Évolution du statut braf dans le melanome : mythe ou Réalité ?

Autor: Elicia Molines, Aurélie Haffner, Frédéric Fina, Nausicaa Malissen, L’Houcine Ouafik, Jean-Jacques Grob, Nicolas Macagno

Publikováno v: Annales de Pathologie
Annales de Pathologie, A paraître, ⟨10.1016/j.annpat.2021.11.001⟩

International audience; Knowledge of the BRAF mutational status has become essential for melanoma therapeutic management. B-Raf inhibitors are associated with significant overall survival in patients with BRAFV600-mutated metastatic melanoma. Althoug

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72d3548661e720dffb47fb7ded5a163d
https://hal-amu.archives-ouvertes.fr/hal-03545740/file/BRAFMacagno.pdf

Place des nanoparticules pour lutter contre la radio-résistance du cancer du sein : impact de l’hétérogénéité tumorale

Autor: Hullo, Marie

Publikováno v: Cancer. Université Paris-Saclay, 2021. Français. ⟨NNT : 2021UPASL004⟩

The use of high-Z nanoparticles to enhance radiotherapy effects has gained momentum over the last decade. Historically, as nanoparticles increase tumor density, they were thought to improve radiation dose by locally increasing the probability of inte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3515::d7d0fcb7e88bae8f4cd7500b4fac58c5
https://theses.hal.science/tel-03540094/document

Characterization of cellular heterogeneity in Diffuse Low Grade Glioma

Autor: Konnully Augustus, Meera Bessy

Publikováno v: Human health and pathology. Université Montpellier, 2020. English. ⟨NNT : 2020MONTT038⟩

Diffuse Low-Grade Gliomas (DLGG) are WHO grade II glial tumors affecting younger adults. They are characterized as silent, slow growing tumors with fewer mitotic activities. However, they diffuse and invade the healthy brain via blood vessels and ner

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1398::51ab2e08628cf94dc37566621a05edd5
https://tel.archives-ouvertes.fr/tel-03156473

L’instabilité génomique, paramètre limitant l’efficacité des thérapies ciblées en oncologie

Autor: Louise-Marie Chevalier, Frédéric Bigot, Alain Morel, Amandine Billaud, Mario Campone

Publikováno v: Bulletin du Cancer
Bulletin du Cancer, John Libbey Eurotext, 2020, S0007-4551 (20), pp.30373-8. ⟨10.1016/j.bulcan.2020.08.010⟩
Bulletin du Cancer, 2020, S0007-4551 (20), pp.30373-8. ⟨10.1016/j.bulcan.2020.08.010⟩

International audience; Genomic instability is one of the main properties of tumour development, promoting first the acquisition of genetic alterations and thus carcinogenesis. Then, the chronic and anarchic proliferation of cancer cells also support

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1514f2f723d24d4ec33155239f2f2e3
https://www.hal.inserm.fr/inserm-02978363/document

Multi-parametric ultrasonic modeling and in vivo characterization of tumor heterogenity and its influence on therapeutic response

Autor: Griffon, Jérôme

Publikováno v: Médecine humaine et pathologie. Sorbonne Université, 2019. Français. ⟨NNT : 2019SORUS123⟩

Intratumor heterogeneity influencing therapy efficiency, the goal of this thesis is, by the combination of parameters extracted from three ultrasound imaging techniques (contrast enhanced, shear wave elastography and quantitative ultrasound), to char

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::0497aa6d4cad8d4b7b5493d00dd04394
https://tel.archives-ouvertes.fr/tel-02946781/file/GRIFFON_Jerome_2019.PDF