Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Hévila Brognaro"'
Autor:
Patrick Y. A. Reinke, Robin Schubert, Dominik Oberthür, Marina Galchenkova, Aida Rahmani Mashhour, Sebastian Günther, Anaïs Chretien, Adam Round, Brandon Charles Seychell, Brenna Norton-Baker, Chan Kim, Christina Schmidt, Faisal H. M. Koua, Alexandra Tolstikova, Wiebke Ewert, Gisel Esperanza Peña Murillo, Grant Mills, Henry Kirkwood, Hévila Brognaro, Huijong Han, Jayanath Koliyadu, Joachim Schulz, Johan Bielecki, Julia Lieske, Julia Maracke, Juraj Knoska, Kristina Lorenzen, Lea Brings, Marcin Sikorski, Marco Kloos, Mohammad Vakili, Patrik Vagovic, Philipp Middendorf, Raphael de Wijn, Richard Bean, Romain Letrun, Seonghyun Han, Sven Falke, Tian Geng, Tokushi Sato, Vasundara Srinivasan, Yoonhee Kim, Oleksandr M. Yefanov, Luca Gelisio, Tobias Beck, Andrew S. Doré, Adrian P. Mancuso, Christian Betzel, Saša Bajt, Lars Redecke, Henry N. Chapman, Alke Meents, Dušan Turk, Winfried Hinrichs, Thomas J. Lane
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract The main protease (Mpro) of SARS-CoV-2 is critical for viral function and a key drug target. Mpro is only active when reduced; turnover ceases upon oxidation but is restored by re-reduction. This suggests the system has evolved to survive pe
Externí odkaz:
https://doaj.org/article/7a737b71ae764265a7f11a3df650ea0b
Autor:
Prabhu Rajaiah Prince, Janine Hochmair, Hévila Brognaro, Susanna Gevorgyan, Maximilian Franck, Robin Schubert, Kristina Lorenzen, Selin Yazici, Eckhard Mandelkow, Susanne Wegmann, Christian Betzel
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Tau is an intrinsically disordered neuronal protein in the central nervous system. Aggregated Tau is the main component of neurofibrillary tangles observed in Alzheimer’s disease. In vitro, Tau aggregation can be triggered by polyanionic c
Externí odkaz:
https://doaj.org/article/3a8096f753d74d81b89c1098d73793e0
Autor:
Vasundara Srinivasan, Hévila Brognaro, Prince R. Prabhu, Edmarcia Elisa de Souza, Sebastian Günther, Patrick Y. A. Reinke, Thomas J. Lane, Helen Ginn, Huijong Han, Wiebke Ewert, Janina Sprenger, Faisal H. M. Koua, Sven Falke, Nadine Werner, Hina Andaleeb, Najeeb Ullah, Bruno Alves Franca, Mengying Wang, Angélica Luana C. Barra, Markus Perbandt, Martin Schwinzer, Christina Schmidt, Lea Brings, Kristina Lorenzen, Robin Schubert, Rafael Rahal Guaragna Machado, Erika Donizette Candido, Danielle Bruna Leal Oliveira, Edison Luiz Durigon, Stephan Niebling, Angelica Struve Garcia, Oleksandr Yefanov, Julia Lieske, Luca Gelisio, Martin Domaracky, Philipp Middendorf, Michael Groessler, Fabian Trost, Marina Galchenkova, Aida Rahmani Mashhour, Sofiane Saouane, Johanna Hakanpää, Markus Wolf, Maria Garcia Alai, Dusan Turk, Arwen R. Pearson, Henry N. Chapman, Winfried Hinrichs, Carsten Wrenger, Alke Meents, Christian Betzel
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
Three natural phenolic compounds are found to bind to an allosteric site in SARS-CoV-2 papain-like protease and exhibit antiviral activity in vitro, showing potential as starting scaffolds for drug design.
Externí odkaz:
https://doaj.org/article/94a6b8437953446b80663a578e6c235a
Autor:
Aline Melro Murad, Hévila Brognaro, Sven Falke, Jasmin Lindner, Markus Perbandt, Celestin Mudogo, Robin Schubert, Carsten Wrenger, Christian Betzel
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Humanity is facing an increasing health threat caused by a variety of multidrug resistant bacteria. Within this scenario, Staphylococcus aureus, in particular methicillin resistant S. aureus (MRSA), is responsible for a number of hospital-ac
Externí odkaz:
https://doaj.org/article/3e25d1c42ea54569ba4278da4c2a3819
Autor:
Sophie C. Brandt, Hévila Brognaro, Arslan Ali, Bernhard Ellinger, Katharina Maibach, Martin Rühl, Carsten Wrenger, Hartmut Schlüter, Wilhelm Schäfer, Christian Betzel, Stefan Janssen, Martin Gand
Publikováno v:
Biotechnology for Biofuels, Vol 14, Iss 1, Pp 1-22 (2021)
Abstract Background The transition to a biobased economy involving the depolymerization and fermentation of renewable agro-industrial sources is a challenge that can only be met by achieving the efficient hydrolysis of biomass to monosaccharides. In
Externí odkaz:
https://doaj.org/article/ee191c8225854aee892e81b7b2eac1bf
Autor:
Wiebke Ewert, Sebastian Günther, Francesca Miglioli, Sven Falke, Patrick Y. A. Reinke, Stephan Niebling, Christian Günther, Huijong Han, Vasundara Srinivasan, Hévila Brognaro, Julia Lieske, Kristina Lorenzen, Maria M. Garcia-Alai, Christian Betzel, Mauro Carcelli, Winfried Hinrichs, Dominga Rogolino, Alke Meents
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
The papain-like protease (PLpro) of SARS-CoV-2 is essential for viral propagation and, additionally, dysregulation of the host innate immune system. Using a library of 40 potential metal-chelating compounds we performed an X-ray crystallographic scre
Externí odkaz:
https://doaj.org/article/5abf90b91d214accbdd2fa885322f8ed
Publikováno v:
Crystals, Vol 12, Iss 3, p 437 (2022)
The scientific discussion about classical and nonclassical nucleation theories has lasted for two decades so far. Recently, multiple nucleation pathways and the occurrence and role of metastable intermediates in crystallization processes have attract
Externí odkaz:
https://doaj.org/article/76b20e208a784dc7930dbd0b775b9239
Publikováno v:
Heliyon, Vol 5, Iss 12, Pp e03016- (2019)
Liquid-liquid phase separation (LLPS) phenomena have been observed in vitro as well as in vivo and came in focus of interdisciplinary research activities particularly aiming at understanding the physico-chemical pathways of LLPS and its functionality
Externí odkaz:
https://doaj.org/article/62e312a1274e4d3bb1ada35e2b522c6b
Autor:
Arslan Ali, Bernhard Ellinger, Sophie C. Brandt, Christian Betzel, Martin Rühl, Carsten Wrenger, Hartmut Schlüter, Wilhelm Schäfer, Hévila Brognaro, Martin Gand
Publikováno v:
Microorganisms, Vol 9, Iss 8, p 1581 (2021)
Staphylotrichum longicolleum FW57 (DSM105789) is a prolific chitinolytic fungus isolated from wood, with a chitinase activity of 0.11 ± 0.01 U/mg. We selected this strain for genome sequencing and annotation, and compiled its growth characteristics
Externí odkaz:
https://doaj.org/article/9252862f5ce840bbab9e230f94719ab2
Autor:
Mengying Wang, Roland Thuenauer, Robin Schubert, Susanna Gevorgyan, Kristina Lorenzen, Hévila Brognaro, Christian Betzel
Publikováno v:
Soft Matter. 19:1363-1372
Pulsed electric fields (EFs) and a NaCl gradient induce the formation of ordered mesoscopic Alpha-Synuclein (ASN) assemblies with red-shifted emission wavelengths and thermostability.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3564f5d5808ecacc3dcbe91d0e2d093
https://doi.org/10.1039/d2sm01615j
https://doi.org/10.1039/d2sm01615j