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Induction of glutathione S-transferase pi as a bioassay for the evaluation of potency of inhibitors of benzo(a)pyrene-induced cancer in a murine model

Autor: X, Hu, P J, Benson, S K, Srivastava, H, Xia, R J, Bleicher, H A, Zaren, S, Awasthi, Y C, Awasthi, S V, Singh

Publikováno v: International journal of cancer. 73(6)

There is a growing need for short-term and cost-effective bioassay to assess the efficacy of potential chemo-preventive agents. We report that the induction of glutathione (GSH) S-transferase pi (mGSTP1-1) by a chemo-preventive agent can be used as a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c5e2ad547c95849cffd944830c03ca23
https://pubmed.ncbi.nlm.nih.gov/9399673

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Mechanism of increased sensitivity to etoposide in a mitomycin C-resistant human bladder cancer cell line

Autor: H, Xia, R J, Bleicher, V, Gupta, H A, Zaren, S V, Singh

Publikováno v: International journal of cancer. 70(5)

The mechanism of increased sensitivity to etoposide (VP-16) in a human bladder cancer cell line (J82/MMC-2), which is9-fold more resistant to mitomycin C (MMC) compared with parental cells (J82/WT), was investigated. Colony formation assays, followin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3f0d88a088854b43256277860142341f
https://pubmed.ncbi.nlm.nih.gov/9052763

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Lack of a role of glutathione in cellular nonenzymatic activation of BMS-181174, a novel analogue of mitomycin C

Autor: H, Xia, T, Pinto, X, Hu, P J, Benson, H A, Zaren, V, Gupta, S, Singh

Publikováno v: Cancer research. 56(15)

Recent studies, using a cell-free system, have suggested that thiol-dependent nonenzymatic bioactivation may be responsible for the superior antitumor activity of the mitomycin C analogue BMS-181174 [N-7-[2-(4-nitrophenyldithio)ethyl]mitomycin C] whe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ee7071da5b1df97d4f4c1a92c952ab74
https://pubmed.ncbi.nlm.nih.gov/8758917

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Biochemical characterization of a mitomycin C-resistant human bladder cancer cell line

Autor: S V, Singh, D, Scalamogna, H, Xia, S, O'Toole, D, Roy, E O, Emerson, V, Gupta, H A, Zaren

Publikováno v: International journal of cancer. 65(6)

This study describes characteristics of a mitomycin C (MMC)-resistant human bladder cancer cell line, J82/MMC-2, which was established by repeated in vitro exposures of a 6-fold MMC-resistant variant (J82/MMC) to 18 nM MMC. A 9.6-fold higher concentr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3b6a2e834729959e31f0ce4f3e49e2f9
https://pubmed.ncbi.nlm.nih.gov/8631603

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Detection of preoperatively unrecognized multiple pancreatic pseudocysts by intraoperative ultrasonography. Report of two cases

Autor: T, Kurohiji, B, Sigel, J, Machi, H A, Zaren, C Z, Hayward, J, Sariego, L, Loiacono, I, Kodama, F D, Ferdinand

Publikováno v: The American surgeon. 57(10)

During two pancreatic operations, intraoperative ultrasonography detected multiple pancreatic pseudocysts that were unrecognized preoperatively. In each operation, a single pseudocyst was detected by preoperative ultrasonography, computed tomography,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::52d9c0106cca0c9515460efaf7ec9a31
https://pubmed.ncbi.nlm.nih.gov/1928985

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