Zobrazeno 1 - 10
of 276
pro vyhledávání: '"Hülya Bayır"'
Autor:
Adelheid Weidinger, Nadja Milivojev, Arthur Hosmann, J. Catharina Duvigneau, Csaba Szabo, Gabor Törö, Laurin Rauter, Annette Vaglio-Garro, Garik V. Mkrtchyan, Lidia Trofimova, Rinat R. Sharipov, Alexander M. Surin, Irina A. Krasilnikova, Vsevolod G. Pinelis, Laszlo Tretter, Rudolf Moldzio, Hülya Bayır, Valerian E. Kagan, Victoria I. Bunik, Andrey V. Kozlov
Publikováno v:
Redox Biology, Vol 62, Iss , Pp 102669- (2023)
Brain injury is accompanied by neuroinflammation, accumulation of extracellular glutamate and mitochondrial dysfunction, all of which cause neuronal death. The aim of this study was to investigate the impact of these mechanisms on neuronal death.Pati
Externí odkaz:
https://doaj.org/article/427e252d29b84f7382a2fca0e3a2b261
Autor:
Zhongyuan Bao, Yinlong Liu, Binglin Chen, Zong Miao, Yiming Tu, Chong Li, Honglu Chao, Yangfan Ye, Xiupeng Xu, Guangchi Sun, Pengzhan Zhao, Ning Liu, Yan Liu, Xiaoming Wang, Sin Man Lam, Valerian E. Kagan, Hülya Bayır, Jing Ji
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Prokineticin-2 (Prok2) is a secreted protein involved in many physiological processes. Here, the authors show that Prok2 prevents neuronal cell ferroptosis after traumatic brain injury and its administration before cortical injury reduces neuronal de
Externí odkaz:
https://doaj.org/article/014cfde24f7647fc8390c531c4a06ca5
Autor:
Alexander Beatty, Tanu Singh, Yulia Y. Tyurina, Vladimir A. Tyurin, Svetlana Samovich, Emmanuelle Nicolas, Kristen Maslar, Yan Zhou, Kathy Q. Cai, Yinfei Tan, Sebastian Doll, Marcus Conrad, Aravind Subramanian, Hülya Bayır, Valerian E. Kagan, Ulrike Rennefahrt, Jeffrey R. Peterson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Inhibition of the lipid peroxidase GPX4 promotes ferroptotic cell death. Here, the authors identify a complementary approach using conjugated linolenic fatty acids that trigger lipid peroxidation and ferroptosis via ACSL1, DGAT1/2, and neutral lipids
Externí odkaz:
https://doaj.org/article/a15fa8f172aa4a2c98e5449033292272
Autor:
Andrew M. Lamade, Limin Wu, Haider H. Dar, Heather L. Mentrup, Indira H. Shrivastava, Michael W. Epperly, Claudette M. St Croix, Yulia Y. Tyurina, Tamil S. Anthonymuthu, Qin Yang, Aleksandr A. Kapralov, Zhentai Huang, Gaowei Mao, Andrew A. Amoscato, Zachary E. Hier, Margarita A. Artyukhova, Galina Shurin, Joel C. Rosenbaum, Peter J. Gough, John Bertin, Andrew P. VanDemark, Simon C. Watkins, Kevin P. Mollen, Ivet Bahar, Joel S. Greenberger, Valerian E. Kagan, Michael J. Whalen, Hülya Bayır
Publikováno v:
Redox Biology, Vol 50, Iss , Pp 102232- (2022)
Ferroptosis and necroptosis are two pro-inflammatory cell death programs contributing to major pathologies and their inhibition has gained attention to treat a wide range of disease states. Necroptosis relies on activation of RIP1 and RIP3 kinases. F
Externí odkaz:
https://doaj.org/article/f183853d46e94325b02ce4c0422c4965
Autor:
Haider H. Dar, Michael W. Epperly, Vladimir A. Tyurin, Andrew A. Amoscato, Tamil S. Anthonymuthu, Austin B. Souryavong, Alexander A. Kapralov, Galina V. Shurin, Svetlana N. Samovich, Claudette M. St. Croix, Simon C. Watkins, Sally E. Wenzel, Rama K. Mallampalli, Joel S. Greenberger, Hülya Bayır, Valerian E. Kagan, Yulia Y. Tyurina
Publikováno v:
JCI Insight, Vol 7, Iss 4 (2022)
Total body irradiation (TBI) targets sensitive bone marrow hematopoietic cells and gut epithelial cells, causing their death and inducing a state of immunodeficiency combined with intestinal dysbiosis and nonproductive immune responses. We found enha
Externí odkaz:
https://doaj.org/article/064649aa63e64d92892a0366bc434be8
Autor:
Sehwan Jang, Xavier R. Chapa-Dubocq, Yulia Y. Tyurina, Claudette M. St Croix, Alexandr A. Kapralov, Vladimir A. Tyurin, Hülya Bayır, Valerian E. Kagan, Sabzali Javadov
Publikováno v:
Redox Biology, Vol 45, Iss , Pp 102021- (2021)
Ferroptosis is a programmed iron-dependent cell death associated with peroxidation of lipids particularly, phospholipids. Several studies suggested a possible contribution of mitochondria to ferroptosis although the mechanisms underlying mitochondria
Externí odkaz:
https://doaj.org/article/cb3b575956b2475e98ff7456615dc970
Publikováno v:
Neurobiology of Disease, Vol 122, Iss , Pp 9-15 (2019)
It is established that increased autophagy is readily detectable after various types of acute brain injury, including trauma, focal and global cerebral ischemia. What remains controversial, however, is whether this heightened detection of autophagy i
Externí odkaz:
https://doaj.org/article/c7968af309a04298b68eba08fa96c6f6
Autor:
Tamil S. Anthonymuthu, Yulia Y. Tyurina, Wan-Yang Sun, Karolina Mikulska-Ruminska, Indira H. Shrivastava, Vladimir A. Tyurin, Fatma B. Cinemre, Haider H. Dar, Andrew P. VanDemark, Theodore R. Holman, Yoel Sadovsky, Brent R. Stockwell, Rong-Rong He, Ivet Bahar, Hülya Bayır, Valerian E. Kagan
Publikováno v:
Redox Biology, Vol 38, Iss , Pp 101744- (2021)
Hydroperoxy-eicosatetraenoyl-phosphatidylethanolamine (HpETE-PE) is a ferroptotic cell death signal. HpETE-PE is produced by the 15-Lipoxygenase (15LOX)/Phosphatidylethanolamine Binding Protein-1 (PEBP1) complex or via an Fe-catalyzed non-enzymatic r
Externí odkaz:
https://doaj.org/article/2be5ba9f39624a43ae53e3556263b20b
Autor:
Karolina Mikulska-Ruminska, Tamil S. Anthonymuthu, Anastasia Levkina, Indira H. Shrivastava, Alexandr A. Kapralov, Hülya Bayır, Valerian E. Kagan, Ivet Bahar
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 10, p 5253 (2021)
We recently discovered an anti-ferroptotic mechanism inherent to M1 macrophages whereby high levels of NO● suppressed ferroptosis via inhibition of hydroperoxy-eicosatetraenoyl-phosphatidylethanolamine (HpETE-PE) production by 15-lipoxygenase (15LO
Externí odkaz:
https://doaj.org/article/326df8e3eb9a4a9c9eaa80be0a2d369b
Autor:
Emin Fidan, Lesley M. Foley, Lee Ann New, Henry Alexander, Patrick M. Kochanek, T. Kevin Hitchens, Hülya Bayır
Publikováno v:
ASN Neuro, Vol 10 (2018)
Mild traumatic brain injury (mTBI) in children is a common and serious public health problem. Traditional neuroimaging findings in children who sustain mTBI are often normal, putting them at risk for repeated mTBI (rmTBI). There is a need for more se
Externí odkaz:
https://doaj.org/article/b2d6a50654e14c23b869cacecd8dd25f