Zobrazeno 1 - 10
of 131
pro vyhledávání: '"Hélène Munier‐Lehmann"'
Autor:
Marielle Cochet, François Piumi, Kamila Gorna, Noémie Berry, Gaëlle Gonzalez, Anne Danckaert, Nathalie Aulner, Odile Blanchet, Stéphan Zientara, Francesc Xavier Donadeu, Hélène Munier-Lehmann, Jennifer Richardson, Alexandra Benchoua, Muriel Coulpier
Publikováno v:
Veterinary Research, Vol 55, Iss 1, Pp 1-13 (2024)
Abstract Outbreaks of West Nile virus (WNV) occur periodically, affecting both human and equine populations. There are no vaccines for humans, and those commercialised for horses do not have sufficient coverage. Specific antiviral treatments do not e
Externí odkaz:
https://doaj.org/article/9abdc7c7e2dd41c3a67553e709f9713f
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
De novo purine nucleotide biosynthesis (DNPNB) consists of sequential reactions that are majorly conserved in living organisms. Several regulation events take place to maintain physiological concentrations of adenylate and guanylate nucleotides in ce
Externí odkaz:
https://doaj.org/article/a46d36049572414686c3f9c4b69993a4
Autor:
Mila Collados Rodríguez, Patrick Maillard, Alexandra Journeaux, Anastassia V. Komarova, Valérie Najburg, Raul-Yusef Sanchez David, Olivier Helynck, Mingzhe Guo, Jin Zhong, Sylvain Baize, Frédéric Tangy, Yves Jacob, Hélène Munier-Lehmann, Eliane F. Meurs
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 19, p 14791 (2023)
Infection with Ebola virus (EBOV) is responsible for hemorrhagic fever in humans with a high mortality rate. Combined efforts of prevention and therapeutic intervention are required to tackle highly variable RNA viruses, whose infections often lead t
Externí odkaz:
https://doaj.org/article/bd6f5c67d6b14e3384fb2d576e3412ba
Autor:
Zhicheng Zhou, Isabelle Staropoli, Anne Brelot, Peggy Suzanne, Aurélien Lesnard, Fanny Fontaine, Serge Perato, Sylvain Rault, Olivier Helynck, Fernando Arenzana-Seisdedos, Jana Sopkova-de Oliveira Santos, Bernard Lagane, Hélène Munier-Lehmann, Philippe Colin
Publikováno v:
Molecules, Vol 28, Iss 3, p 1156 (2023)
The chemokine receptor CXCR4 and its ligand CXCL12 regulate leukocyte trafficking, homeostasis and functions and are potential therapeutic targets in many diseases such as HIV-1 infection and cancers. Here, we identified new CXCR4 ligands in the CERM
Externí odkaz:
https://doaj.org/article/2649592c172747d6a3a95d1a2c3b0285
Autor:
Yanlin Jian, Martijn D. P. Risseeuw, Mathy Froeyen, Lijun Song, Davie Cappoen, Paul Cos, Hélène Munier-Lehmann, Serge van Calenbergh
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 1730-1739 (2019)
A series of readily accessible 1-(piperidin-3-yl)thymine amides was designed, synthesised and evaluated as Mycobacterium tuberculosis TMPK (MtbTMPK) inhibitors. In line with the modelling results, most inhibitors showed reasonable MtbTMPK inhibitory
Externí odkaz:
https://doaj.org/article/60a10e54b7c64ecbbe4411d5e94387b7
Autor:
Côme Thieulent, Christine Fortier, Hélène Munier-Lehmann, Peggy Suzanne, Patrick Dallemagne, Stephan Zientara, Aymeric Hans, Romain Paillot, Pierre-Olivier Vidalain, Stéphane Pronost, Erika Hue
Publikováno v:
Data in Brief, Vol 33, Iss , Pp 106492- (2020)
Data presented in this article are associated with the research article “Identification of antiviral compounds against equid herpesvirus-1 using real-time cell assay screening: efficacy of decitabine and valganciclovir alone and in combination” [
Externí odkaz:
https://doaj.org/article/60a50bb33a2b461e806a7ba47b7e4872
Autor:
Samira Khiar, Marianne Lucas-Hourani, Sébastien Nisole, Nikaïa Smith, Olivier Helynck, Maryline Bourgine, Claude Ruffié, Jean-Philippe Herbeuval, Hélène Munier-Lehmann, Frédéric Tangy, Pierre-Olivier Vidalain
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract The type I interferon response plays a pivotal role in host defense against infectious agents and tumors, and promising therapeutic approaches rely on small molecules designed to boost this system. To identify such compounds, we developed a
Externí odkaz:
https://doaj.org/article/ce16c14d2bc5493eb793e1d6481ee255
Autor:
Yanlin Jian, Fabian Hulpia, Martijn D. P. Risseeuw, He Eun Forbes, Guy Caljon, Hélène Munier-Lehmann, Helena I. M. Boshoff, Serge Van Calenbergh
Publikováno v:
Molecules, Vol 25, Iss 12, p 2805 (2020)
A series of Mycobacterium tuberculosis TMPK (MtbTMPK) inhibitors based on a reported compound 3 were synthesized and evaluated for their capacity to inhibit MtbTMPK catalytic activity and the growth of a virulent M. tuberculosis strain (H37Rv). Modif
Externí odkaz:
https://doaj.org/article/9335a1cb31644688b92dd36518d8dfcd
Autor:
Emna Harigua-Souiai, Yosser Zina Abdelkrim, Imen Bassoumi-Jamoussi, Ons Zakraoui, Guillaume Bouvier, Khadija Essafi-Benkhadir, Josette Banroques, Nathan Desdouits, Hélène Munier-Lehmann, Mourad Barhoumi, N Kyle Tanner, Michael Nilges, Arnaud Blondel, Ikram Guizani
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 12, Iss 1, p e0006160 (2018)
Leishmaniases are neglected parasitic diseases in spite of the major burden they inflict on public health. The identification of novel drugs and targets constitutes a research priority. For that purpose we used Leishmania infantum initiation factor 4
Externí odkaz:
https://doaj.org/article/ebb7e2223ed14d3b805b46d2c9ede416
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0116578 (2015)
Inosine-5'-monophosphate dehydrogenase (IMPDH) occupies a key position in purine nucleotide metabolism. In this study, we have performed the biochemical and physico-chemical characterization of eight bacterial IMPDHs, among which six were totally une
Externí odkaz:
https://doaj.org/article/ddedc7edd1764ce38368b5f35be412ed