Zobrazeno 1 - 5
of 5
pro vyhledávání: '"H B, Cottam"'
Publikováno v:
Blood. 96(10)
Adenine deoxynucleosides induce apoptosis in quiescent lymphocytes and are thus useful drugs for the treatment of indolent lymphoproliferative diseases. To explain why deoxyadenosine and its analogs are toxic to a cell that is not undergoing replicat
Autor:
G R Revankar, R A Burger, B. S. Sharma, Donald F. Smee, K Ramasamy, Hassan A. Alaghamandan, J Gilbert, A. Jin, H B Cottam, W. B. Jolley
Publikováno v:
Antimicrobial agents and chemotherapy. 35(1)
The nucleotide analog 7-deazaguanosine has not previously been reported to possess biological (antiviral or antitumor) properties in cell culture or in vivo. Up to 10(5) U of interferon per ml was detected in mouse sera 1 to 4 h following oral (200-m
Publikováno v:
Journal of biological response modifiers. 9(1)
A novel thiazolopyrimidine nucleoside, 5-amino-3-beta-D-ribofuranosylthiazolo[4,5-d]pyrimidine-2,7(3H,6H) -dione (7-thia-8-oxoguanosine), was evaluated for antiviral activity in rodent models, and at 50-200 mg/kg prevented death in mice inoculated in
Broad-spectrum in vivo antiviral activity of 7-thia-8-oxoguanosine, a novel immunopotentiating agent
Autor:
W. B. Jolley, B. S. Sharma, H B Cottam, Hassan A. Alaghamandan, Roland K. Robins, Donald F. Smee
Publikováno v:
Antimicrobial agents and chemotherapy. 33(9)
A novel immunopotentiating agent, 5-amino-3-beta-D-ribofuranosylthiazolo [4,5-d]pyrimidine-2,7(3H,6H)-dione (7-thia-8-oxoguanosine), lacks virus-inhibitory properties in vitro but induces interferon and potentiates immune functions, such as natural k