Germ line variant GFI1-36N affects DNA repair and sensitizes AML cells to DNA damage and repair therapy.

Autor: Frank D; Department of Medicine A, Hematology, Oncology and Pneumology, University Hospital Münster, Münster, Germany.; Department of Hematology and Stem Cell Transplantation, University Hospital Essen, Essen, Germany., Patnana PK; Department of Medicine A, Hematology, Oncology and Pneumology, University Hospital Münster, Münster, Germany.; Department of Hematology and Stem Cell Transplantation, University Hospital Essen, Essen, Germany.; Department of Hematology and Oncology, University Hospital of Schleswig-Holstein, University Cancer Center Schleswig-Holstein, University of Lübeck, Lübeck, Germany., Vorwerk J; Department of Medicine A, Hematology, Oncology and Pneumology, University Hospital Münster, Münster, Germany., Mao L; Proteomics and Cancer Cell Signaling Group, Clinical Cooperation Unit Pediatric Leukemia, German Cancer Research Center and Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg, Germany., Gopal LM; Proteomics and Cancer Cell Signaling Group, Clinical Cooperation Unit Pediatric Leukemia, German Cancer Research Center and Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg, Germany., Jung N; Proteomics and Cancer Cell Signaling Group, Clinical Cooperation Unit Pediatric Leukemia, German Cancer Research Center and Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg, Germany., Hennig T; Proteomics and Cancer Cell Signaling Group, Clinical Cooperation Unit Pediatric Leukemia, German Cancer Research Center and Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg, Germany., Ruhnke L; Department of Internal Medicine I, University Hospital Dresden, Technical University Dresden, Dresden, Germany., Frenz JM; Proteomics and Cancer Cell Signaling Group, Clinical Cooperation Unit Pediatric Leukemia, German Cancer Research Center and Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg, Germany., Kuppusamy M; Proteomics and Cancer Cell Signaling Group, Clinical Cooperation Unit Pediatric Leukemia, German Cancer Research Center and Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg, Germany., Autry R; Hopp Children's Cancer Center, Heidelberg, Germany., Wei L; Department of Medicine A, Hematology, Oncology and Pneumology, University Hospital Münster, Münster, Germany.; Institute of Medical Informatics, University of Münster, Münster, Germany., Sun K; Department of Medicine A, Hematology, Oncology and Pneumology, University Hospital Münster, Münster, Germany., Mohammed Ahmed HM; Department of Medicine A, Hematology, Oncology and Pneumology, University Hospital Münster, Münster, Germany.; Department of Hematology and Oncology, University Hospital of Schleswig-Holstein, University Cancer Center Schleswig-Holstein, University of Lübeck, Lübeck, Germany., Künstner A; Medical Systems Biology Group, Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.; Institute for Cardiogenetics, University of Lübeck, Lübeck, Germany., Busch H; Medical Systems Biology Group, Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.; Institute for Cardiogenetics, University of Lübeck, Lübeck, Germany., Müller H; MLL Munich Leukemia Laboratory, Munich, Germany., Hutter S; MLL Munich Leukemia Laboratory, Munich, Germany., Hoermann G; MLL Munich Leukemia Laboratory, Munich, Germany., Liu L; Department of Medicine A, Hematology, Oncology and Pneumology, University Hospital Münster, Münster, Germany.; Department of Hematology, First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China., Xie X; Department of Medicine A, Hematology, Oncology and Pneumology, University Hospital Münster, Münster, Germany.; Department of Hematology-Oncology, Chongqing University Cancer Hospital, Chongqing, China., Al-Matary Y; Department of Dermatology, University Hospital Essen, Essen, Germany., Nimmagadda SC; Department of Medicine A, Hematology, Oncology and Pneumology, University Hospital Münster, Münster, Germany.; Department of Hematology and Oncology, University Hospital of Schleswig-Holstein, University Cancer Center Schleswig-Holstein, University of Lübeck, Lübeck, Germany., Cano FC; Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany., Heuser M; Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany., Thol F; Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany., Göhring G; Department of Human Genetics, Hannover Medical School, Hannover, Germany., Steinemann D; Department of Human Genetics, Hannover Medical School, Hannover, Germany., Thomale J; Institute of Cell Biology, University Hospital Essen, Essen, Germany., Leitner T; Department of Hematology and Oncology, University Hospital of Schleswig-Holstein, University Cancer Center Schleswig-Holstein, University of Lübeck, Lübeck, Germany., Fischer A; Institute of Molecular Oncology and Functional Genomics, School of Medicine, Technische Universität München, Munich, Germany.; Center for Translational Cancer Research, School of Medicine, Technische Universität München, Munich, Germany., Rad R; Institute of Molecular Oncology and Functional Genomics, School of Medicine, Technische Universität München, Munich, Germany.; Center for Translational Cancer Research, School of Medicine, Technische Universität München, Munich, Germany.; Department of Medicine II, Klinikum Rechts der Isar, School of Medicine, Technische Universität München, Munich, Germany., Röllig C; Hopp Children's Cancer Center, Heidelberg, Germany., Altmann H; Hopp Children's Cancer Center, Heidelberg, Germany., Kunadt D; Hopp Children's Cancer Center, Heidelberg, Germany., Berdel WE; Department of Medicine A, Hematology, Oncology and Pneumology, University Hospital Münster, Münster, Germany., Hüve J; Fluorescence Microscopy Facility Münster, Institute of Medical Physics and Biophysics, University of Münster, Münster, Germany., Neumann F; Fluorescence Microscopy Facility Münster, Institute of Medical Physics and Biophysics, University of Münster, Münster, Germany.; Refined Laser Systems GmbH, Münster, Germany., Klingauf J; Fluorescence Microscopy Facility Münster, Institute of Medical Physics and Biophysics, University of Münster, Münster, Germany.; Institute of Medical Physics and Biophysics, University of Münster, Münster, Germany., Calderon V; Bioinformatic Core Facility, Institut de Recherches Cliniques de Montréal, Montréal, QC, Canada., Opalka B; Department of Hematology and Stem Cell Transplantation, University Hospital Essen, Essen, Germany., Dührsen U; Department of Hematology and Stem Cell Transplantation, University Hospital Essen, Essen, Germany., Rosenbauer F; Institute of Molecular Tumor Biology, Faculty of Medicine, University of Münster, Münster, Germany., Dugas M; Institute of Medical Informatics, University Hospital Heidelberg, Heidelberg, Germany., Varghese J; Institute of Medical Informatics, University of Münster, Münster, Germany., Reinhardt HC; Department of Hematology and Stem Cell Transplantation, University Hospital Essen, Essen, Germany., von Bubnoff N; Department of Hematology and Oncology, University Hospital of Schleswig-Holstein, University Cancer Center Schleswig-Holstein, University of Lübeck, Lübeck, Germany., Möröy T; Institut de Recherches Cliniques de Montréal, Montreal, QC, Canada.; Division of Experimental Medicine, McGill University, Montreal, QC, Canada.; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC, Canada., Lenz G; Department of Medicine A, Hematology, Oncology and Pneumology, University Hospital Münster, Münster, Germany., Batcha AMN; Institute of Medical Data Processing, Biometrics and Epidemiology, Faculty of Medicine, Ludwig Maximilians University Munich, Munich, Germany.; Data Integration for Future Medicine, Ludwig Maximilian University Munich, Munich, Germany., Giorgi M; Roswell Park Comprehensive Cancer Center, Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY., Selvam M; Roswell Park Comprehensive Cancer Center, Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY., Wang E; Roswell Park Comprehensive Cancer Center, Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY., McWeeney SK; Division of Bioinformatics and Computational Biology, Department of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland, OR.; Knight Cancer Institute, Oregon Health & Science University, Portland, OR.; Oregon Clinical and Translational Research Institute, Oregon Health & Science University, Portland, OR., Tyner JW; Knight Cancer Institute, Oregon Health & Science University, Portland, OR.; Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, OR., Stölzel F; Department of Internal Medicine I, University Hospital Dresden, Technical University Dresden, Dresden, Germany.; Department of Medicine II, Division for Stem Cell Transplantation and Cellular Immunotherapy, University Cancer Center Schleswig-Holstein, University Hospital Schleswig-Holstein Kiel, Christian Albrecht University Kiel, Kiel, Germany., Mann M; Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Munich, Germany., Jayavelu AK; Proteomics and Cancer Cell Signaling Group, Clinical Cooperation Unit Pediatric Leukemia, German Cancer Research Center and Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg, Germany.; Hopp Children's Cancer Center, Heidelberg, Germany.; Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Munich, Germany.; Molecular Medicine Partnership Unit, European Molecular Biology Laboratory and Medical Faculty, University of Heidelberg, Heidelberg, Germany., Khandanpour C; Department of Medicine A, Hematology, Oncology and Pneumology, University Hospital Münster, Münster, Germany.; Department of Hematology and Stem Cell Transplantation, University Hospital Essen, Essen, Germany.; Department of Hematology and Oncology, University Hospital of Schleswig-Holstein, University Cancer Center Schleswig-Holstein, University of Lübeck, Lübeck, Germany.

Publikováno v: Blood [Blood] 2023 Dec 21; Vol. 142 (25), pp. 2175-2191.

Switching behaviour of dSTORM dyes in glycerol-containing buffer.

Autor: Goossen-Schmidt NC; Fluorescence Microscopy Facility Münster (FM)², Institute of Medical Physics and Biophysics, Center For NanoTechnology (CeNTech), Heisenbergstraße 11, 48149, Münster, Germany.; Department of Cellular Biophysics, Institute of Medical Physics and Biophysics, University of Münster, Robert-Koch-Straße 31, 48149, Münster, Germany., Schnieder M; Fluorescence Microscopy Facility Münster (FM)², Institute of Medical Physics and Biophysics, Center For NanoTechnology (CeNTech), Heisenbergstraße 11, 48149, Münster, Germany.; Department of Cellular Biophysics, Institute of Medical Physics and Biophysics, University of Münster, Robert-Koch-Straße 31, 48149, Münster, Germany., Hüve J; Fluorescence Microscopy Facility Münster (FM)², Institute of Medical Physics and Biophysics, Center For NanoTechnology (CeNTech), Heisenbergstraße 11, 48149, Münster, Germany. jana.hueve@uni-muenster.de.; Department of Cellular Biophysics, Institute of Medical Physics and Biophysics, University of Münster, Robert-Koch-Straße 31, 48149, Münster, Germany. jana.hueve@uni-muenster.de., Klingauf J; Fluorescence Microscopy Facility Münster (FM)², Institute of Medical Physics and Biophysics, Center For NanoTechnology (CeNTech), Heisenbergstraße 11, 48149, Münster, Germany. klingauf@uni-muenster.de.; Department of Cellular Biophysics, Institute of Medical Physics and Biophysics, University of Münster, Robert-Koch-Straße 31, 48149, Münster, Germany. klingauf@uni-muenster.de.

Publikováno v: Scientific reports [Sci Rep] 2020 Aug 13; Vol. 10 (1), pp. 13746. Date of Electronic Publication: 2020 Aug 13.

An atlas of bloodstream-accessible bone marrow proteins for site-directed therapy of acute myeloid leukemia

Autor: Rolf M. Mesters, Dominik Kentrup, Benk As, Linus Angenendt, Christian Schwöppe, Caroline Brand, Stefan Reuter, Christoph Schliemann, Alexander Martens, Hüve J, Wolfgang E. Berdel, Tim Sauer, Jan-Henrik Mikesch, Dario Neri, Carsten Müller-Tidow, Neumann F, Georg Lenz, Wolfgang Hartmann, E. Wardelmann, Roesli C, Torsten Kessler, LH Schmidt

Publikováno v: Leukemia. 32:510-519

The concept of arming antibodies with bioactive payloads for a site-specific therapy of cancer has gained considerable interest in recent years. However, a successful antibody-based targeting approach critically relies on the availability of a tumor-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7024d8374045e06af1502360b615cf23
https://doi.org/10.1038/leu.2017.208

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Monitoring of activity-driven trafficking of endogenous synaptic proteins through proximity labeling.

Autor: Pascual-Caro, Carlos¹ (AUTHOR), de Juan-Sanz, Jaime¹ (AUTHOR) jaime.dejuansanz@icm-institute.org

Publikováno v: PLoS Biology. 10/28/2024, Vol. 22 Issue 10, p1-25. 25p.