BayFlux: A Bayesian method to quantify metabolic Fluxes and their uncertainty at the genome scale.

Autor: Tyler W H Backman, Christina Schenk, Tijana Radivojevic, David Ando, Jahnavi Singh, Jeffrey J Czajka, Zak Costello, Jay D Keasling, Yinjie Tang, Elena Akhmatskaya, Hector Garcia Martin

Publikováno v: PLoS Computational Biology, Vol 19, Iss 11, p e1011111 (2023)

Metabolic fluxes, the number of metabolites traversing each biochemical reaction in a cell per unit time, are crucial for assessing and understanding cell function. 13C Metabolic Flux Analysis (13C MFA) is considered to be the gold standard for measu

Externí odkaz: https://doaj.org/article/23460991878e4f2daf19048745ca008c

Previous pre‐eclampsia, gestational diabetes mellitus and the risk of cardiovascular disease: A nested case–control study in Sweden

Autor: K. Hildén, A. Magnuson, S. Montgomery, E. Schwarcz, U. Hanson, D. Simmons, H. Backman

Publikováno v: BJOG: An International Journal of Obstetrics & Gynaecology.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1828598671205a76c990e0ccd01565d3
https://doi.org/10.1111/1471-0528.17454

ClusterCAD 2.0: an updated computational platform for chimeric type I polyketide synthase and nonribosomal peptide synthetase design

Autor: Xavier B Tao, Sarah LaFrance, Yifei Xing, Alberto A Nava, Hector Garcia Martin, Jay D Keasling, Tyler W H Backman

Publikováno v: Tao, X B, LaFrance, S, Xing, Y, Nava, A A, Martin, H G, Keasling, J D & Backman, T W H 2023, ' ClusterCAD 2.0: an updated computational platform for chimeric type I polyketide synthase and nonribosomal peptide synthetase design ', Nucleic Acids Research, vol. 51, no. D1, gkac1075 . https://doi.org/10.1093/nar/gkac1075

Megasynthase enzymes such as type I modular polyketide synthases (PKSs) and nonribosomal peptide synthetases (NRPSs) play a central role in microbial chemical warfare because they can evolve rapidly by shuffling parts (catalytic domains) to produce n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78520736423a4a9b83cf5370c089ab22
https://pubmed.ncbi.nlm.nih.gov/36416273

Among both men and women with COPD ever-smokers have higher disease burden and worse prognosis than never-smokers

Autor: A Lindberg, E Szakacs, C Stridsman, S Sawalha, U Nilsson, L Hedman, E Rönmark, H Backman

Publikováno v: 06.01 - Epidemiology.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2807e5513cd6d68d9775e8240c508fb4
https://doi.org/10.1183/13993003.congress-2022.1060

BMI increase – A determinant of FEV1 decline for overweight and obese adults with asthma

Autor: N Bermudez Baron, H Kankaanranta, L Hedman, M Andersson, C Stridsman, A Lindberg, E Rönmark, H Backman

Publikováno v: 06.01 - Epidemiology.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2ec7005696e4dfc76a1228339dd4aa24
https://doi.org/10.1183/13993003.congress-2022.640