Weak synchronization can alter circadian period length: implications for aging and disease conditions

Autor: Jihwan Myung, Sungho Hong, Christoph Schmal, Hélène Vitet, Mei-Yi Wu

Publikováno v: Frontiers in Neuroscience, Vol 17 (2023)

The synchronization of multiple oscillators serves as the central mechanism for maintaining stable circadian rhythms in physiology and behavior. Aging and disease can disrupt synchronization, leading to changes in the periodicity of circadian activit

Externí odkaz: https://doaj.org/article/c816f6b9619743ea954e1dc73b2563d8

Pridopidine rescues BDNF/TrkB trafficking dynamics and synapse homeostasis in a Huntington disease brain-on-a-chip model

Autor: Sophie Lenoir, Romane A. Lahaye, Hélène Vitet, Chiara Scaramuzzino, Amandine Virlogeux, Laetitia Capellano, Aurélie Genoux, Noga Gershoni-Emek, Michal Geva, Michael R. Hayden, Frédéric Saudou

Publikováno v: Neurobiology of Disease, Vol 173, Iss , Pp 105857- (2022)

Huntington disease (HD) is a neurodegenerative disorder caused by polyglutamine-encoding CAG repeat expansion in the huntingtin (HTT) gene. HTT is involved in the axonal transport of vesicles containing brain-derived neurotrophic factor (BDNF). In HD

Externí odkaz: https://doaj.org/article/fd15b7293989424cb83b9058a66155a8

Huntingtin phosphorylation governs BDNF homeostasis and improves the phenotype of Mecp2 knockout mice

Autor: Yann Ehinger, Julie Bruyère, Nicolas Panayotis, Yah‐Se Abada, Emilie Borloz, Valérie Matagne, Chiara Scaramuzzino, Hélène Vitet, Benoit Delatour, Lydia Saidi, Laurent Villard, Frédéric Saudou, Jean‐Christophe Roux

Publikováno v: EMBO Molecular Medicine, Vol 12, Iss 2, Pp 1-13 (2020)

Abstract Mutations in the X‐linked MECP2 gene are responsible for Rett syndrome (RTT), a severe neurological disorder for which there is no treatment. Several studies have linked the loss of MeCP2 function to alterations of brain‐derived neurotro

Externí odkaz: https://doaj.org/article/094d5708255640e8bd9f8ac0e89b5fea

Huntingtin-KIF1A-mediated axonal transport of synaptic vesicle precursors influences synaptic transmission and motor skill learning in mice

Autor: Hélène Vitet, Julie Bruyère, Hao Xu, Jacques Brocard, Yah Sé Abada, Benoît Delatour, Chiara Scaramuzzino, Laurent Venance, Frédéric Saudou

Neurotransmitters are released at synapses by synaptic vesicles (SVs), which originate from SV precursors (SVPs) that have traveled along the axon. Because each synapse maintains a pool of SVs, only a small fraction of which are released, it is uncle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a5843e263f544918886b0bc9be20d552
https://doi.org/10.1101/2022.08.14.503885

Mutations in the KIF21B kinesin gene cause neurodevelopmental disorders through imbalanced canonical motor activity

Autor: Petra J. G. Zwijnenburg, Kirsty McWalter, Sonal Mahida, Delphine Héron, Frédéric Saudou, Hélène Vitet, Anna Chassevent, José Rivera Alvarez, Carlos A. Bacino, Juliette D. Godin, Christel Thauvin-Robinet, Chantal Weber, Laure Asselin, Caroline Nava, Christelle Golzio, Neil A. Hanchard, Christel Depienne, Peggy Tilly, Camille S. Bonnet, Cyril Mignot, Gladys Zapata, Amy Dameron, Marjan M. Weiss, Solveig Heide, Laurence Faivre, Haley Streff, Agnès Rastetter, Kristin W. Barañano

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2020, 11 (1), ⟨10.1038/s41467-020-16294-6⟩
Nature Communications, 11, 1, pp. 1-18
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Nature Communications, 11, 1-18
Asselin, L, Rivera Alvarez, J, Heide, S, Bonnet, C S, Tilly, P, Vitet, H, Weber, C, Bacino, C A, Baranaño, K, Chassevent, A, Dameron, A, Faivre, L, Hanchard, N A, Mahida, S, McWalter, K, Mignot, C, Nava, C, Rastetter, A, Streff, H, Thauvin-Robinet, C, Weiss, M M, Zapata, G, Zwijnenburg, P J G, Saudou, F, Depienne, C, Golzio, C, Héron, D & Godin, J D 2020, ' Mutations in the KIF21B kinesin gene cause neurodevelopmental disorders through imbalanced canonical motor activity ', Nature Communications, vol. 11, no. 1, 2441 . https://doi.org/10.1038/s41467-020-16294-6

KIF21B is a kinesin protein that promotes intracellular transport and controls microtubule dynamics. We report three missense variants and one duplication in KIF21B in individuals with neurodevelopmental disorders associated with brain malformations,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2280cfa8349226d6a47d71980798ba85
https://hal.archives-ouvertes.fr/hal-03373809