Výsledky vyhledávání - "Hümpel, Michael"

Safety and pharmacokinetics of the orally available antiprionic compound PRI-002: A single and multiple ascending dose phase I study

Autor: Kutzsche, Janine, Jürgens, Dagmar, Willuweit, Antje, Adermann, Knut, Fuchs, Carola, Simons, Stefanie, Windisch, Manfred, Hümpel, Michael, Rossberg, Wolfgang, Wolzt, Michael, Willbold, Dieter

Publikováno v: Alzheimer's & dementia / Translational research & clinical interventions Translational research & clinical interventions [...] 6(1), e12001 (2020). doi:10.1002/trc2.12001
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 6, Iss 1, Pp n/a-n/a (2020)
Alzheimer's & Dementia : Translational Research & Clinical Interventions

Introduction PRI‐002 is an orally available anti–amyloid beta (Aβ) prionic compound developed for direct disassembly of toxic Aβ oligomers relevant to Alzheimer's disease. Methods Two placebo‐controlled clinical phase I trials with oral dosin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::1d153c392c54f863530c6a982549567a
https://pubmed.ncbi.nlm.nih.gov/32211506

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Akademický článek

Tissue specificity of 8-prenylnaringenin: Protection from ovariectomy induced bone loss with minimal trophic effects on the uterus

Autor: Hümpel, Michael¹ michael.huempel@schering.de, Isaksson, Päivi², Schaefer, Olaf¹, Kaufmann, Ulrike¹, Ciana, Paolo³, Maggi, Adriana³, Schleuning, Wolf-Dieter⁴

Publikováno v: Journal of Steroid Biochemistry & Molecular Biology. Nov2005, Vol. 97 Issue 3, p299-305. 7p.

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Akademický článek

Investigations on the Percutaneous Absorption of the Antidepressant Rolipram in Vitro and in Vivo.

Autor: Hadgraft, Jonathan, Hill, Stephanie, Hümpel, Michael, Johnston, Linda, Lever, Lawrence, Marks, Ronald, Murphy, T., Rapier, Catherine

Publikováno v: Pharmaceutical Research; Dec1990, Vol. 7 Issue 12, p1307-1312, 6p

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Akademický článek

Disposition of oral lisuride in parkinson's disease.

Autor: Burns, R Stanley, Gopinathan, G, Hümpel, Michael, Dorow, Rainer, Calne, Donald B

Publikováno v: Clinical Pharmacology & Therapeutics; Apr1984, Vol. 35 Issue 4, p548-556, 9p

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Kinetics and biotransformation of lormetazepam.

Autor: Hümpel, Michael, Nieuweboer, Bob, Milius, Waltraud, Hanke, Heidrun, Wendt, Hans

Publikováno v: Clinical Pharmacology & Therapeutics; Nov1980, Vol. 28 Issue 5, p673-679, 7p

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Akademický článek

8-Prenyl naringenin is a potent ERα selective phytoestrogen present in hops and beer

Autor: Schaefer, Olaf¹, Hümpel, Michael¹, Fritzemeier, Karl-Heinrich¹, Bohlmann, Rolf¹, Schleuning, Wolf-Dieter² wd.schleuning@research.paion.de

Publikováno v: Journal of Steroid Biochemistry & Molecular Biology. Feb2003, Vol. 84 Issue 2/3, p359. 2p.

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Protein binding of active ingredients and comparison of serum ethinyl estradiol sex hormone-binding globulin, corticosteroid-binding globulin, and cortisol levels in women using a combination of gestodene/ ethinyl estradiol (Femovan) or a combination of desogestrel/ ethinyl estradiol (Marvelon) and single-dose ethinyl estradiol bioequivalence from both oral contraceptives

Autor: Hümpel, Michael, Täuber, Ulrich, Kuhnz, Wilhelm, Pfeffer, Michael, Brill, Klaus, Heithecker, Renate, Louton, Thomas, Steinberg, Bernd, Seifert, Wolfgang, Schütt, Barbara

Publikováno v: In American Journal of Obstetrics and Gynecology 1990 163(1) Part 2:329-333

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Safety and pharmacokinetics of the orally available antiprionic compound PRI-002: A single and multiple ascending dose phase I study.

Autor: Kutzsche J; Structural Biochemistry (ICS-6) Institute of Complex Systems Jülich Germany., Jürgens D; Structural Biochemistry (ICS-6) Institute of Complex Systems Jülich Germany., Willuweit A; Medical Imaging Physics (INM-4) Institute of Neuroscience and Medicine Jülich Germany., Adermann K; Chemical & Pharmaceutical Consulting Hannover Germany., Fuchs C; Department of Clinical Pharmacology Medical University of Vienna Vienna Austria., Simons S; Structural Biochemistry (ICS-6) Institute of Complex Systems Jülich Germany.; Heinrich-Heine-Universität Düsseldorf Institut für Physikalische Biologie Düsseldorf Germany., Windisch M; NeuroScios GmbH Graz Austria., Hümpel M; KAIROSmetics UG Berlin Germany., Rossberg W; ConsultWMR Potsdam Germany., Wolzt M; Department of Clinical Pharmacology Medical University of Vienna Vienna Austria., Willbold D; Structural Biochemistry (ICS-6) Institute of Complex Systems Jülich Germany.; Heinrich-Heine-Universität Düsseldorf Institut für Physikalische Biologie Düsseldorf Germany.

Publikováno v: Alzheimer's & dementia (New York, N. Y.) [Alzheimers Dement (N Y)] 2020 Mar 20; Vol. 6 (1), pp. e12001. Date of Electronic Publication: 2020 Mar 20 (Print Publication: 2020).

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Development of a radioimmunoassay for the quantitative determination of 8-prenylnaringenin in biological matrices.

Autor: Schaefer O; Research Laboratories Schering AG, 13342 Berlin, Germany., Bohlmann R, Schleuning WD, Schulze-Forster K, Hümpel M

Publikováno v: Journal of agricultural and food chemistry [J Agric Food Chem] 2005 Apr 20; Vol. 53 (8), pp. 2881-9.

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