Zobrazeno 1 - 10 of 943 pro vyhledávání: '"H B, Huang"'
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Akademický článek
p90RSK pathway inhibition synergizes with cisplatin in TMEM16A overexpressing head and neck cancer
Autor: Abdulkader Yassin-Kassab, Suman Chatterjee, Nayel Khan, Nathaniel Wang, Vlad C. Sandulache, Eric H-B. Huang, Timothy F. Burns, Umamaheswar Duvvuri
Publikováno v: BMC Cancer, Vol 24, Iss 1, Pp 1-12 (2024)
Abstract Head and neck squamous cell carcinoma (HNSCC) constitutes one of the most common types of human cancers and often metastasizes to lymph nodes. Platinum-based chemotherapeutic drugs are commonly used for treatment of a wide range of cancers,
Externí odkaz: https://doaj.org/article/51729d77fd4f4e76a3435a6037e5e191
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2
Akademický článek
let-7i inhibits proliferation and migration of bladder cancer cells by targeting HMGA1
Autor: M-M Qin, X. Chai, H-B Huang, G. Feng, X-N Li, J. Zhang, R. Zheng, X-C Liu, C. Pu
Publikováno v: BMC Urology, Vol 19, Iss 1, Pp 1-8 (2019)
Abstract Background Let-7 is one of the earliest discovered microRNAs(miRNAs) and has been reported to be down-regulated in multiple malignant tumors. The effects and molecular mechanisms of let-7i in bladder cancer are still unclear. This study was
Externí odkaz: https://doaj.org/article/c04b598312ee46779dc967a528e0f391
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4
Supplementary Figures S1-S13 from Reactivation of the p90RSK–CDC25C Pathway Leads to Bypass of the Ganetespib-Induced G2–M Arrest and Mediates Acquired Resistance to Ganetespib in KRAS-Mutant NSCLC
Autor: Timothy F. Burns, Ian Christie, Eric H.-B. Huang, Suman Chatterjee
Supplementary Figure S1: Acquired resistance to ganetespib in KRAS mutant NSCLC cell line, H460, leads to loss of ganetespib induced G2/M arrest; Supplementary Figure S2: p90RSK overexpression leads to bypass of ganetespib induced G2/M arrest in an i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f88af85c86caadc062c14252217decd
https://doi.org/10.1158/1535-7163.22507662.v1
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7
Data from Acquired Resistance to the Hsp90 Inhibitor, Ganetespib, in KRAS-Mutant NSCLC Is Mediated via Reactivation of the ERK–p90RSK–mTOR Signaling Network
Autor: Timothy F. Burns, Brenda F. Kurland, Ian Christie, Eric H.-B. Huang, Suman Chatterjee
Approximately 25% of non–small cell lung cancer (NSCLC) patients have KRAS mutations, and no effective therapeutic strategy exists for these patients. The use of Hsp90 inhibitors in KRAS-mutant NSCLC appeared to be a promising approach, as these in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::708e0c467c76e5ff6c4e4428621ae616
https://doi.org/10.1158/1535-7163.c.6539424.v1
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Data from Reactivation of the p90RSK–CDC25C Pathway Leads to Bypass of the Ganetespib-Induced G2–M Arrest and Mediates Acquired Resistance to Ganetespib in KRAS-Mutant NSCLC
Autor: Timothy F. Burns, Ian Christie, Eric H.-B. Huang, Suman Chatterjee
A subset of non–small cell lung cancers (NSCLC) are dependent upon oncogenic driver mutations, including the most frequently observed driver mutant KRAS, which is associated with a poor prognosis. As direct RAS targeting in the clinic has been unsu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c78c4d0af2b61fe4459b4378477cc644
https://doi.org/10.1158/1535-7163.c.6538755.v1
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