Výsledky vyhledávání - "H A Zurcher-Neely"

Degradation of growth hormone releasing factor analogs in neutral aqueous solution is related to deamidation of asparagine residues

Autor: L. F. Krabill, R. M. Hillman, A. K. Ichhpurani, H A Zurcher-Neely, Alan R. Friedman, David M. Guido, R. A. Martin, D. M. Brown

Publikováno v: International Journal of Peptide and Protein Research. 37:14-20

The incubation of a solution of the human growth hormone releasing factor analog, [Leu27] hGRF(1-32)NH2 at pH 7.4 and 37 degrees, resulted in extensive degradation of the sample. The major degradation products were identified as the peptides [beta-As

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ade37036b2d65367d06b89df069c4206
https://doi.org/10.1111/j.1399-3011.1991.tb00727.x

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Dipeptidyl peptidase IV (DPP-IV) from pig kidney cleaves analogs of bovine growth hormone-releasing factor (bGRF) modified at position 2 with Ser, Thr or Val. Extended DPP-IV substrate specificity?

Autor: David M. Guido, Diane L. Cleary, Roger A. Martin, H A Zurcher-Neely, Teresa M. Kubiak

Publikováno v: Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1164:252-260

The literature reported DPP-IV substrate specificity includes oligopeptides with a penultimate Pro, Hyp or Ala residue. Bovine GRF is a substrate for DPP-IV and is rapidly degraded by the enzyme via removal of its N-terminal Tyr-Ala. Incubation of se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6459da09b75d5353e0ff7b011d1f299
https://doi.org/10.1016/0167-4838(93)90256-q

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Purification and characterization of heterodimeric human immunodeficiency virus type 1 (HIV-1) reverse transcriptase produced by in vitro processing of p66 with recombinant HIV-1 protease

Autor: F M Eckenrode, A G Tomasselli, Robert L. Heinrikson, Martin R. Deibel, H.M. Einspahr, H. A. Zurcher-Neely, J. O. Hui, A F Vosters, David B. Evans, Debasish Chattopadhyay

Publikováno v: Journal of Biological Chemistry. 267:14227-14232

Active recombinant reverse transcriptase (RT) of human immunodeficiency virus type 1 (HIV-1) with an amino-terminal extension containing a hexa-histidine sequence has been prepared in milligram quantities in a pure heterodimeric (p66/p51) form by coo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b0ee306d622c5acfbd5880e3f966cf8f
https://doi.org/10.1016/s0021-9258(19)49701-9

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The Hsp56 component of steroid receptor complexes binds to immobilized FK506 and shows homology to FKBP-12 and FKBP-13

Autor: H A Zurcher-Neely, V A Ruff, R A Johnson, Anthony W. Yem, Martin R. Deibel, A G Tomasselli, Robert L. Heinrikson

Publikováno v: Journal of Biological Chemistry. 267:2868-2871

Extracts from human Jurkat cells or from calf thymus contain a 60-kDa protein that is bound to immobilized FK506. As expected, the NH2-terminal sequences of the 60-kDa protein from these two species were found to be nearly the same. We were surprised

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::05a20e8156deacd8f2a13dffbd2a8358
https://doi.org/10.1016/s0021-9258(19)50664-0

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Actin, troponin C, Alzheimer amyloid precursor protein and pro-interleukin 1 beta as substrates of the protease from human immunodeficiency virus

Autor: Barry D. Greenberg, Robert L. Heinrikson, Martin R. Deibel, J G Chosay, A G Tomasselli, Anthony W. Yem, L D Adams, J. O. Hui, H A Zurcher-Neely, David E. Lowery

Publikováno v: Journal of Biological Chemistry. 266:14548-14553

We show here for the first time that actin, troponin C, Alzheimer amyloid precursor protein (AAP), and pro-interleukin 1 beta (pro-IL-1 beta), are substrates of the protease encoded by the human immunodeficiency virus (HIV) type-1. As has been seen i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::29ff572f783491d2f651487e0e7699be
https://doi.org/10.1016/s0021-9258(18)98721-1

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Purification and characterization of interleukin 1 receptor level antagonist proteins from THP-1 cells

Autor: Scott E. Truesdell, Robert L. Heinrikson, I M Reardon, Michael J. Bienkowski, Alice L. Laborde, J. A. Shelly, Ann E. Berger, J G Chosay, Thomas E. Eessalu, H A Zurcher-Neely

Publikováno v: Journal of Biological Chemistry. 265:14505-14511

Culture medium conditioned by phorbol 12-myristate 13-acetate-differentiated THP-1 cells contained interleukin 1 (IL-1) antagonist activity as measured by inhibition of both IL-1 beta binding to receptors on YT cells and inhibition of IL-1/phytohemag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::11d8307695477d3decbcddad94e5dc19
https://doi.org/10.1016/s0021-9258(18)77331-6

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Amino acid sequence and characterization of a protein inhibitor of protein kinase C

Autor: N M Mozier, Robert L. Heinrikson, J R McDonald, H A Zurcher-Neely, E D Fraser, W D McCubbin, James D. Pearson, W R Mathews, Daryll B. DeWald, M A Morris

Publikováno v: Journal of Biological Chemistry. 265:4583-4591

The complete primary structure has been determined for an inhibitor protein of protein kinase C. The bovine brain-derived inhibitor has a pI of 6 and its N-terminal alanine residue is blocked by acetylation. Fragments obtained by chemical and enzymat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b549259e4d01fe09a2c7e7f51f403d8b
https://doi.org/10.1016/s0021-9258(19)39603-6

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Purification and characterization of heterodimeric human immunodeficiency virus type 1 (HIV-1) reverse transcriptase produced by in vitro processing of p66 with recombinant HIV-1 protease

Autor: D, Chattopadhyay, D B, Evans, M R, Deibel, A F, Vosters, F M, Eckenrode, H M, Einspahr, J O, Hui, A G, Tomasselli, H A, Zurcher-Neely, R L, Heinrikson

Publikováno v: The Journal of biological chemistry. 267(20)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cff03eec8d239f3c01cac78b4fbb0e91
https://pubmed.ncbi.nlm.nih.gov/1378437

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Chemical synthesis of a biotinylated derivative of the simian immunodeficiency virus protease. Purification by avidin affinity chromatography and autocatalytic activation

Autor: A G, Tomasselli, C A, Bannow, M R, Deibel, J O, Hui, H A, Zurcher-Neely, I M, Reardon, C W, Smith, R L, Heinrikson

Publikováno v: The Journal of biological chemistry. 267(15)

The protease from simian immunodeficiency virus (SIV) was chemically synthesized by automated solid-phase technology as an NH2-terminally extended derivative, capped with biotin. Biotin-linker-(SIV protease (1-99)): the linker segment, Gly-Gly-Asp-Ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::88a439aa8127f35ff8fb404900a00268
https://pubmed.ncbi.nlm.nih.gov/1587812

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