) cell lines are typically anchorage-independent and do not attach on most extracellular matrix proteins, OH-1, and several other SCLC cell lines attached on substrates coated with thrombospondin-1 (TSP1)
Publikováno v:
Laboratory investigation; a journal of technical methods and pathology. 79(3)
Although the gene responsible for multiple endocrine neoplasia, type 1 (MEN1) has been identified recently, the function of its gene product, menin, is not known. To examine menin's biological role, we created an N-terminal tagged fusion protein to f
Autor:
N, Guo, V S, Zabrenetzky, L, Chandrasekaran, J M, Sipes, J, Lawler, H C, Krutzsch, D D, Roberts
Publikováno v:
Cancer research. 58(14)
Thrombospondin 1 (TSP1) is an angiogenesis inhibitor that decreases tumor growth. We now report that TSP1 directly inhibits the proliferation of human melanoma cells. TSP1, peptides, and a recombinant fragment from the type I repeats, but not peptide
Publikováno v:
Biotechnology and bioengineering. 54(4)
A peptide termed P189, derived from the sequence of a newly discovered protein, AAMP (angio-associated migratory cell protein), contains a motif that is predicted to a bind heparin. It occurs near the amino terminal end of AAMP. Previous studies have
Publikováno v:
Cancer research. 57(9)
Thrombospondin 1 (TSP1) inhibits angiogenesis and modulates endothelial cell adhesion, motility, and growth. The antiproliferative activity of TSP1 is mimicked by synthetic peptides derived from the type I repeats of TSP1 that antagonize fibroblast g
Publikováno v:
Cancer research. 55(10)
A novel immunoglobulin-type protein expressed in blood vessels has been identified. The cDNA for AAMP (angio-associated, migratory cell protein) was first isolated from a human melanoma cell line during a search for motility-associated cell surface p
Autor:
J, Murata, H Y, Lee, T, Clair, H C, Krutzsch, A A, Arestad, M E, Sobel, L A, Liotta, M L, Stracke
Publikováno v:
The Journal of biological chemistry. 269(48)
A human cDNA clone encoding autotaxin, a tumor cell motility-stimulating protein, reveals that this protein is an ecto/exo-enzyme with significant homology to the plasma cell membrane differentiation antigen PC-1. ATX is a 125-kDa glycoprotein, previ
Autor:
K A, Laderman, B R, Davis, H C, Krutzsch, M S, Lewis, Y V, Griko, P L, Privalov, C B, Anfinsen
Publikováno v:
The Journal of biological chemistry. 268(32)
The alpha-amylase from Pyrococcus furiosus, a hyperthermophilic archaebacterium, has been purified to homogeneity. The enzyme is a homodimer with a subunit molecular mass of 66 kDa. The isoelectric point is 4.3. The enzyme displays optimal activity,
Publikováno v:
The Journal of biological chemistry. 267(27)
Synthetic peptides derived from the type I repeats of human platelet thrombospondin containing a consensus sequence Trp-Ser-Xaa-Trp bind to heparin, promote cell adhesion, and inhibit heparin-dependent interactions of melanoma cells with extracellula