Zobrazeno 1 - 5
of 5
pro vyhledávání: '"H Begum Akman"'
Autor:
Catherine Lindon, Rogier Schepers, Philippe Giron, Jacques De Greve, H Begum Akman, M Angeles Ceregido, Luis C Ramos Paez, Esther La Monaca, Carl De Trez, Mara Esposito, Olivier Coux, Gustavo J. Gutierrez
Publikováno v:
Oncogene
Oncogene, Nature Publishing Group, 2020, 39 (37), pp.6009-6023. ⟨10.1038/s41388-020-01396-8⟩
Oncogene, Nature Publishing Group, 2020, 39 (37), pp.6009-6023. ⟨10.1038/s41388-020-01396-8⟩
Aurora B kinase plays essential roles in mitosis. Its protein levels increase before the onset of mitosis and sharply decrease during mitosis exit. The latter decrease is due to a balance between the actions of the E3 ubiquitin ligase anaphase-promot
Autor:
Ahmed, Abdelbaki, Camilla, Ascanelli, Cynthia N, Okoye, H Begum, Akman, Giacomo, Janson, Mingwei, Min, Chiara, Marcozzi, Anja, Hagting, Rhys, Grant, Maria, De Luca, Italia Anna, Asteriti, Giulia, Guarguaglini, Alessandro, Paiardini, Catherine, Lindon
Publikováno v:
Life science alliance. 6(2)
Mitotic kinase Aurora A (AURKA) diverges from other kinases in its multiple active conformations that may explain its interphase roles and the limited efficacy of drugs targeting the kinase pocket. Regulation of AURKA activity by the cell is critical
Autor:
Ahmed Abdelbaki, Camilla Ascanelli, Cynthia N Okoye, H Begum Akman, Giacomo Janson, Mingwei Min, Chiara Marcozzi, Anja Hagting, Rhys Grant, Maria De Luca, Italia Anna Asteriti, Giulia Guarguaglini, Alessandro Paiardini, Catherine Lindon
Publikováno v:
Life Science Alliance. 6:e202201372
Mitotic kinase Aurora A (AURKA) diverges from other kinases in its multiple active conformations that may explain its interphase roles and the limited efficacy of drugs targeting the kinase pocket. Regulation of AURKA activity by the cell is critical
Autor:
H Begum Akman, Ahmed Abdelbaki, Giulia Guarguaglini, Olivier Gavet, Catherine Lindon, Marion Poteau, Rhys Grant
Publikováno v:
Journal of Cell Science
article-version (VoR) Version of Record
Journal of cell science (Online) (2020).
info:cnr-pdr/source/autori:Ahmed Abdelbaki, H. Begum Akman, Marion Poteau, Rhys Grant, Olivier Gavet, Giulia Guarguaglini, Catherine Lindon/titolo:AURKA destruction is decoupled from its activity at mitotic exit but essential to suppress interphase activity/doi:/rivista:Journal of cell science (Online)/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume
article-version (VoR) Version of Record
Journal of cell science (Online) (2020).
info:cnr-pdr/source/autori:Ahmed Abdelbaki, H. Begum Akman, Marion Poteau, Rhys Grant, Olivier Gavet, Giulia Guarguaglini, Catherine Lindon/titolo:AURKA destruction is decoupled from its activity at mitotic exit but essential to suppress interphase activity/doi:/rivista:Journal of cell science (Online)/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume
Activity of AURKA is controlled through multiple mechanisms including phosphorylation, ubiquitin-mediated degradation and allosteric interaction with TPX2. Activity peaks at mitosis, before AURKA is degraded during and after mitotic exit in a process
Autor:
Marion Poteau, Rhys Grant, H Begum Akman, Ahmed Abdelbaki, Giulia Guarguaglini, Catherine Lindon, Olivier Gavet
Activity of AURKA is controlled through multiple mechanisms including phosphorylation, ubiquitin-mediated degradation, and allosteric interaction with TPX2. Activity peaks at mitosis before AURKA is degraded during mitotic exit in a process strictly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9a8f532a44985ebe94e25d239971cf5
https://doi.org/10.1101/850917
https://doi.org/10.1101/850917