Mechanisms involved in dual vasopressin/apelin neuron dysfunction during aging.

Autor: Julie Sauvant, Jean-Christophe Delpech, Karine Palin, Nadia De Mota, Jennifer Dudit, Agnès Aubert, Hélène Orcel, Pascale Roux, Sophie Layé, Françoise Moos, Catherine Llorens-Cortes, Agnès Nadjar

Publikováno v: PLoS ONE, Vol 9, Iss 2, p e87421 (2014)

Normal aging is associated with vasopressin neuron adaptation, but little is known about its effects on the release of apelin, an aquaretic peptide colocalized with vasopressin. We found that plasma vasopressin concentrations were higher and plasma a

Externí odkaz: https://doaj.org/article/9d061029a0304ac48f86863adfd67f4b

Structures of the arginine-vasopressin and oxytocin receptor signaling complexes

Autor: Julien Bous, Aurélien Fouillen, Hélène Orcel, Sébastien Granier, Patrick Bron, Bernard Mouillac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7e071b7d93e293ff7ed949842851f4f6
https://doi.org/10.1016/bs.vh.2022.12.003

Cryo–electron microscopy structure of the antidiuretic hormone arginine-vasopressin V2 receptor signaling complex

Autor: Patrick Bron, Stefano Trapani, Hélène Orcel, Julien Bous, Nicolas Floquet, Remy Sounier, Cedric Leyrat, Aurelie Ancelin, Julie Saint-Paul, Sébastien Granier, Gérald Gaibelet, Joséphine Lai-Kee-Him, Hélène Déméné, Bernard Mouillac, Maxime Louet

Publikováno v: Science Advances
Science Advances, American Association for the Advancement of Science (AAAS), 2021, 7 (21), pp.eabg5628. ⟨10.1126/sciadv.abg5628⟩
Science Advances, 2021, 7 (21), pp.eabg5628. ⟨10.1126/sciadv.abg5628⟩

Structures of the AVP-V2R-Gs protein complex provide molecular insights into the function of this clinically relevant target.
The antidiuretic hormone arginine-vasopressin (AVP) forms a signaling complex with the V2 receptor (V2R) and the Gs pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b65f240da986a76f1a1199dea9dddac8
http://europepmc.org/articles/PMC8139594

Design, synthesis and biological studies of a library of NK1-Receptor Ligands Based on a 5-arylthiosubstituted 2-amino-4,6-diaryl-3-cyano-4 H -pyran core: Switch from antagonist to agonist effect by chemical modification

Autor: Empar Vengut-Climent, Eleuterio Álvarez, Rocío Recio, Noureddine Khiar, Miguel López-Lázaro, José Manuel Calderón-Montaño, Hélène Orcel, Bernard Mouillac, Inmaculada Fernández

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2017, 138, pp.644-660. ⟨10.1016/j.ejmech.2017.06.056⟩

A library of 5-arylthiosubstituted 2-amino-4,6-diaryl-3-cyano-4H-pyrans has been synthesized as a new family of non-peptide NK1 receptor ligands by a one-pot cascade process. Their biological effects via interaction with the NK1 receptor were experim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4510d7c986f32e8a87c29f91efb9f591
https://doi.org/10.1016/j.ejmech.2017.06.056

Green mamba peptide targets type-2 vasopressin receptor against polycystic kidney disease

Autor: Sabrina Sigismeau, Loïc Quinton, Hélène Orcel, Jérôme Nevoux, Nicolas Gilles, Steve Peigneur, Ralph Witzgall, Justyna Ciolek, Laura Droctové, Enrico A. Stura, Gilles Mourier, Fabrice Beau, Edwin De Pauw, Marc Lombès, Laura Vera, Denis Servent, Helen Reinfrank, Jan Tytgat, Bernard Mouillac, Christiane Mendre, Say Viengchareun

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2017, 114 (27), pp.7154-7159. ⟨10.1073/pnas.1620454114⟩
Proceedings of the National Academy of Sciences of the United States of America, 2017, 114 (27), pp.7154-7159. ⟨10.1073/pnas.1620454114⟩

International audience; Polycystic kidney diseases (PKDs) are genetic disorders that can cause renal failure and death in children and adults. Lowering cAMP in cystic tissues through the inhibition of the type-2 vasopressin receptor (V2R) constitutes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96c2bc7082628374c5642168569897e5
https://hal.umontpellier.fr/hal-02050051