Zobrazeno 1 - 10
of 3 887
pro vyhledávání: '"H Busch"'
Autor:
Sander W Tas, Joep Killestein, Joost Raaphorst, Taco W Kuijpers, Alexandre E Voskuyl, Gertjan Wolbink, Theo Rispens, Anneke J van der Kooi, Anja Ten Brinke, Karina de Leeuw, Abraham Rutgers, Juan J Garcia-Vallejo, Frederike J Bemelman, YK Onno Teng, Phyllis I Spuls, Mark Löwenberg, Jelle de Wit, Diane van der Woude, Marcel W Bekkenk, Luuk Wieske, Esther Brusse, Laura Boekel, Filip Eftimov, Eileen W Stalman, Maurice Steenhuis, Sofie Keijzer, Olvi Cristianawati, Koos P J van Dam, Adriaan G Volkers, Annelie H Musters, Nicoline F Post, Angela L Bosma, Marc L Hilhorst, Yosta Vegting, Bo Broens, Barbara Horváth, Annabel M Ruiter, Matthias H Busch, Dirk Jan Hijnen, Niels J M Verstegen, Pieter A van Doorn, Jan JGM Verschuuren, Laura Y L Kummer, Ruth R Hagen, Christine Kreher, Lisan H Kuijper, Mariël C Duurland, Veronique A L Konijn, Carolien E van de Sandt, Laura Fernández Blanco, Amélie Bos, Charlotte Menage, Tineke Jorritsma, Jet van den Dijssel, Rivka de Jongh, Tom Ashhurst, Marit J van Gils, Mathieu Claireaux, Sija Marieke van Ham, Renée CF van Allaart, Adája E Baars, George Elias, Cécile ACM van Els, H Stephan Goedee, Geert RAM D’Haens, Papay BP Jallah, Elham S Mirfazeli, Jim BD Keijser, Lotte van Ouwerkerk, Pieter van Paassen, Agner R Parra Sanchez, W Ludo van der Pol, Corine RG Schreurs, R Bart Takkenberg, Koos AH Zwinderman
Publikováno v:
RMD Open, Vol 10, Iss 4 (2024)
Objectives Methotrexate (MTX) is one of the most commonly used medications to treat rheumatoid arthritis (RA). However, the effect of MTX treatment on cellular immune responses remains incompletely understood. This raises concerns about the vulnerabi
Externí odkaz:
https://doaj.org/article/afff65e4600e4deabe9d42545d2637c0
Autor:
Elisabeth Esser, Eva C. Schulte, Alexander Graf, Alexander Karollus, Nicholas H. Smith, Thomas Michler, Stefan Dvoretskii, Angel Angelov, Michael Sonnabend, Silke Peter, Christina Engesser, Aleksandar Radonic, Andrea Thürmer, Max von Kleist, Friedemann Gebhardt, Clarissa Prazeres da Costa, Dirk H. Busch, Maximilian Muenchhoff, Helmut Blum, Oliver T. Keppler, Julien Gagneur, Ulrike Protzer
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract The SARS-CoV-2 pandemic has highlighted the need to better define in-hospital transmissions, a need that extends to all other common infectious diseases encountered in clinical settings. To evaluate how whole viral genome sequencing can cont
Externí odkaz:
https://doaj.org/article/d2e44a1b69c64e72a9c65953950f2384
Autor:
Fawad Khan, Thomas R. Müller, Bahram Kasmapour, Mario Alberto Ynga-Durand, Britta Eiz-Vesper, Jens von Einem, Dirk H. Busch, Luka Cicin-Sain
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionHuman Cytomegalovirus (HCMV) is a betaherpesvirus that causes severe disease in immunocompromised transplant recipients. Immunotherapy with CD8 T cells specific for HCMV antigens presented on HLA class-I molecules is explored as strategy
Externí odkaz:
https://doaj.org/article/5383d64b68704ffa9711620b48d0c27e
Autor:
Kathrin Rothe, Tobias Bachfischer, Siranush Karapetyan, Alexander Hapfelmeier, Milena Wurst, Sabine Gleich, Karl Dichtl, Roland M. Schmid, Julian Triebelhorn, Laura Wagner, Johanna Erber, Florian Voit, Rainer Burgkart, Andreas Obermeier, Ulrich Seybold, Dirk H. Busch, Patrick C. Rämer, Christoph D. Spinner, Jochen Schneider
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 6 (2024)
Externí odkaz:
https://doaj.org/article/e0a27fbc60794d369a33d66bc60c102f
Autor:
Jacqueline Seigner, Charlotte U. Zajc, Sarah Dötsch, Caroline Eigner, Elisabeth Laurent, Dirk H. Busch, Manfred Lehner, Michael W. Traxlmayr
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract The majority of approved CAR T cell products are based on the FMC63-scFv directed against CD19. Surprisingly, although antigen binding affinity is a major determinant for CAR function, the affinity of the benchmark FMC63-scFv has not been un
Externí odkaz:
https://doaj.org/article/99196f542e2244e996021a41392220b3
Autor:
Simon P. Fraessle, Claudia Tschulik, Manuel Effenberger, Vlad Cletiu, Maria Gerget, Kilian Schober, Dirk H. Busch, Lothar Germeroth, Christian Stemberger, Mateusz P. Poltorak
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-7 (2023)
Abstract CAR T cell therapy is a rapidly growing area of oncological treatments having a potential of becoming standard care for multiple indications. Coincidently, CRISPR/Cas gene-editing technology is entering next-generation CAR T cell product man
Externí odkaz:
https://doaj.org/article/4cff20855bed40668525e3196d9e0810
Autor:
Mortimer Svec, Sarah Dötsch, Linda Warmuth, Manuel Trebo, Simon Fräßle, Stanley R. Riddell, Ulrich Jäger, Elvira D’Ippolito, Dirk H. Busch
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
Adoptive immunotherapy based on chimeric antigen receptor (CAR)-engineered T cells has exhibited impressive clinical efficacy in treating B-cell malignancies. However, the potency of CAR-T cells carriethe potential for significant on-target/off-tumor
Externí odkaz:
https://doaj.org/article/9aee9b6ee6394d788168edede811263c
Autor:
Benno Lickefett, Lulu Chu, Valentin Ortiz-Maldonado, Linda Warmuth, Pere Barba, Matteo Doglio, David Henderson, Michael Hudecek, Andreas Kremer, Janet Markman, Magdalena Nauerth, Helene Negre, Carmen Sanges, Philipp B. Staber, Rebecca Tanzi, Julio Delgado, Dirk H. Busch, Jürgen Kuball, Maik Luu, Ulrich Jäger
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Lymphodepletion (LD) or conditioning is an essential step in the application of currently used autologous and allogeneic chimeric antigen receptor T-cell (CAR-T) therapies as it maximizes engraftment, efficacy and long-term survival of CAR-T. Its mai
Externí odkaz:
https://doaj.org/article/867d97eccd50488c8737f46f9637a5f0
Autor:
Kathrin Rothe, Tobias Bachfischer, Siranush Karapetyan, Alexander Hapfelmeier, Milena Wurst, Sabine Gleich, Karl Dichtl, Roland M. Schmid, Julian Triebelhorn, Laura Wagner, Johanna Erber, Florian Voit, Rainer Burgkart, Andreas Obermeier, Ulrich Seibold, Dirk H. Busch, Patrick C. Rämer, Christoph D. Spinner, Jochen Schneider
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 6 (2023)
ABSTRACT To assess the long-term survival of patients with enterococcal bloodstream infections (BSI), encompassing various species and resistance patterns compared to Escherichia coli (E. coli) BSI. Between 2010–2019, 3,290 enterococcal and 3,415 E
Externí odkaz:
https://doaj.org/article/bc7d4dcab81e413ba1f1e5a3a05018ec
Autor:
Koos P. J. van Dam, Adriaan G. Volkers, Luuk Wieske, Eileen W. Stalman, Laura Y. L. Kummer, Zoé L. E. van Kempen, Joep Killestein, Sander W. Tas, Laura Boekel, Gerrit J. Wolbink, Anneke J. van der Kooi, Joost Raaphorst, R. Bart Takkenberg, Geert R. A. M. D’Haens, Phyllis I. Spuls, Marcel W. Bekkenk, Annelie H. Musters, Nicoline F. Post, Angela L. Bosma, Marc L. Hilhorst, Yosta Vegting, Frederike J. Bemelman, Alexandre E. Voskuyl, Bo Broens, Agner Parra Sanchez, Cécile A. C. M. van Els, Jelle de Wit, Abraham Rutgers, Karina de Leeuw, Barbara Horváth, Jan J. G. M. Verschuuren, Annabel M. Ruiter, Lotte van Ouwerkerk, Diane van der Woude, Renée C. F. Allaart, Y. K. Onno Teng, Pieter van Paassen, Matthias H. Busch, Papay B. P. Jallah, Esther Brusse, Pieter A. van Doorn, Adája E. Baars, Dirk Jan Hijnen, Corine R. G. Schreurs, W. Ludo van der Pol, H. Stephan Goedee, Maurice Steenhuis, Sofie Keijzer, Jim B. D. Keijser, Olvi Cristianawati, Anja ten Brinke, Niels J. M. Verstegen, S. Marieke van Ham, Theo Rispens, Taco W. Kuijpers, Mark Löwenberg, Filip Eftimov, on behalf of the T2B! Immunity against SARS-CoV-2 study group
Publikováno v:
BMC Infectious Diseases, Vol 23, Iss 1, Pp 1-11 (2023)
Abstract Background Patients with immune-mediated inflammatory diseases (IMIDs) on immunosuppressants (ISPs) may have impaired long-term humoral immune responses and increased disease activity after SARS-CoV-2 infection. We aimed to investigate long-
Externí odkaz:
https://doaj.org/article/8a6e2bdaa5404154a54ecf8fcb54843c