Pharmacodynamic genome-wide association study identifies new responsive loci for glucocorticoid intervention in asthma

Autor: Y Wang, C Tong, Z Wang, D Mauger, K G Tantisira, E Israel, S J Szefler, V M Chinchilli, H A Boushey, S C Lazarus, R F Lemanske, R Wu

Publikováno v: Wang, Y; Tong, C; Wang, Z; Wang, Z; Mauger, D; Tantisira, KG; et al.(2015). Pharmacodynamic genome-wide association study identifies new responsive loci for glucocorticoid intervention in asthma. Pharmacogenomics Journal. doi: 10.1038/tpj.2014.83. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/44r1f8tr
The pharmacogenomics journal, vol 15, iss 5

© 2015 Macmillan Publishers Limited Asthma is a chronic lung disease that has a high prevalence. The therapeutic intervention of this disease can be made more effective if genetic variability in patients’ response to medications is implemented. Ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::113b0c50a5272709d37d0e5c30328db5
https://europepmc.org/articles/PMC6156797/

Inhaled corticosteroid reduction and elimination in patients with persistent asthma receiving salmeterol: a randomized controlled trial

Autor: R F, Lemanske, C A, Sorkness, E A, Mauger, S C, Lazarus, H A, Boushey, J V, Fahy, J M, Drazen, V M, Chinchilli, T, Craig, J E, Fish, J G, Ford, E, Israel, M, Kraft, R J, Martin, S A, Nachman, S P, Peters, J D, Spahn, S J, Szefler

Publikováno v: JAMA. 285(20)

Inhaled long-acting beta(2)-agonists improve asthma control when added to inhaled corticosteroid (ICS) therapy.To determine whether ICS therapy can be reduced or eliminated in patients with persistent asthma after adding a long-acting beta(2)-agonist

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9b8c95dcb18989d7189179f3b7b52c69
https://pubmed.ncbi.nlm.nih.gov/11829556

Effect of polymorphism of the beta(2)-adrenergic receptor on response to regular use of albuterol in asthma

Autor: E, Israel, J M, Drazen, S B, Liggett, H A, Boushey, R M, Cherniack, V M, Chinchilli, D M, Cooper, J V, Fahy, J E, Fish, J G, Ford, M, Kraft, S, Kunselman, S C, Lazarus, R F, Lemanske, R J, Martin, D E, McLean, S P, Peters, E K, Silverman, C A, Sorkness, S J, Szefler, S T, Weiss, C N, Yandava

Publikováno v: International archives of allergy and immunology. 124(1-3)

Regular use of inhaled beta-adrenergic agonists may have adverse effects in some asthma patients. Polymorphisms of the beta(2)-adrenergic receptor (beta(2)-AR) can affect its regulation; however, results of smaller studies of the effects of such poly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9015511320f33c30858e90a8eb525ae3
https://pubmed.ncbi.nlm.nih.gov/11306963

An evaluation of colchicine as an alternative to inhaled corticosteriods in moderate asthma. National Heart, Lung, and Blood Institute's Asthma Clinical Research Network

Autor: J E, Fish, S P, Peters, C V, Chambers, S J, McGeady, K R, Epstein, H A, Boushey, R M, Cherniack, V M, Chinchilli, J M, Drazen, J V, Fahy, S S, Hurd, E, Israel, S C, Lazarus, R F, Lemanske, R J, Martin, E A, Mauger, C, Sorkness, S J, Szefler

Publikováno v: American journal of respiratory and critical care medicine. 156(4 Pt 1)

Colchicine demonstrates an array of anti-inflammatory properties of potential relevance to asthma. However, the efficacy of colchicine as an alternative to inhaled corticosteroid therapy for asthma is unknown. Five centers participated in a controlle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0e6a33aaf673db370e60085db8d04a6c
https://pubmed.ncbi.nlm.nih.gov/9351617

Pulmonary responses to purified zinc oxide fume

Autor: W G, Kuschner, A, D'Alessandro, S F, Wintermeyer, H, Wong, H A, Boushey, P D, Blanc

Publikováno v: Journal of investigative medicine : the official publication of the American Federation for Clinical Research. 43(4)

Metal fume fever is a flu-like illness caused by zinc oxide fume inhalation and mediated by unknown mechanisms. It is one of a group of work-related febrile inhalational syndromes. We studied bronchoalveolar lavage (BAL) obtained from cigarette smoki

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5164d7c4a1aa74f5e8b0aed99fb9789d
https://pubmed.ncbi.nlm.nih.gov/7552586