Concizumab prophylaxis in people with haemophilia A or haemophilia B without inhibitors (explorer8): a prospective, multicentre, open-label, randomised, phase 3a trial.

Autor: Chowdary P; Katharine Dormandy Haemophilia and Thrombosis Centre, Royal Free London NHS Foundation Trust, London, UK; Department of Haematology, Cancer Institute, University College London, London, UK. Electronic address: p.chowdary@ucl.ac.uk., Angchaisuksiri P; Division of Hematology, Department of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand., Apte S; Department of Hematology, Sahyadri Specialty Hospitals, Pune, India., Astermark J; Institution of Translational Medicine, Lund University, Malmö, Sweden; Department of Hematology, Oncology and Radiation Physics, Skåne University Hospital, Malmö, Sweden., Benson G; Department of Haematology, Belfast Health and Social Care Trust, Belfast, UK., Chan AKC; Department of Pediatrics, McMaster University, Hamilton, ON, Canada., Jiménez Yuste V; Hematology Department, La Paz University Hospital, Universidad Autónoma Madrid, Madrid, Spain., Matsushita T; Department of Transfusion Medicine, Nagoya University Hospital, Nagoya, Japan., Høgh Nielsen AR; Novo Nordisk, Søborg, Denmark., Sathar J; Department of Hematology, Ampang Hospital, Kuala Lumpur, Malaysia., Sutton C; Department of Pediatrics and Child Health, Faculty of Health Sciences, University of Limpopo and Pietersburg and Mankweng Hospitals, Limpopo, South Africa., Šaulytė Trakymienė S; Clinic of Children's Diseases, Faculty of Medicine, Vilnius University Hospital Santaros Klinikos, Vilnius University, Vilnius, Lithuania., Tran H; Ronald Sawyers Haemophilia Centre, The Alfred Hospital, Melbourne, VIC, Australia; Australian Centre for Blood Diseases, Monash University, Melbourne, VIC, Australia., Villarreal Martinez L; Dr José Eleuterio González Monterrey University Hospital, Monterrey, México., Wheeler AP; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA., Windyga J; Department of Hemostasis Disorders and Internal Medicine, Laboratory of Hemostasis and Metabolic Diseases, Institute of Hematology and Transfusion Medicine, Warsaw, Poland., Young G; Hemostasis and Thrombosis Center, Children's Hospital of Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Thaung Zaw JJ; Novo Nordisk, Søborg, Denmark., Eichler H; Institute of Clinical Hemostaseology and Transfusion Medicine, Saarland University and University Hospital, Homburg, Germany.

Publikováno v: The Lancet. Haematology [Lancet Haematol] 2024 Dec; Vol. 11 (12), pp. e891-e904. Date of Electronic Publication: 2024 Nov 06.