Zobrazeno 1 - 10
of 1 475
pro vyhledávání: '"H Blackburn"'
Publikováno v:
AIP Advances, Vol 14, Iss 2, Pp 025035-025035-5 (2024)
Single-crystalline Ga1−xMnxS is a quasi-two-dimensional system that exhibits an anomalous spin-glass transition temperature compared with the other well-known spin-glass systems. In contrast to the other known spin-glasses that all have three-dimen
Externí odkaz:
https://doaj.org/article/1831b114502e4147978ac777c5ff3278
Autor:
Ryan Rampersaud, Gwyneth W. Y. Wu, Victor I. Reus, Jue Lin, Elizabeth H. Blackburn, Elissa S. Epel, Christina M. Hough, Synthia H. Mellon, Owen M. Wolkowitz
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Telomere length (TL) is a marker of biological aging, and shorter telomeres have been associated with several medical and psychiatric disorders, including cardiometabolic dysregulation and Major Depressive Disorder (MDD). In addition, studie
Externí odkaz:
https://doaj.org/article/eced414471ba40eebb992e5b4b44aa9b
Autor:
Tracy T. Chow, Xiaoyu Shi, Jen-Hsuan Wei, Juan Guan, Guido Stadler, Bo Huang, Elizabeth H. Blackburn
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Chromatin dynamics is thought to play an important role in the maintenance of telomeres, yet how has remained poorly understood. Here the authors locally enrich heterochromatin protein 1α (HP1α) at human telomeres to provide insights into the cross
Externí odkaz:
https://doaj.org/article/fba23e2f45694006b4935b2e453fa373
Human telomerase reverse transcriptase (hTERT; the catalytic protein subunit of telomerase) is subjected to numerous alternative splicing events, but the regulation and function of these splice variants is obscure. Full-length hTERT includes conserve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5bc043ec63b87a2d2c2030f124da7ee
https://doi.org/10.1158/0008-5472.c.6505496
https://doi.org/10.1158/0008-5472.c.6505496
PDF file - 516K, T1. Breast cell lines used in this study. T2. Summary of results for 45 breast cancer cell lines and 5 non-malignant cell lines. T3. Correlation of hTERT α/β splice variants, telomerase activity, telomere length and hTR in 50 breas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6cdc16655514655afd699a2a0e29097
https://doi.org/10.1158/0008-5472.22400087.v1
https://doi.org/10.1158/0008-5472.22400087.v1
Autor:
Elizabeth H. Blackburn, Amir Goldkorn
The telomerase ribonucleoprotein is a promising target for cancer therapy, as it is highly active in many human malignancies. A novel telomerase targeting approach combines short interfering RNA (siRNA) knockdown of endogenous human telomerase RNA (h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22266a3d2fc96aabc39cfb4ca8604d9e
https://doi.org/10.1158/0008-5472.c.6494036
https://doi.org/10.1158/0008-5472.c.6494036
Autor:
Elizabeth H. Blackburn, Gerald R. Cunha, Yun Kit Hom, Inna L. Botchkina, Annemarie A. Donjacour, Jonathan E. Rosenberg, Shang Li
In human cancers, telomeres are commonly maintained by elevated levels of the ribonucleoprotein enzyme telomerase, which contains an intrinsic templating RNA moiety (human telomerase RNA; hTER) and the core protein (human telomerase reverse transcrip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12f2421a48c45ad38ba473d3f839c508
https://doi.org/10.1158/0008-5472.c.6493700
https://doi.org/10.1158/0008-5472.c.6493700
PDF file - 236K, S1. hTERT and SRSF3 splice variant enrichment after cycloheximide treatment. S2. Total SRSF3 and hTERT splice variant mRNA abundance in ribosome-containing fractions. S3. Unaltered microscopy image shown in Figure 3. S4. SRSF11 and h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c033022129edae952fe1c9bc147fe5d3
https://doi.org/10.1158/0008-5472.22400093.v1
https://doi.org/10.1158/0008-5472.22400093.v1
Autor:
Elizabeth H. Blackburn, Amir Goldkorn
Supplementary Figures 1-5 from Assembly of Mutant-Template Telomerase RNA into Catalytically Active Telomerase Ribonucleoprotein That Can Act on Telomeres Is Required for Apoptosis and Cell Cycle Arrest in Human Cancer Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ae466e515185456b8c0a04b10eb6897
https://doi.org/10.1158/0008-5472.22364150
https://doi.org/10.1158/0008-5472.22364150