The BCL-2 family member BOK promotes KRAS-driven lung cancer progression in a p53-dependent manner

Autor: Meinhardt, Anna-Lena, Munkhbaatar, Enkhtsetseg, H��ckendorf, Ulrike, Dietzen, Michelle, Dechant, Marta, Anton, Martina, Jacob, Anne, Steiger, Katja, Weichert, Wilko, Brcic, Luka, McGranahan, Nicholas, Branca, Caterina, Kaufmann, Thomas, Dengler, Michael A, Jost, Philipp J

Publikováno v: Meinhardt, Anna-Lena; Munkhbaatar, Enkhtsetseg; Höckendorf, Ulrike; Dietzen, Michelle; Dechant, Marta; Anton, Martina; Jacob, Anne; Steiger, Katja; Weichert, Wilko; Brcic, Luka; McGranahan, Nicholas; Branca, Caterina; Kaufmann, Thomas; Dengler, Michael A; Jost, Philipp J (2022). The BCL-2 family member BOK promotes KRAS-driven lung cancer progression in a p53-dependent manner. Oncogene, 41(9), pp. 1376-1382. Springer Nature 10.1038/s41388-021-02161-1

A variety of cancer entities are driven by KRAS mutations, which remain difficult to target clinically. Survival pathways, such as resistance to cell death, may represent a promising treatment approach in KRAS mutated cancers. Based on the frequently

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https://pubmed.ncbi.nlm.nih.gov/35091677