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pro vyhledávání: '"Hélène Sabatel"'
Autor:
Hélène Sabatel, Emmanuel Di Valentin, Geoffrey Gloire, Franck Dequiedt, Jacques Piette, Yvette Habraken
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38246 (2012)
The NF-κB pathway is involved in immune and inflammation responses, proliferation, differentiation and cell death or survival. It is activated by many external stimuli including genotoxic stress. DNA double-strand breaks activate NF-κB in an ATM-de
Externí odkaz:
https://doaj.org/article/13e55863d55641a7ba0610a1fc72d908
Publikováno v:
Biochemical Pharmacology. 82:1371-1383
Alteration of the genome integrity leads to the activation of a vast network of cellular responses named "DNA damage response". Three kinases from the phosphoinositide 3-kinase-like protein kinase family regulate this network; ATM and DNA-PK both act