Výsledky vyhledávání - "H A, Gelbard"

Neurotrophins prevent HIV Tat-induced neuronal apoptosis via a nuclear factor-kappaB (NF-kappaB)-dependent mechanism

Autor: S H, Ramirez, J F, Sanchez, C A, Dimitri, H A, Gelbard, S, Dewhurst, S B, Maggirwar

Publikováno v: Journal of neurochemistry. 78(4)

HIV-1 associated dementia is thought to be caused by neuronal damage and death in response to the production of soluble neurotoxic factors by virally infected mononuclear phagocytes. These neurotoxins include HIV-1 Tat. The ability of neurotrophins t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f3512994daf2b982ddfc1974eb2eb1e4
https://pubmed.ncbi.nlm.nih.gov/11520908

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Activation of glycogen synthase kinase 3 beta (GSK-3beta) by platelet activating factor mediates migration and cell death in cerebellar granule neurons

Autor: N, Tong, J F, Sanchez, S B, Maggirwar, S H, Ramirez, H, Guo, S, Dewhurst, H A, Gelbard

Publikováno v: The European journal of neuroscience. 13(10)

Children with vertically acquired HIV-1 can present with a rapidly progressive encephalopathy and neuronal apoptosis in the first 12-18 months of life. Furthermore, abnormal prenatal platelet activating factor (PAF) signalling may result in lissencep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4a8ca61afdad6b869143be986bca9cf3
https://pubmed.ncbi.nlm.nih.gov/11403684

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Release of the neuronal glycoprotein ICAM-5 in serum after hypoxic-ischemic injury

Autor: H, Guo, N, Tong, T, Turner, L G, Epstein, M P, McDermott, P, Kilgannon, H A, Gelbard

Publikováno v: Annals of neurology. 48(4)

Intercellular adhesion molecule (ICAM)-5 (telencephalin) is unique among the ICAMs, because it is only expressed in somatodendritic membranes of telencephalic neurons. To investigate the fate of ICAM-5 during focal brain injury, we induced hypoxia-is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::21e5b89d1171dd44f26e5a1e5d658269
https://pubmed.ncbi.nlm.nih.gov/11026442

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Platelet-activating factor receptor activation. An initiator step in HIV-1 neuropathogenesis

Autor: S W, Perry, J A, Hamilton, L W, Tjoelker, G, Dbaibo, K A, Dzenko, L G, Epstein, Y, Hannun, J S, Whittaker, S, Dewhurst, H A, Gelbard

Publikováno v: The Journal of biological chemistry. 273(28)

Human immunodeficiency virus type 1 (HIV-1) infection of the central nervous system results in neuronal apoptosis. Activated HIV-1-infected monocytes secrete high levels of the proinflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) and the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6ca0c2314a49c9c7274b3b82352bf249
https://pubmed.ncbi.nlm.nih.gov/9651362

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Expression of pro- and anti-apoptosis gene products in brains from paediatric patients with HIV-1 encephalitis

Autor: S, Krajewski, H J, James, J, Ross, B M, Blumberg, L G, Epstein, H E, Gendelman, S, Gummuluru, S, Dewhurst, L R, Sharer, J C, Reed, H A, Gelbard

Publikováno v: Neuropathology and applied neurobiology. 23(3)

We have previously demonstrated the presence of DNA fragmentation in neurons, macrophages and microglia consistent with apoptosis, but not in reactive astrocytes in brain tissue from paediatric patients with HIV-1 encephalitis (HIVE). To further unde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::501f9ea3547a6c5c1e3519b915846182
https://pubmed.ncbi.nlm.nih.gov/9223134

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Tumor necrosis factor alpha inhibits glutamate uptake by primary human astrocytes. Implications for pathogenesis of HIV-1 dementia

Autor: S M, Fine, R A, Angel, S W, Perry, L G, Epstein, J D, Rothstein, S, Dewhurst, H A, Gelbard

Publikováno v: The Journal of biological chemistry. 271(26)

Human immunodeficiency virus (HIV) infection is commonly associated with neurological disease that occurs in the apparent absence of extensive infection of brain cells by HIV, suggesting that indirect mechanisms account for neuropathogenesis in the C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1f66c84ed2faa557e5341cb3c71066c1
https://pubmed.ncbi.nlm.nih.gov/8663435

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In situ amplification and detection of HIV-1 DNA in fixed pediatric AIDS brain tissue

Autor: L R, Sharer, Y, Saito, A, Da Cunha, P C, Ung, H A, Gelbard, L G, Epstein, B M, Blumberg

Publikováno v: Human pathology. 27(6)

To examine whether latent infection by HIV-1 occurs in the central nervous system, we optimized a procedure for amplification and detection of HIV-1 DNA in situ, in formalin-fixed brain tissue from a child with severe HIV-1-associated progressive enc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::689fe55406e2de048ce5e278e5f24f0e
https://pubmed.ncbi.nlm.nih.gov/8666375

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Activation of nuclear factor kappa B in brains from children with HIV-1 encephalitis

Autor: S C, Dollard, H J, James, L R, Sharer, L G, Epstein, H A, Gelbard, S, Dewhurst

Publikováno v: Neuropathology and applied neurobiology. 21(6)

Human immunodeficiency virus type 1 (HIV-1) infection of the central nervous system is associated with decreased neuronal density in discrete areas of the brain. Neuronal loss may occur via apoptosis, initiated by soluble neurotoxic factors secreted

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::72e22bc1d84e850aaeb40033617faa2d
https://pubmed.ncbi.nlm.nih.gov/8745241

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