Zobrazeno 1 - 10 of 308 pro vyhledávání: '"Højfeldt JW"'
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EZH2 is a potential therapeutic target for H3K27M-mutant pediatric gliomas
Autor: Mohammad F, Weissmann S, Leblanc B, Pandey DP, Højfeldt JW, Comet I, Zheng C, Johansen JV, Rapin N, Porse BT, Tvardovskiy A, Jensen ON, Gene-Olaciregui N, Lavarino C, Suñol M, de Torres C, Mora J, Carcaboso AM, Helin K
Publikováno v: NATURE MEDICINE
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
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r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Fundació Sant Joan de Déu
Diffuse intrinsic pontine glioma (DIPG) is an aggressive brain tumor that is located in the pons and primarily affects children. Nearly 80% of DIPGs harbor mutations in histone H3 genes, wherein lysine 27 is substituted with methionine (H3K27M). H3K2
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::032b1462935111e812c28777f09a13cb
http://fundanet.fsjd.org/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=10918
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2
Akademický článek
MPP8 is essential for sustaining self-renewal of ground-state pluripotent stem cells.
Autor: Müller I; Biotech Research and Innovation Centre (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; The Novo Nordisk Foundation for Stem Cell Biology (DanStem), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Cell Biology Program and Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Moroni AS; Biotech Research and Innovation Centre (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; The Novo Nordisk Foundation for Stem Cell Biology (DanStem), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Shlyueva D; Biotech Research and Innovation Centre (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; The Novo Nordisk Foundation for Stem Cell Biology (DanStem), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Cell Biology Program and Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Sahadevan S; Biotech Research and Innovation Centre (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; The Novo Nordisk Foundation for Stem Cell Biology (DanStem), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Schoof EM; The Finsen Laboratory, Rigshospitalet and Biotech Research and Innovation Centre (BRIC), Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Biotechnology and Biomedicine, Technical University of Denmark, Lyngby, Denmark., Radzisheuskaya A; Biotech Research and Innovation Centre (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; The Novo Nordisk Foundation for Stem Cell Biology (DanStem), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Cell Biology Program and Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Højfeldt JW; Biotech Research and Innovation Centre (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; The Novo Nordisk Foundation for Stem Cell Biology (DanStem), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Tatar T; Biotech Research and Innovation Centre (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; The Novo Nordisk Foundation for Stem Cell Biology (DanStem), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Koche RP; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Huang C; Cell Biology Program and Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Helin K; Biotech Research and Innovation Centre (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. helink@mskcc.org.; The Novo Nordisk Foundation for Stem Cell Biology (DanStem), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. helink@mskcc.org.; Cell Biology Program and Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA. helink@mskcc.org.
Publikováno v: Nature communications [Nat Commun] 2021 May 24; Vol. 12 (1), pp. 3034. Date of Electronic Publication: 2021 May 24.
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3
Akademický článek
PTEN depletion reduces H3K27me3 levels to promote epithelial-to-mesenchymal transition in epithelial colorectal cancer cells.
Autor: Ghobashi, Ahmed H.1,2,3 (AUTHOR), Kimani, Jane W.2 (AUTHOR), Ladaika, Christopher A.1,2,3 (AUTHOR), O'Hagan, Heather M.2,3,4 (AUTHOR) hmohagan@iu.edu
Publikováno v: PLoS ONE. 11/19/2024, Vol. 19 Issue 11, p1-23. 23p.
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4
Akademický článek
Refractory testicular germ cell tumors are highly sensitive to the targeting of polycomb pathway demethylases KDM6A and KDM6B.
Autor: Shokry, Doha1,2 (AUTHOR), Khan, Mehwish W.1 (AUTHOR), Powell, Christine1 (AUTHOR), Johnson, Samantha1 (AUTHOR), Rennels, Brayden C.1 (AUTHOR), Boyd, Raya I.1 (AUTHOR), Sun, Zhengyang1 (AUTHOR), Fazal, Zeeshan1 (AUTHOR), Freemantle, Sarah J.1 (AUTHOR), Parker, Maryanna H.3 (AUTHOR), Vieson, Miranda D.3,4 (AUTHOR), Samuelson, Jonathan P.3 (AUTHOR), Spinella, Michael J.1,5,6 (AUTHOR) spinella@illinois.edu, Singh, Ratnakar1 (AUTHOR) rsingh02@illinois.edu
Publikováno v: Cell Communication & Signaling. 10/31/2024, Vol. 22 Issue 1, p1-15. 15p.
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5
Akademický článek
Epigenetic Biomarkers and the Wnt/β-Catenin Pathway in Opisthorchis viverrini-associated Cholangiocarcinoma: A Scoping Review on Therapeutic Opportunities.
Autor: Kafle, Alok1,2 (AUTHOR), Suttiprapa, Sutas1,2 (AUTHOR) sutasu@kku.ac.th, Muhammad, Mubarak3 (AUTHOR), Tenorioa, Jan Clyden B.1,2 (AUTHOR), Mahato, Roshan Kumar4 (AUTHOR), Sahimin, Norhidayu5 (AUTHOR), Loong, Shih Keng5 (AUTHOR)
Publikováno v: PLoS Neglected Tropical Diseases. 9/5/2024, Vol. 18 Issue 9, p1-34. 34p.
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6
Akademický článek
Cancer, metastasis, and the epigenome.
Autor: Kiri, Saurav1 (AUTHOR) sa939682@ucf.edu, Ryba, Tyrone2 (AUTHOR) tryba@ncf.edu
Publikováno v: Molecular Cancer. 8/2/2024, Vol. 23 Issue 1, p1-27. 27p.
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7
Akademický článek
Non-core Subunits of the PRC2 Complex Are Collectively Required for Its Target-Site Specificity.
Autor: Højfeldt JW; Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen N 2200, Denmark; The Novo Nordisk Foundation Center for Stem Cell Biology (DanStem), University of Copenhagen, Copenhagen N 2200, Denmark., Hedehus L; Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen N 2200, Denmark; The Novo Nordisk Foundation Center for Stem Cell Biology (DanStem), University of Copenhagen, Copenhagen N 2200, Denmark., Laugesen A; Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen N 2200, Denmark; The Novo Nordisk Foundation Center for Stem Cell Biology (DanStem), University of Copenhagen, Copenhagen N 2200, Denmark., Tatar T; Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen N 2200, Denmark; The Novo Nordisk Foundation Center for Stem Cell Biology (DanStem), University of Copenhagen, Copenhagen N 2200, Denmark., Wiehle L; Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen N 2200, Denmark; The Novo Nordisk Foundation Center for Stem Cell Biology (DanStem), University of Copenhagen, Copenhagen N 2200, Denmark., Helin K; Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen N 2200, Denmark; The Novo Nordisk Foundation Center for Stem Cell Biology (DanStem), University of Copenhagen, Copenhagen N 2200, Denmark; Cell Biology Program and Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY 10065, USA. Electronic address: helink@mskcc.org.
Publikováno v: Molecular cell [Mol Cell] 2019 Nov 07; Vol. 76 (3), pp. 423-436.e3. Date of Electronic Publication: 2019 Sep 11.
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8
Akademický článek
Molecular Mechanisms Directing PRC2 Recruitment and H3K27 Methylation.
Autor: Laugesen A; Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Ole Maaløes Vej 5, DK-2200 Copenhagen N, Denmark; The Novo Nordisk Foundation Center for Stem Cell Biology (DanStem), University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen N, Denmark., Højfeldt JW; Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Ole Maaløes Vej 5, DK-2200 Copenhagen N, Denmark; The Novo Nordisk Foundation Center for Stem Cell Biology (DanStem), University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen N, Denmark., Helin K; Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Ole Maaløes Vej 5, DK-2200 Copenhagen N, Denmark; The Novo Nordisk Foundation Center for Stem Cell Biology (DanStem), University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen N, Denmark; Cell Biology Program and Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center (MSKCC), 1275 York Avenue, New York, NY 10065, USA. Electronic address: helink@mskcc.org.
Publikováno v: Molecular cell [Mol Cell] 2019 Apr 04; Vol. 74 (1), pp. 8-18.
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9
Akademický článek
Accurate H3K27 methylation can be established de novo by SUZ12-directed PRC2.
Autor: Højfeldt JW; Biotech Research and Innovation Centre (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; The Novo Nordisk Foundation Center for Stem Cell Biology (DanStem), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Laugesen A; Biotech Research and Innovation Centre (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; The Novo Nordisk Foundation Center for Stem Cell Biology (DanStem), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Willumsen BM; Cell Biology and Physiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark., Damhofer H; Biotech Research and Innovation Centre (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; The Novo Nordisk Foundation Center for Stem Cell Biology (DanStem), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Hedehus L; Biotech Research and Innovation Centre (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; The Novo Nordisk Foundation Center for Stem Cell Biology (DanStem), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Tvardovskiy A; Department of Biochemistry and Molecular Biology, VILLUM Center for Bioanalytical Sciences, University of Southern Denmark, Odense, Denmark.; Institute of Functional Epigenetics, Helmholtz Zentrum München, Neuherberg, Germany., Mohammad F; Biotech Research and Innovation Centre (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; The Novo Nordisk Foundation Center for Stem Cell Biology (DanStem), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Jensen ON; Department of Biochemistry and Molecular Biology, VILLUM Center for Bioanalytical Sciences, University of Southern Denmark, Odense, Denmark., Helin K; Biotech Research and Innovation Centre (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. kristian.helin@bric.ku.dk.; The Novo Nordisk Foundation Center for Stem Cell Biology (DanStem), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. kristian.helin@bric.ku.dk.
Publikováno v: Nature structural & molecular biology [Nat Struct Mol Biol] 2018 Mar; Vol. 25 (3), pp. 225-232. Date of Electronic Publication: 2018 Feb 26.
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10
Akademický článek
A CRISPR/Cas9 screen in embryonic stem cells reveals that Mdm2 regulates totipotency exit.
Autor: Gao, Chen1,2 (AUTHOR), Gao, Xin1,3 (AUTHOR), Gao, Fei1,3 (AUTHOR), Du, Xuguang1,3 (AUTHOR) xuguangdu@cau.edu.cn, Wu, Sen1,3 (AUTHOR) swu@cau.edu.cn
Publikováno v: Communications Biology. 7/3/2024, p1-13. 13p.
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