Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Hélène Jamann"'
Autor:
Guillaume Bernas, Mariette Ouellet, Andréa Barrios, Hélène Jamann, Catherine Larochelle, Émile Lévy, Jean-François Schmouth
Publikováno v:
BMC Biotechnology, Vol 22, Iss 1, Pp 1-15 (2022)
Abstract Background The discovery of the CRISPR-Cas9 system and its applicability in mammalian embryos has revolutionized the way we generate genetically engineered animal models. To date, models harbouring conditional alleles (i.e. two loxP sites fl
Externí odkaz:
https://doaj.org/article/ac19d34ed8874d3aa11f47807de5d8c1
Autor:
Hélène Jamann, Qiao-Ling Cui, Haritha L. Desu, Florian Pernin, Olivier Tastet, Alexandre Halaweh, Negar Farzam-kia, Victoria Hannah Mamane, Oumarou Ouédraogo, Aurélie Cleret-Buhot, Audrey Daigneault, Renaud Balthazard, Wendy Klement, Florent Lemaître, Nathalie Arbour, Jack Antel, Jo Anne Stratton, Catherine Larochelle
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Multiple sclerosis (MS) is characterized by the loss of myelin and of myelin-producing oligodendrocytes (OLs) in the central nervous system (CNS). Pro-inflammatory CD4+ Th17 cells are considered pathogenic in MS and are harmful to OLs. We investigate
Externí odkaz:
https://doaj.org/article/53dccdeea5ea49b3b922cab52828fef2
Autor:
Florian Pernin, Julia Xiao Xuan Luo, Qiao-Ling Cui, Manon Blain, Milton G F Fernandes, Moein Yaqubi, Myriam Srour, Jeff Hall, Roy Dudley, Hélène Jamann, Catherine Larochelle, Stephanie E J Zandee, Alexandre Prat, Jo Anne Stratton, Timothy E Kennedy, Jack P Antel
Publikováno v:
Brain. 145:4320-4333
Early multiple sclerosis lesions feature relative preservation of oligodendrocyte cell bodies with dying back retraction of their myelinating processes. Cell loss occurs with disease progression. Putative injury mediators include metabolic stress (lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b68efe4622cda3d18f2ef5d03aca2260
https://doi.org/10.1093/brain/awac075
https://doi.org/10.1093/brain/awac075
Autor:
Negar Farzam‐kia, Florent Lemaître, Ana Carmena Moratalla, Yves Carpentier Solorio, Sandra Da Cal, Hélène Jamann, Wendy Klement, Jack Antel, Pierre Duquette, Jean Marc Girard, Alexandre Prat, Catherine Larochelle, Nathalie Arbour
Publikováno v:
Immunology and cell biologyREFERENCES. 101(1)
Granulocyte-macrophage colony-stimulating factor (GM-CSF) has been implicated in numerous chronic inflammatory diseases, including multiple sclerosis (MS). GM-CSF impacts multiple properties and functions of myeloid cells via species-specific mechani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bd6416690291e340035a7828de33fe8
https://pubmed.ncbi.nlm.nih.gov/36260372
https://pubmed.ncbi.nlm.nih.gov/36260372
Autor:
Oumarou Ouédraogo, Renaud Balthazard, Victoria Hannah Mamane, Hélène Jamann, Florence Millette, Audrey Daigneault, Nathalie Arbour, Catherine Larochelle
Publikováno v:
Epilepsy Research. 192:107125
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf4a715d104ffd839e438c94fabde450
https://doi.org/10.1016/j.eplepsyres.2023.107125
https://doi.org/10.1016/j.eplepsyres.2023.107125
Autor:
Guillaume Bernas, Mariette Ouellet, Andréa Barrios, Hélène Jamann, Catherine Larochelle, Émile Lévy, Jean-François Schmouth
BackgroundThe discovery of the CRISPR-Cas9 system and its applicability in mammalian embryos has revolutionized the way we generate genetically engineered animal models. To date, models harbouring conditional alleles (i.e.: two loxP sites flanking an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1c5a99af90f86b5db0c93584a783a59
https://doi.org/10.1101/2021.12.14.471503
https://doi.org/10.1101/2021.12.14.471503
Autor:
Julia Xiao Xuan Luo, Qiao‐Ling Cui, Moein Yaqubi, Jeffery A. Hall, Roy Dudley, Myriam Srour, Nassima Addour, Hélène Jamann, Catherine Larochelle, Manon Blain, Luke M. Healy, Jo Anne Stratton, Joshua A. Sonnen, Timothy E. Kennedy, Jack P. Antel
Publikováno v:
Annals of neurologyReferences. 91(2)
Myelin regeneration in the human central nervous system relies on progenitor cells within the tissue parenchyma, with possible contribution from previously myelinating oligodendrocytes (OLs). In multiple sclerosis, a demyelinating disorder, variables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f56ac1a9660492c91afa82ec39c47cdb
https://pubmed.ncbi.nlm.nih.gov/34952986
https://pubmed.ncbi.nlm.nih.gov/34952986
Autor:
Stefan Bittner, Hélène Jamann, Qiao-Ling Cui, Julian T. Löffel, Frauke Zipp, Miriam Schillner, Beatrice Wasser, Jack P. Antel, Jérôme Birkenstock, Olivier Tastet, Catherine Larochelle, Dirk Luchtman, Albrecht Stroh
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Multiple sclerosis (MS) is a neuroinflammatory, demyelinating disease that represents one of the most frequent causes of irreversible disability in young adults. Treatment options to halt disability are limited. We discovered that T help
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ff7e9a3bb63d8a961f53d917134f334
https://pubmed.ncbi.nlm.nih.gov/34417310
https://pubmed.ncbi.nlm.nih.gov/34417310
Autor:
Guillaume Beaudoin-Bussières, Alexandre Prat, Antoine P. Fournier, Boaz Lahav, Renaud Balthazard, Daniel Kaufmann, Florent Lemaître, Abdelali Filali-Mouhim, Jonathan Richard, Lyne Bourbonnière, Yves Carpentier Solorio, Marc Charabati, Mehdi Benlarbi, Camille Grasmuck, Sai Priya Anand, Hélène Jamann, Nathalie Arbour, Michaël Chassé, Jade Descôteaux-Dinelle, Jérémie Prévost, Elizabeth Gowing, Nathalie Brassard, Victoria Hannah Mamane, Romain Gasser, Madeleine Durand, Ana Carmena Moratalla, Andrés Finzi, Annemarie Laumaea, Nicolas Chomont, Rose Marie Rébillard, Guillaume Goyette, Catherine Larochelle, Olivier Tastet, Negar Farzam-Kia, Marianne Boutin, Karine Thai, Jean François Cailhier, Audrey Daigneault
Publikováno v:
J Clin Invest
Dysregulated immune profiles have been described in symptomatic patients infected with SARS-CoV-2. Whether the reported immune alterations are specific to SARS-CoV-2 infection or also triggered by other acute illnesses remains unclear. We performed f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::372800b23fd263366b8516137b525a43
https://doi.org/10.1172/jci145853
https://doi.org/10.1172/jci145853
Autor:
Victoria Hannah Mamane, Samuel Lapalme-Remis, Mark R. Keezer, Arline Bérubé, Rose-Marie Rébillard, Audrey Daigneault, Boaz Lahav, Nathalie Arbour, Frauke Zipp, Hélène Jamann, Timo Uphaus, Stefan Bittner, Oumarou Ouédraogo, Falk Steffen, Patrick Cossette, Marie-Laure Clénet, Dang Khoa Nguyen, Catherine Larochelle
OBJECTIVE: Adult drug-resistant epilepsy (DRE) is associated with significant morbidity. Infiltration of immune cells is observed in DRE epileptic foci; however, the relation between DRE and the peripheral immune cell compartment remains only partial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3edc627626b6bc0f22135116ac30524